Malignant lymphoma on parotid gland: a clinical case

Abstract

Non-Hodgkin's lymphoma on the parotid gland is a relatively rare occurrence among head and neck tumors. The mass of parotid gland lymphoma cannot be distinguished from other benign masses of the parotid gland; therefore, it is important to consider lymphoma in the differential diagnosis when examining parotid swellings and masses. Parotid gland lymphoma is most likely to be B-cell, non-Hodgkin's lymphoma of one of three types, which include follicular, marginal zone, and diffuse large B-cell, although other histologic patterns have been described. We present a review of a patient with diffuse large B-cell lymphoma (DLBCL) who presented to the Department of Oral and Maxillofacial Surgery of Pusan National University Hospital (Yangsan, Korea).

Pediatric follicular lymphoma of the parotid gland

“…As Park et al [10] stated in their case report of parotid lymphoma, the standard surgical procedure for PFL requires en bloc excision of the mass with superficial parotidectomy. This is because direct infiltration into the parotid gland parenchyme is occasionally found in postoperative pathology, although PFL is not a true parotid gland neoplasm [4,11]. Due to the patient’s young age and well-differentiated cellular morphology, local radiotherapy rather than systemic chemotherapy was chosen for adjuvant treatment.…”

Mucosa-associated lymphoid tissue lymphoma of the accessory parotid gland presenting as a simple cheek mass

“…While HL usually arises from the inguinal, axillary, and cervical nodes, NHL occurs at extranodal sites. [4]…”

“…[11] This gland may be either continuous with or separated from the main parotid gland. [11] Among the tumors that may arise in the parotid gland, NHL only accounts for 1% to 4%, [1,4] with subtypes including follicular lymphoma, diffuse large B-cell lymphoma, and MALT lymphoma. [6] Of these subtypes, development of MALT lymphoma in the parotid gland is rare [1,5] ; further, its development in the accessory parotid gland is especially rare, and such cases have scarcely been reported.…”

“…A simple diagnostic method to obtain pathological findings is fine needle aspiration biopsy. [4,5,12] On cytology, MALT lymphoma is positive for CD20 and CD79a, and negative for CD5, CD10, and cyclin D1. [5,6]…”

“…[1–3] It usually occurs in the gastric mucosa, but may also develop in other sites, such as the gastrointestinal tract, lung, breast, ocular adnexa, and salivary glands. [4] However, it is unusual for MALT lymphoma to develop in the parotid gland, [1,4,5] and cases of MALT lymphoma in the accessory parotid gland are especially rare [6] ; thus, such cases are easily confused with other types of soft tissue masses, such as abscesses, sialoceles, epidermal inclusion cysts, and other benign parotid gland tumors. We report a case of a 56-year-old woman with MALT lymphoma that developed in the accessory parotid gland, which could have easily been mistaken for another type of soft tissue mass.…”