Primary progressive aphasia beginning with a psychiatric disorder

Caixeta, Leonardo; Caixeta, Marcelo

doi:10.1590/s1807-59322011000800035

Cited by 7 publications

(6 citation statements)

References 12 publications

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“…In 2016, Marin et al published a study of swallowing problems in 16 PPA patients ( 116 ). Clinical presentations as “psychiatric disorders” have also been reported ( 117 ).…”

Section: Resultsmentioning

confidence: 99%

Frontotemporal Dementias in Latin America: History, Epidemiology, Genetics, and Clinical Research

et al. 2021

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Introduction: The historical development, frequency, and impact of frontotemporal dementia (FTD) are less clear in Latin America than in high-income countries. Although there is a growing number of dementia studies in Latin America, little is known collectively about FTD prevalence studies by country, clinical heterogeneity, risk factors, and genetics in Latin American countries.Methods: A systematic review was completed, aimed at identifying the frequency, clinical heterogeneity, and genetics studies of FTD in Latin American populations. The search strategies used a combination of standardized terms for FTD and related disorders. In addition, at least one author per Latin American country summarized the available literature. Collaborative or regional studies were reviewed during consensus meetings.Results: The first FTD reports published in Latin America were mostly case reports. The last two decades marked a substantial increase in the number of FTD research in Latin American countries. Brazil (165), Argentina (84), Colombia (26), and Chile (23) are the countries with the larger numbers of FTD published studies. Most of the research has focused on clinical and neuropsychological features (n = 247), including the local adaptation of neuropsychological and behavioral assessment batteries. However, there are little to no large studies on prevalence (n = 4), biomarkers (n = 9), or neuropathology (n = 3) of FTD.Conclusions: Future FTD studies will be required in Latin America, albeit with a greater emphasis on clinical diagnosis, genetics, biomarkers, and neuropathological studies. Regional and country-level efforts should seek better estimations of the prevalence, incidence, and economic impact of FTD syndromes.

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“…In 2016, Marin et al published a study of swallowing problems in 16 PPA patients ( 116 ). Clinical presentations as “psychiatric disorders” have also been reported ( 117 ).…”

Section: Resultsmentioning

confidence: 99%

Frontotemporal Dementias in Latin America: History, Epidemiology, Genetics, and Clinical Research

et al. 2021

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“…One case report described a 75-year-old female without any remarkable medical or psychiatric history who developed a full blown panic disorder with agoraphobia at 71 years of age [16]. A year after the panic disorder, the patient exhibited a decline in linguistic fluency, word-finding difficulties, effortful speech and hesitant utterances with frequent pauses, phonemic paraphasias and transpositional errors.…”

Section: Review Of the Literature On Neuropsychiatric Symptoms In Ppamentioning

confidence: 99%

“…Anxiety can be an isolated symptom or a cluster of symptoms severe enough to form an anxiety disorder. In one case report, a patient with no previous anxiety disorder developed a classic panic disorder with agoraphobia, fulfilling DSM criteria, 1 year before the symptoms of PPA slowly emerged [16]. …”

Section: General Synthesis Of Literature On Specific Neuropsychiatricmentioning

confidence: 99%

Neuropsychiatric Symptoms in Primary Progressive Aphasia: phenomenology, pathophysiology, and Approach to Assessment and Treatment

Modirrousta

Price

Dickerson

2013

Neurodegen. Dis. Manage.

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SUMMARY Primary progressive aphasia (PPA) is a neurodegenerative syndrome characterized by insidious and progressive loss of language. Current diagnostic criteria require symptoms to be largely restricted to language dysfunction for at least the first 2 years of the syndrome. However, as the disorder progresses – and sometimes even in the early stages – patients with PPA may exhibit neuropsychiatric symptoms. In this article, we review the phenomenology and frequency of neuropsychiatric symptoms in PPA. Among the few studies of this topic that have been performed, there is consistent agreement that neuropsychiatric symptoms are not uncommon among PPA patients. In some cases, particularly the semantic variant of PPA, symptoms are similar to those found in the behavioral variant of frontotemporal dementia. We further review the approach to assessment of behavioral symptoms in PPA and their possible management strategies, and speculate regarding their potential neurobiological substrates.

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“…On the other hand, our study did not show a significantly higher occurrence of several other symptoms in any of the groups analyzed. Although the literature indicates the occurrence of these symptoms in the studied disorders, such as the occurrence of behavioral symptoms as inaugural symptoms in PPA (21), this characteristic might not be a red flag of the interview with the patient and the caregiver, despite being extremely relevant for the clinical management.…”

Section: Discussionmentioning

confidence: 98%

First Symptoms of Primary Progressive Aphasia and Alzheimer's Disease in Brazilian Individuals

et al. 2021

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Background: Primary Progressive Aphasia (PPA) is characterized by progressive language impairment due to focal degeneration of brain areas related to linguistic processing. The detection and differential diagnosis of PPA can be difficult with clinical features that may overlap with features of other neurological conditions, such as Alzheimer's disease (AD). The scientific production on PPA in Latin American patients is still scarce. This study investigated the first symptoms in a Brazilian sample of patients with PPA in comparison with AD patients.Method: We compared the first symptoms reported by caregivers of people with PPA (n = 20; semantic variant n = 8, non-fluent variant n = 7, logopenic variant n = 3, and unclassified cases n = 2) and AD (n = 16). Data were collected through the application of a structured questionnaire that was presented in an interview format to the caregiver who knew the patient best.Results: Anomia, paraphasias and motor speech difficulties were the first symptoms capable of differentiating patients with PPA from those with AD, while memory was exclusive of AD. Among the PPA variants, anomia was the initial symptom associated with the semantic variant, while motor speech difficulties were associated with the non-fluent variant. The results are discussed considering the unique cultural and sociodemographic characteristics of this studied population.Conclusion: This study demonstrated that some of the initial symptoms of PPA patients may be unique to clinical variants of PPA and of AD, and their investigation may be useful for the early and differential diagnosis of this population.

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Primary progressive aphasia beginning with a psychiatric disorder

Cited by 7 publications

References 12 publications

Frontotemporal Dementias in Latin America: History, Epidemiology, Genetics, and Clinical Research

Frontotemporal Dementias in Latin America: History, Epidemiology, Genetics, and Clinical Research

Neuropsychiatric Symptoms in Primary Progressive Aphasia: phenomenology, pathophysiology, and Approach to Assessment and Treatment

First Symptoms of Primary Progressive Aphasia and Alzheimer's Disease in Brazilian Individuals

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