Ki-67 and p53 correlation prognostic value in squamous cell carcinomas of the oral cavity and tongue

Motta, Rafael da Ros; Zettler, Cláudio Galleano; Cambruzzi, Eduardo; Jotz, Geraldo Pereira; Berni, Renata Brutti

doi:10.1590/s1808-86942009000400013

Cited by 31 publications

(28 citation statements)

References 21 publications

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“…Moreover, on comparing mean Ki-67 LI in the two groups of lymph node status for each grade of carcinoma, it was found that subjects with positive lymph node metastasis had comparatively higher mean Ki-67 LI than subjects with negative lymph node metastasis (Table 3). These observations were in consonance with the study by Motta et al 23 Thus, it may be implicated that tumors with a high cell PI (such as the mean Ki-67 LI) may indicate a potential for these tumors to metastasize.…”

Section: Discussionsupporting

confidence: 91%

Proliferative Index in Invasive Tumor Front of Oral Squamous Cell Carcinoma: A Potential Prognostic Indicator

Bhuyan¹,

Sarangi²,

Das³

et al. 2018

The Journal of Contemporary Dental Practice

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Aim:The aim of the study was to evaluate the proliferative index (PI) at their invasive front of oral cancer and their association with Bryne's grades of oral squamous cell carcinoma (OSCC) and compare the PI with lymph node metastasis, site of involvement, and habits. Materials and methods:The Ki-67 antigen expression was immunohistochemically evaluated in a total of 102 cases that included the histopathologically diagnosed archival specimens of OSCCs. They were subdivided by Bryne's histopathological grading into grade I (40 cases), grade II (32 cases), and grade III (30 cases). The nucleus with brown stain was considered positive. Cells were counted under 400× magnification. The proliferative activity thus determined was then expressed as a percentage of Ki-67 labeling index (Ki-67 LI) positive cells. Results:A stepwise increase in the mean Ki-67 LI was found from grade I to III squamous cell carcinoma, thus correlating with the histological grading. In addition, there was a higher PI seen in cases associated with metastatic lymph node, which concords with the higher biologic aggressiveness and poor prognosis of the lesion. Conclusion:The present study shows a definitive correlation of Ki-67 antigen with the Bryne's histological grading, all the parameters of Bryne's grading for OSCC and lymph node status of the patient proving its association as an effective tool to grade the tumors and finally read the prognosis of the tumor. Clinical significance: Cell proliferation is regarded as one of the most important biologic mechanisms in oncogenesis. The role of cell proliferation in tumor progression has been inferred in studies concerned with human cancer by comparing the PI of normal tissue, preneoplastic and neoplastic lesions. The Ki-67 antigen-labeled cells can prove to be an effective aid to grade the tumors. It might be possible to standardize and objectify tumor grading among pathology laboratories. Proliferative Index in Invasive Tumor

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Section: Discussionsupporting

confidence: 91%

Proliferative Index in Invasive Tumor Front of Oral Squamous Cell Carcinoma: A Potential Prognostic Indicator

Bhuyan¹,

Sarangi²,

Das³

et al. 2018

The Journal of Contemporary Dental Practice

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“…It means that p53 expressions in those squamous cell carcinoma cases of oral cavity were correlated with a poor prognosis (grade III). This finding is in accordance with an opinion of Motta et al 10 stating that there is a correlation between p53 and a poor prognosis in oral cavity squamous cell carcinoma. p53 expressions in grading I indicates a highly significant correlation (p<0.01) due to the low expression distribution (4 cases) and the weak intensity (4 cases) on histopathological grading I.…”

Section: Discussionsupporting

confidence: 93%

“…This finding is consistent with a research conducted by Rodrigues et al showing that there is no correlation between immunohistochemical p53 and histopathological grading in predicting prognosis for 30 cases of squamous cell carcinoma of larynx. 13 Similarly, another research conducted by Motta et al 10 also shows that there is no significant correlation between p53 and histopathological grading in predicting prognosis for 28 cases of squamous cell carcinoma of oral cavity.…”

Section: Discussionmentioning

confidence: 93%

“…2 Unlike the previous researches, the researches show that there is no significant correlation between p53 expressions and histopathological grading I, II and III. 10,[13][14][15] For those reasons, this study aimed to determine the role of p53 in immunohistochemistry as well as the correlation between p53 expressions and histopathological grading in oral cavity squamous cell carcinoma. In all 20 cases of squamous cell carcinoma classified by grading I, II and III, there was no correlation between p53 expressions and histopathological grading in those three groups as a whole.…”

Section: Discussionmentioning

confidence: 99%

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Corellation of p53 expressions and histopathological grading in oral cavity squamous cell carcinoma

Kintawati

2016

Dent. J. (Majalah Kedokteran Gigi)

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“…therefore, the presence of Ki-67 is considered to be a 'proliferation index' of tumors (39). In oral cancers, patients with tumors with high positivity (92%) or lymph node metastasis had a poor outcome (40), and many studies indicated that Ki-67 could be an important prognostic factor (41)(42)(43)(44). similarly, 92% of subjects showed Ki-67 expression in our study.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological significance of carbonic anhydrase 9, glucose transporter-1, Ki-67 and p53 expression in oral squamous cell carcinoma

Kondo

Yoshikawa

Omura³

et al. 2011

Oncol Rep

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Abstract. carbonic anhydrase 9 (cA9) is a glycoprotein present on the surface of cell membranes. It is expressed in 90% of renal cancer cells, but not in normal kidney tissue. Immunotherapy targeting cA9 is underway, and our group has also conducted a clinical trial using cA9 as a cancer vaccine and confirmed the induction of cytotoxic T lymphocytes, with efficacy in some cases. Expression of CA9 antigen in oral cancer has not been reported in Japan, but our results indicate that immunotherapy targeting cA9 might be possible. We immunohistochemically observed the expression of antigens such as cA9, Ki-67, glucose transporter-1 (glUt-1) and p53 in 107 subjects with oral squamous cell carcinoma, and examined their correlation with clinicopathological parameters. Immunostaining analysis showed expression of cA9 in 98% of oral cancer subjects, and the survival rate was significantly lower in subjects with CA9 antigen expression in 50% or more cells (p<0.05). subjects with poorly differentiated, t4 and lymph node metastasis, or stage IV cancer with high CA9 expression (≥50%) had a worse outcome than those with low cA9 expression. Although glUt-1 expression was observed in 98% of subjects, similarly to cA9 expression, no significant correlation between its expression and the survival rate was seen. However, subjects with lymph node metastasis had significantly higher GLUT-1 expression, demonstrating that glUt-1 could be an indicator of lymph node metastasis. Ki-67 was expressed in 92% of subjects, but no correlation with outcome was observed. expression of p53 was noted in 78% of subjects, and it was found that many oral cancers have p53 genetic abnormalities, but no correlation between p53 and outcome was observed. It was confirmed that CA9 antigen is expressed in most oral cancer subjects, suggesting the possibility of immunotherapy targeting cA9 antigen in oral cancer.

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Ki-67 and p53 correlation prognostic value in squamous cell carcinomas of the oral cavity and tongue

Cited by 31 publications

References 21 publications

Proliferative Index in Invasive Tumor Front of Oral Squamous Cell Carcinoma: A Potential Prognostic Indicator

Proliferative Index in Invasive Tumor Front of Oral Squamous Cell Carcinoma: A Potential Prognostic Indicator

Corellation of p53 expressions and histopathological grading in oral cavity squamous cell carcinoma

Clinicopathological significance of carbonic anhydrase 9, glucose transporter-1, Ki-67 and p53 expression in oral squamous cell carcinoma

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