Avaliação da idade materna, paterna, ordem de paridade e intervalo interpartal para fissura lábio-palatina

Abstract

Cl eft lip and palate (CL/P) are the most common congenital craniofacial anomalies. Aim: To evaluate environmental risk factors for non-syndromic CL/P in a reference care center in Minas Gerais. Materials and Methods: we carried out a case-controlled study, assessing 100 children with clefts and 100 children without clinical alterations. The analysis dimensions (age, skin color, gender, fissure classification, maternal and paternal age, birth order and interpregnancy interval), obtained from a questionnaire; and later we build a data base and the analyses were carried out by the SPSS 17.0 software. The results were analyzed with the relative risk for each variable, in order to estimate the odds ratio with a 95% confidence interval, followed by a bivariate and multivariate analysis. Results: among 200 children, 54% were males and 46% were females. As far as skin color is concerned most were brown, white and black, respectively. Cleft palates were the most common fissures found (54%), followed by lip cleft (30%) and palate cleft (16%). Conclusion: although with a limited sample, we noticed an association between maternal age and an increased risk for cleft lip and palate; however, paternal age, pregnancy order and interpregnancy interval were not significant.

Desempenho cognitivo-linguístico de crianças com fissura labiopalatina em fase de aquisição da leitura e escrita

“…In this present study, the sample characterization with predominance of males in G1, corroborated other studies 18,19 . Epidemiological findings have shown gender differences in incidence, prevalence, during alterations of development and behavior 20 , however, in the population with cleft lip and palate, prospective studies have not been registered to justify this rate, due to the wide range of genetic and teratogenic factors related, although there is a higher prevalence for females, as for post-foramen type, and a prevalence for males, as for pre and trans-foramen types 14 .…”

A discriminant analysis prediction model of non-syndromic cleft lip with or without cleft palate based on risk factors

“…Second, due to the small sample size and the low exposure rates of some of the investigated factors, some common important risk factors were not included in the prediction model, such as maternal age, folic acid intake, history of infection during pregnancy, mothers’ abnormal reproductive history, medication use during pregnancy, maternal stressful events during pregnancy, tobacco, and alcohol. Many of the published papers show conflicting results on the relationship between maternal age and NSCL/P [10, 12, 41]. The effect of folic acid on NSCL/P has generated debate in previous studies [28, 41, 42].…”

“…Recently, most studies have focused on the identification of risk factors of NSCL/P. Many epidemiological studies have confirmed that maternal age [10–12], maternal educational level [2, 13], family income [13, 14], abnormal reproductive histories [15], family history [14–16], history of infection during pregnancy [17], medication use during pregnancy [18, 19], ambient environment pollution [20], parental occupational hazards exposure [21–23], maternal nutrient intake [23–26], and maternal lifestyle factors (alcohol drinking, smoking) [27–29] are associated with NSCL/P. However, an individual risk prediction tool for NSCL/P has not been reported.…”

Nascidos vivos com fissura de lábio e/ou palato: as contribuições da fonoaudiologia para o Sinasc

“…The higher occurrence in males was also found in Brazil 22,23 and in other parts of the world 24,25 . Related to the type of cleft, the findings in this study confirm the predominance of the transforamen cleft, as observed by other researchers 2,15,21,22 . In the Coope et al study (2000) 21 for instance, the occurrence of cleft lip and palate (65%) was approximately twice as high as cleft lip only (35%).…”