Correlation between histocompatibility antigens and recurrent aphthous stomatitis in the brazilian population

Wilhelmsen, Niels Salles Willo; Weber, Raimar; Monteiro, Francisco; Kalil, Jorge; Miziara, Ivan Dieb

doi:10.1590/s1808-86942009000300019

Cited by 14 publications

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“…(15,18) However, the prevalence of RAS (19.33%) in psychiatric patients was comparable to that in the normal population (17,19). To explain the association between the high prevalence of BMS and OLP and psychological factors, evidence from previous studies can be considered.…”

Section: Discussionmentioning

confidence: 97%

Prevalence of oral mucosal disorders in institutionalized and non-institutionalized psychiatric patients: a study from AVBR Hospital in central India

et al. 2012

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Dental treatment is reported to be the greatest unattended health need of people with a disability. The aim of the present study was therefore to quantify the prevalence of oral diseases with a psychosomatic component (recurrent aphthous stomatitis, burning mouth syndrome, and oral lichen planus) in psychiatric patients and to screen these patients for any other oral disorders, so that better care could be provided. In this cross-sectional, singleassessment study, 150 psychiatric patients were evaluated for presence of oral disorders. They were screened based on their socio-demographic profiles, clinical profile, and standardized psychiatric scales. The prevalence of recurrent aphthous stomatitis (RAS), burning mouth syndrome (BMS), and oral lichen planus (OLP) was 19.33% (29 patients), 20.66% (31 patients) and 5.33% (8 patients), respectively, amongst all psychiatric patients. The prevalence of burning mouth syndrome was much higher in patients taking psychiatric medications (25%) than in drug-naïve patients. On screening for other oral disorders, 35.33% of psychiatric patients had at least one other such disorder. We concluded that this patient group experiences a considerable burden of occult oral disorders necessitating thorough oral care. We also described the possible causes of the higher prevalence of oral disorders in psychiatric patients. (J Oral Sci 54, 85-91, 2012)

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Section: Discussionmentioning

confidence: 97%

Prevalence of oral mucosal disorders in institutionalized and non-institutionalized psychiatric patients: a study from AVBR Hospital in central India

et al. 2012

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“…Pekiner et al [25] found that the HLA-A24 frequency was significantly higher in the RAOU patient group than in healthy subjects. In Brazilians, RAOU was associated with HLA-A33, HLA-B35, and HLA-B81 [26] . In Caucasians, patients with RAOU showed a higher frequency of HLA-B12 [27] , HLA-DR7, and HLA-DR5 [28] , and lower incidence of HLA-B5 and HLA-DR4 [28] when compared with HCs.…”

Section: Discussionmentioning

confidence: 93%

“…Nevertheless, studies on HLA associations with BD considered HLA-B51 antigen as the strongest evidence of a BD genetic background. Indeed, some reports also implicated the probable role of HLA antigen inheritance in the RAOU immunopathogenesis [4][5] .…”

Section: Introductionmentioning

confidence: 99%

Beyond Human Leukocyte Antigen Class I Antigens: Hereditary Hemochromatosis Gene Mutations in Recurrent Aphthous Oral Ulcers and Behçet Disease in the South of Tunisia

Elaoud

Kamoun²,

Mahfoudh³

et al. 2017

Med Princ Pract

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Objective: The aim of this work was to establish human leukocyte antigen (HLA) class I and hereditary hemochromatosis gene (HFE) mutation associations with recurrent aphthous oral ulcers (RAOU) and Behçet disease (BD) in a cohort of Southern Tunisian patients. Subjects and Methods: A total of 232 patients with RAOU and 123 healthy controls (HCs) were enrolled in this study. The patients were divided into 2 groups based on the presence (BD+: n = 62) or absence of BD (BD−, n = 170). In the BD+ group, 28 patients had severe manifestations of BD. In the BD- group, RAOU was isolated in 81 patients, associated with mucocutaneous manifestations in 58 and with joint symptoms in 25. Complement-dependent microlymphocytotoxicity assay and polymerase chain reaction-restriction fragment length polymorphism were used to study HLA class I polymorphism and HFE mutations, respectively. Results: HLA-B51 was positively associated with BD, particularly in those with severe manifestations. No association was detected with HLA class I polymorphism among the BD group. Based on stratification to clinical manifestations, the isolated RAOU was negatively associated with HLA-A1 with a difference close to significance (12 [14.81%] vs. 32 [26.02%] in HCs; p = 0.06). Furthermore, patients with mucocutaneous features had a higher frequency of HLA-B51 (14, 24.14%) than patients without mucocutaneous involvement (11, 11.37%). Considering HFE mutations, patients with isolated RAOU had a higher frequency of H63D when compared with other subgroups, especially after limiting the comparison to 27 patients of at least 5 years of follow-up. Conclusion: This study showed that, unlike BD, RAOU were not associated with HLA-B51. Moreover, we suggest that H63D mutation was positively associated with isolated RAOU.

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“…for RAS development [35]. Allergy or food intolerance is often associated with atopy; a significant association with a history of atopy has been seen in patients with a family history of RAS [36]. The association between RAS and psychological factors including stress and anxiety has been suggested in a growing number of studies [2,37].…”

Section: Discussionmentioning

confidence: 99%

VEGF, sVEGFR-1 and Endostatin Serum Levels and VEGF Polymorphisms in Recurrent Aphthous Stomatitis

Yüce¹

2016

Ann Clin Anal Med

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Rekürren aftöz stomatit (RAS) oral mukozanın en sık görülen hastalıklarından biridir ve kronik, ağrılı, tekrarlayan ve nekrotizan ülserasyonlarla karakterizedir. RAS'ın kesin etiyolojisi ve patogenezi açıklanamamıştır. Bu yüzden, Türk RAS'lı hastalarda serum VEGF, sVEGFR-1 ve endostatin düzeylerini; ve ayıca VEGF +936 C/T ve-1154 G/A tek nükleotid polimorfizmlerinin (SNP'ler) frekanslarını araştırmayı amaçladık. Gereç ve Yöntem: 42 RAS'lı hasta (24 minör RAS ve 18 majör RAS) ve 37 sağlıklı birey çalışmaya dahil edildi. Serum VEGF, sVEGFR-1 ve endostatin düzeyleri ELİZA yöntemiyle ölçüldü. VEGF +936 C/T ve-1154 G/A SNP'leri PCR-RFLP metoduyla tanımlandı. Bulgular: VEGF serum düzeyi ortalaması +936 C/T SNP'sinin CC genotipini taşıyanlarda CT genotipini taşıyanlara göre daha yüksek bulundu (639.5 ± 309.1 vs 442.1 ± 197.8; p = 0.032). VEGF-1154 GA ve GG genotipleri sırasıyla minor RAS ve major RAS'lı hastalarda daha sık olarak bulundu (p = 0.022). Minor RAS ile major arasında serum VEGF düzeyi ortalaması açısından anlamlı bir farklılık vardı. (677.1 ± 316.7 vs 492.9 ± 242.7; p = 0.032). Tartışma: +936 C/T SNP'sinin T alleli, azalmış serum VEGF düzeyi ile ilişkilidir ve bu azalma, RAS etiyolojisinde ve patogenezindeki bozulmuş neovaskülarizasyon ve reepitelizayon üzerinde yardımcı bir role sahip olabilir. VEGF'nin RAS yatkınlığı ve onun klinik göstergelerindeki rolünü belirlemek için daha fazla çalışmaya ihtiyaç duyulmaktadır.

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Correlation between histocompatibility antigens and recurrent aphthous stomatitis in the brazilian population

Cited by 14 publications

References 0 publications

Prevalence of oral mucosal disorders in institutionalized and non-institutionalized psychiatric patients: a study from AVBR Hospital in central India

Prevalence of oral mucosal disorders in institutionalized and non-institutionalized psychiatric patients: a study from AVBR Hospital in central India

Beyond Human Leukocyte Antigen Class I Antigens: Hereditary Hemochromatosis Gene Mutations in Recurrent Aphthous Oral Ulcers and Behçet Disease in the South of Tunisia

VEGF, sVEGFR-1 and Endostatin Serum Levels and VEGF Polymorphisms in Recurrent Aphthous Stomatitis

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