Avaliação audiológica em pacientes portadores de hipotireoidismo

Santos, Karlos Thiago Pinheiro dos; Dias, Norimar Hernandes; Mazeto, Gláucia Maria Ferreira da Silva; Carvalho, Lídia Raquel de; Lapate, Renan Luis; Martins, Regina Helena Garcia

doi:10.1590/s1808-86942010000400012

Cited by 28 publications

(2 citation statements)

References 16 publications

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“…About 25% of patients with acquired hypothyroidism and 30-50% of patients with CH identified before the introduction of screening programs and treated late are thought to display hearing loss, which is partially reversed by TH replacement treatment (42,43,44,45,46). Hearing loss has also been reported in cases of endemic cretinism (47), in patients with TH resistance (48), and in patients with TH monocarboxylate transporter 8 (MCT8) abnormalities (49).…”

Section: Neurosensory Developmentmentioning

confidence: 99%

ENDOCRINOLOGY AND ADOLESCENCE: Congenital hypothyroidism: a clinical update of long-term outcome in young adults

Léger

2015

European Journal of Endocrinology

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Congenital hypothyroidism (CH) is the most common congenital endocrine disorder. The early treatment of CH patients has successfully improved the prognosis and management of this disorder. Optimal treatment and management throughout the patient's life, beginning in the neonatal period, are required to ensure long-term health. Affected patients should be offered assessments of associated medical conditions and provided with accurate information about their condition throughout their lives, but particularly during the transition from pediatric to adult services. This review provides a summary of current knowledge about the long-term outcomes of these patients and appropriate management into early adulthood. We carried out a systematic search of the Medline database to identify relevant articles. Despite major improvements in prognosis, the impact of CH is clearly not uniform, and management should take into account a broader range of relevant indicators, including CH severity, associated comorbid conditions and the adequacy of treatment during childhood and adulthood. The early diagnosis and management of associated medical conditions, and better educational strategies to improve compliance with treatment, should improve the long-term prognosis. Further studies are required to explore changes with aging.

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Section: Neurosensory Developmentmentioning

confidence: 99%

ENDOCRINOLOGY AND ADOLESCENCE: Congenital hypothyroidism: a clinical update of long-term outcome in young adults

Léger

2015

European Journal of Endocrinology

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“…Thyroid hormone plays a vital role in the developmental maturation of hair cells spiral and ganglion cells as well as in the metabolism of the vascular cortex and stria vascularis ( 11 – 14 ). Thyroid dysfunction (hypothyroidism and hyperthyroidism) has been associated with increased hearing thresholds, abnormal V wave, and TOAE in auditory brainstem responses ( 15 , 16 ). Additionally, there is evidence that SSNHL patients suffered from a higher prevalence of thyroid disease in comparison to the general population ( 17 ).…”

Section: Introductionmentioning

confidence: 99%

Causal associations of thyroid function and sudden sensorineural hearing loss: a bidirectional and multivariable Mendelian randomization study

Chen,

Wu,

et al. 2023

Front. Neurol.

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BackgroundObservational studies have indicated a potential association between thyroid dysfunction and the risk of sudden sensorineural hearing loss (SSNHL). However, the precise causal relationship between the two remains uncertain. The objective of our study was to assess the causal influence of thyroid function on SSNHL by employing a bidirectional and multivariable Mendelian randomization (MR) approach.MethodsSingle-nucleotide polymorphisms (SNPs) associated with free thyroid (FT4) and thyroid stimulating hormone (TSH) were selected from the summary data of a large genome-wide association study (GWAS) conducted on European individuals. The summary-level data of SSNHL were also obtained from a GWAS, which included 196,592 participants (1,491 cases and 195,101 controls). The MR analysis primarily utilized the inverse variance weighted (IVW) method, with sensitivity analyses performed using the weighted median, MR-Egger, and MR-PRESSO approaches.ResultsIn the IVW method, an elevated genetically predicted FT4 level was found to effectively reduce the risk of SSNHL (OR = 0.747, 95% CI = 0.565–0.987, P = 0.04). These findings were consistent when conducting multivariate MR analysis, which adjusted for TSH levels (OR = 0.929, 95% CI = 0.867–0.995, P = 0.036). However, genetically predicted TSH levels did not emerge as a risk factor for SSNHL (OR = 1.409, 95% CI = 0.895–1.230, P = 0.547). Furthermore, even after adjusting for FT4 levels in the multivariate MR analysis, no evidence of a direct causal relationship between TSH levels and the risk of SSNHL was observed (OR = 1.011, 95% CI = 0.880–1.161, P = 0.867). The reverse MR analysis showed that there was no evidence of a direct causal relationship between SSNHL and the risk of FT4 level (OR = 1.026, 95% CI = 0.999–1.054, P = 0.056) or TSH level (OR = 1.002, 95% CI = 0.989–1.015, P = 0.702).ConclusionWithin the normal range, genetic variants associated with higher FT4 levels demonstrate a potential protective effect against SSNHL, whereas there is no direct causal relationship between TSH levels and the risk of SSNHL.

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Autoimmune thyroiditis in patients with sudden sensorineural hearing loss

Sun

Zhuang

Xiao

et al. 2022

Laryngoscope Investig Oto

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Objective This study aims to evaluate the association between autoimmune thyroiditis and Sudden Sensorineural Hearing Loss (SSNHL). Methods Hundred and five patients with SSNHL were enrolled. Audiometric tests, serum thyroid autoantibodies (TPOAb, TgAb) were studied. Based on the thyroid autoantibody results, patients were divided into two groups: thyroid autoantibody‐positive and negative. The relationship between thyroid autoimmunity and audiological characteristics was analyzed. Results Twenty‐six patients (24.8%) of the SSNHL had thyroid autoantibody elevated. The pure tone average (PTA) of patients with and without thyroid autoantibody is 60 ± 38.51 and 54.99 ± 33.87 dBHL, respectively. The PTA was significantly improved in both groups after treatment (p < 0.001), but the hearing gains were similar in both groups (p = 0.205). Hearing loss of 2000–8000 Hz was worse than 125–1000 Hz among thyroid autoantibody‐positive patients (p < 0.05), but the hearing improvement of both groups have no significant difference. The hearing improvement of 125–1000 Hz is significantly better than 2000–8000 Hz among patients with thyroid autoantibody negative (p < 0.05). Conclusions We speculate that a potential association between thyroid autoimmunity and SSNHL. Thyroid autoimmunity may be a pathogenesis factor of SSNHL and associated with more severe hearing loss of high‐frequency hearing.

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Avaliação audiológica em pacientes portadores de hipotireoidismo

Cited by 28 publications

References 16 publications

ENDOCRINOLOGY AND ADOLESCENCE: Congenital hypothyroidism: a clinical update of long-term outcome in young adults

ENDOCRINOLOGY AND ADOLESCENCE: Congenital hypothyroidism: a clinical update of long-term outcome in young adults

Causal associations of thyroid function and sudden sensorineural hearing loss: a bidirectional and multivariable Mendelian randomization study

Autoimmune thyroiditis in patients with sudden sensorineural hearing loss

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