Primary Non-Hodgkins lymphoma of the parotid gland

Dispenza, Francesco; Cicero, Giuseppe; Mortellaro, Gianluca; Marchese, Donatella; Kulamarva, Gautham; Dispenza, Carlo

doi:10.1590/s1808-86942011000500017

Cited by 40 publications

(42 citation statements)

References 36 publications

(62 reference statements)

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“…Surgery can identify a mass as a specific subtype or grade of malignant lymphoma16. Patients who have an early stage parotid gland DLBCL have been shown to have a better prognosis10. The final treatment protocol which included surgery and chemotherapy produced a satisfactory result with no recurrence for 19 months.…”

Section: Discussionmentioning

confidence: 99%

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Malignant lymphoma on parotid gland: a clinical case

Lee

Song

2017

J Korean Assoc Oral Maxillofac Surg

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Non-Hodgkin's lymphoma on the parotid gland is a relatively rare occurrence among head and neck tumors. The mass of parotid gland lymphoma cannot be distinguished from other benign masses of the parotid gland; therefore, it is important to consider lymphoma in the differential diagnosis when examining parotid swellings and masses. Parotid gland lymphoma is most likely to be B-cell, non-Hodgkin's lymphoma of one of three types, which include follicular, marginal zone, and diffuse large B-cell, although other histologic patterns have been described. We present a review of a patient with diffuse large B-cell lymphoma (DLBCL) who presented to the Department of Oral and Maxillofacial Surgery of Pusan National University Hospital (Yangsan, Korea).

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Section: Discussionmentioning

confidence: 99%

“…Clinical or radiographic features providing a definitive diagnosis are not distinguishable. Because of these difficulties, surgical procedures are undertaken, such as parotidectomy10.…”

Section: Introductionmentioning

confidence: 99%

Malignant lymphoma on parotid gland: a clinical case

Lee

Song

2017

J Korean Assoc Oral Maxillofac Surg

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“…These may arise from the intraparotid lymph nodes or the gland itself. The parotid gland contains as histological characteristic intraparotid lymph nodes and, in consequence, it is difficult to distinguish between lymphoma arising primarily in the salivary gland and those arising in intraparotid lymph nodes 9,10 . Hyman and Wolff proposed several criteria in order to establish the diagnosis of primary parotid lymphoma: a.…”

Section: Discussionmentioning

confidence: 99%

“…Architectural and cytological confirmation of the malignant nature of the infiltrate. Following these three criteria, our case was diagnosed as a primary parotid lymphoma 9,10 . Patients with primary Sjogren's syndrome showed a 16-44 higher risk to develop lymphomas than the general population, as reported by two large case series studies 11 .…”

Section: Discussionmentioning

confidence: 99%

Case report. A rare case of triple-hit diffuse large B-cell lymphoma of the parotid gland in a patient with Sjogren’s syndrome

Birceanu

Evsei

Dumitru

et al. 2017

Romanian Journal of Rhinology

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A rare case of triple-hit diffuse large B-cell lymphoma of the parotid gland in a patient with Sjogren's syndrome CASE REPORT INTRODUCTIONPrimary lymphoma of the salivary gland is rare, accounting for 2-5% of all salivary neoplasms. Diffuse large B-cell lymphomas (DLBCL) are uncommon, most salivary gland lymphoid malignancies being lowgrade lymphomas with MALT (mucosa associated lymphoid tissue) lymphomas being the most common. The majority of primary salivary gland DLBCLs appear to arise from MALT type lymphomas in a background of sialadenitis associated with autoimmune disorders, such as Sjogren syndrome [1][2][3][4] . The pathophysiology of Non-Hodgkin Lymphoma (NHL) is unknown. However, some risk factors are related to NHL development, such as acquired or druginduced immunodeficiency, some autoimmune diseases or Sjogren's syndrome 5 . Double and triple-hit B-cell lymphoma (DHL, THL) are rare lymphoma subtypes usually associated with poor prognosis. These specific subtypes are defined by two or three recurrent chromosome translocations: MYC/8q24loci, usually in combination with the t(14;18)(q32; q21) bcl-2 gene and/or BCL6 3q27 chromosomal translocation. Here, we present one case with diffuse large B-cell lymphoma associated with follicular lymphoma transformed to THL 6 . ABSTRACT BACKGROUND. Primary malignant lymphomas of the salivary gland are rare, accounting for 2% of salivary gland tumors and 5% of all extranodal lymphomas. The clinical presentation is not particularly characteristic, a feature that usually leads to diagnostic and treatment delays. CASE REPORT.We report a case of a parotid gland triple-hit diffuse large B-cell (DLBCL) lymphoma associated with follicular lymphoma in a 76-year-old female patient with a unique personal history, which included a diagnosis of Sjogren Syndrome and exposure to a toxic working environment with pesticides. Diffuse large B-cell lymphomas are uncommon given the fact that most lymphoid malignancies are low-grade lymphomas, with MALT (mucosa associated lymphoid tissue) lymphomas being the most common. Triple-hit DLBCL are extremely rare and the diagnosis can be challenging. Parotidectomy, as the first step, must be followed by histopathology and immunohistochemistry for final diagnosis and treatment.CONCLUSION. This case highlights the fact that B-cell lymphoma in the salivary gland can be unrecognized due to unspecific symptoms and requires immunohistochemistry studies for confirmation. It is important to recognize triple-hit lymphoma due to its worse prognosis and differentiated treatment. Patients with Sjogren syndrome have additional risk factors for progression to lymphoma.

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“…[1] Lymphomas primarily in the salivary gland tissue are very rare, the incidence being 0.3% of all tumors, 2-5% of all salivary gland tumors, and 5% of extranodal lymphomas. [2] The first case of mucosa-associated lymphoid tissue (MALT) lymphoma was reported in 1963. Clinical presentation is not characteristic and the disease is often overlooked, resulting in late diagnosis and treatment.…”

Section: Introductionmentioning

confidence: 99%

Diffuse large B-cell lymphoma of the parotid gland: Cytological, histopathological, and immunohistochemical features: A rare case report

Andola

Masgal

Reddy

2016

J Cytol

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Primary malignant lymphomas of the salivary glands are rare, accounting for 2-5% of salivary gland tumors and 5% of extranodal lymphomas, frequently seen in the parotid gland. There are single case reports mentioned in the literature. Clinical presentation is not characteristic and the disease is often overlooked with delay in diagnosis and treatment. We are reporting a case of bilateral parotid gland lymphoma in a 55-year-old male, presented with bilateral enlarged parotids. Magnetic resonance imaging (MRI) showed bilateral enlarged parotid glands with multiple well-defined intraparotid lesions. Fine Needle Aspiration Cytology (FNAC) of both showed mixed population of lymphoid cells with large monocytoid cells with scant cytoplasm, anisonucleosis with prominent nucleoli, and numerous mitoses suggestive of non-Hodgkin's lymphoma (NHL). Histopathology showed sheets of large lymphoma cells destructing the salivary acini and infiltrating the periparotid fat. Immunohistochemistry (IHC) showed diffuse CD20 positivity, B-cell lymphoma 6 protein (Bcl-6) was focally positive and negative for cluster of differentiation (CD) 3, CD5, CD10, and Multiple myeloma oncogene-1 (MUM1) which led to the diagnosis of NHL-Diffuse large B cell type.

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Primary Non-Hodgkins lymphoma of the parotid gland

Cited by 40 publications

References 36 publications

Malignant lymphoma on parotid gland: a clinical case

Malignant lymphoma on parotid gland: a clinical case

Case report. A rare case of triple-hit diffuse large B-cell lymphoma of the parotid gland in a patient with Sjogren’s syndrome

Diffuse large B-cell lymphoma of the parotid gland: Cytological, histopathological, and immunohistochemical features: A rare case report

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