A densidade do linfonodo metastático como fator prognóstico no carcinoma espinocelular da língua e soalho bucal

Abstract

The presence of metastatic lymph nodes is a relevant prognostic factor in oral cancer.Objective: This paper aims to assess metastatic lymph node density (pN+) in patients with tongue and floor-of-mouth squamous cell carcinoma (SCC) and the association of this parameter with disease-free survival (DFS). Materials and Methods:A group of 182 patients seen between 1985 and 2007 was included, 169 of which were males. Five were on stage I, 35 on stage II, 56 on stage III, and 85 on stage IV. Median values were considered in lymph node density assessment, and the Kaplan-Meier curve was used to evaluate DFS; survival differences within the group were elicited through the log-rank test.Results: An average 3.2 metastatic lymph nodes were excised from the patients in the group. Density ranged from 0.009 to 0.4, with a mean value of 0.09. Five-year DFS rates were of 44% and 28% for the groups with lymph node densities below and above the median respectively (p = 0.006). Twoyear local/regional control was achieved for 71% and 49% for the patients below and above the median density respectively (p = 0.01). In terms of pN staging, local/ regional control was achieved in 70% and 54% of pN1 and pN2 patients respectively, albeit without statistical significance (0.20%). Conclusion:Lymph node density may be used as a prognostic indicator for tongue and floor-ofmouth SCC. Braz J Otorhinolaryngol. 2012;78(3):86-90. ORIGINAL ARTICLE BJORL

Cociente ganglionar como factor pronóstico de recurrencia tumoral en pacientes con carcinoma escamoso de cavidad oral

“…Así pues, un predictor adicional y emergente del resultado de los pacientes con cáncer de cavidad oral es el LNR. Varios estudios retrospectivos han informado que el LNR es predictivo para la supervivencia global 12,[13][14][15][16][17][18][19][20] , la supervivencia específica de la enfermedad [13][14][15][16][17][18] , la SLE 13,18,21 y el control locorregional 16,19,21 . En el presente estudio se observaron diferencias significativas en el análisis de la SLE (p = 0.018) entre los pacientes con LNR < 0.06 y aquellos con LNR ≥ 0.06.…”