Verbal and non-verbal semantic impairment: From fluent primary progressive aphasia to semantic dementia

Senaha, Mirna Lie Hosogi; Caramelli, Paulo; Porto, Cláudia Sellitto; Nitrini, Ricardo

doi:10.1590/s1980-57642008dn10200014

Cited by 12 publications

(12 citation statements)

References 21 publications

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“…Some of these tasks had been described in a previous study. 25 , 26 As expected for the profile of SD clinical syndrome, all the cases presented low performance in visual confrontation naming (Boston Naming Test - BNT), difficulties on the word definition task and oral word comprehension (word-picture matching task), preserved syntactic comprehension, surface dysgraphia and impairment on tests of non-verbal associative knowledge. The diagnosis of SD was confirmed by experienced cognitive neurologists and was based on clinical history, neurological examination, neuropsychological and language evaluation, and neuroimaging data.…”

Section: Methodssupporting

confidence: 56%

Rehabilitation in semantic dementia: Study of the effectiveness of lexical reacquisition in three patients

Senaha

Brucki

2010

Dement. neuropsychol.

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Although language rehabilitation in patients with primary progressive aphasia (PPA) is recommended, rehabilitation studies in this clinical syndrome are scarce. Specifically, in relation to semantic dementia (SD), few studies have shown the possibility of lexical relearning.ObjectiveTo analyze the effectiveness of rehabilitation for lexical reacquisition in SD.MethodsThree SD patients were submitted to training for lexical reacquisition based on principles of errorless learning. Comparisons between naming performance of treated items (pre and post-training) and non-treated items of the Boston Naming Test (BNT) were made.ResultsAll patients improved their performance in naming treated words after intervention. However, decline in performance in naming of non-treated items was observed. Case 1 named zero items at baseline while her performance post-training was 29.4% correct responses without cueing, and 90.7% correct with and without cueing. Case 2 named 6.9% of items correctly at baseline and his performance in post-training was 52.9% without cueing and 87.3%, with and without cueing. Case 3 named zero items at baseline and his performance in post-training was 100% correct responses without cueing. Considering the performance in naming the non-treated items of the BNT, the percentages of correct responses in the first evaluation and in the re-evaluation, respectively were: 16.7% and 8.3% (case 1; 14 month-interval); 26.7% and 11.6% (case 2; 18 month-interval) and 11.6% and 8.3% (case 3; 6 month-interval).ConclusionsThe reacquisition of lost vocabulary may be possible in SD despite progressive semantic deterioration.

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Section: Methodssupporting

confidence: 56%

Rehabilitation in semantic dementia: Study of the effectiveness of lexical reacquisition in three patients

Senaha

Brucki

2010

Dement. neuropsychol.

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“…All of the patients were submitted to the same language and semantic memory evaluation by the same researcher (MLHS) which included: communication functional evaluation, aphasia battery tests (Beta MT-86, 15 Boston Diagnostic Aphasia Exam, 16 Boston Naming Test, 17 HFSP reading and writing protocols 18 ) and tasks of semantic memory battery described in an earlier paper. 19 …”

Section: Methodsmentioning

confidence: 99%

Semantic dementia: Brazilian study of nineteen cases

Senaha

Caramelli

Porto

et al. 2007

Dement. neuropsychol.

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The term semantic dementia was devised by Snowden et al. in 1989 and nowadays, the semantic dementia syndrome is recognized as one of the clinical forms of frontotemporal lobar degeneration (FTLD) and is characterized by a language semantic disturbance associated to non-verbal semantic memory impairment.ObjectivesThe aim of this study was to describe a Brazilian sample of 19 semantic dementia cases, emphasizing the clinical characteristics important for differential diagnosis of this syndrome.MethodsNineteen cases with semantic dementia were evaluated between 1999 and 2007. All patients were submitted to neurological evaluation, neuroimaging exams and cognitive, language and semantic memory evaluation.ResultsAll patients presented fluent spontaneous speech, preservation of syntactic and phonological aspects of the language, word-finding difficulty, semantic paraphasias, word comprehension impairment, low performance in visual confrontation naming tasks, impairment on tests of non-verbal semantic memory and preservation of autobiographical memory and visuospatial skills. Regarding radiological investigations, temporal lobe atrophy and/or hypoperfusion were found in all patients.ConclusionsThe cognitive, linguistic and of neuroimaging data in our case series corroborate other studies showing that semantic dementia constitutes a syndrome with well defined clinical characteristics associated to temporal lobe atrophy.

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“…Recently some research showed that nonverbal tasks are more affected by right temporal damage (Butler et al, 2009;Ikeda et al, 2006;Mion et al, 2010; but see Thompson et al, 2003), verbal tasks by left temporal damage (Hosogi Senaha et al, 2007;Mion et al, 2010;Thompson et al, 2003).…”

Section: Spared Referential Impaired Inferential Processingmentioning

confidence: 99%

The neural substrates of inferential and referential semantic processing

Marconi

Manenti

Catricalà

et al. 2013

Cortex

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Picture namingNaming by definition Matching fMRI a b s t r a c t Introduction: A distinction has been proposed, on theoretical grounds, between referential and inferential semantic abilities. The former account for the relationship of words to the world, the latter for the relationship of words among themselves. The hypothesis of, at least partially, different neurological underpinnings for this distinction has been supported by the presence of double dissociations in neurological patients between tasks that can be considered to tap the cognitive processes involving these two different classes of semantic knowledge, such as, for example, picture naming (referential) and naming to a verbal definition (inferential). Methods:We report here the results of a functional magnetic resonance experiment, contrasting the pattern of brain activity associated with, respectively, "referential" (picture naming, word-to-picture matching) and "inferential" (naming to definition, word-to-word matching) tasks.Results: All tasks activate an extensive set of brain areas involving both hemispheres, corresponding to the "common semantic network". In addition, left hemispheric temporal areas are selectively engaged by the inferential tasks. Conversely, a specific activation of the right fusiform gyrus is associated with the referential tasks.Conclusions: These findings suggest that while inferential tasks, as compared with referential tasks, engage additional processing resources subserved by left hemispheric language areas involved in lexical retrieval, referential tasks (as compared with inferential tasks) recruit right hemispheric areas generally associated with nonverbal conceptual and structural object processing. These findings are compatible with the double dissociations reported in neurological patients. ª

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Verbal and non-verbal semantic impairment: From fluent primary progressive aphasia to semantic dementia

Cited by 12 publications

References 21 publications

Rehabilitation in semantic dementia: Study of the effectiveness of lexical reacquisition in three patients

Rehabilitation in semantic dementia: Study of the effectiveness of lexical reacquisition in three patients

Semantic dementia: Brazilian study of nineteen cases

The neural substrates of inferential and referential semantic processing

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