Hypoparathyroidism mimicking ankylosing spondylitis and myopathy: a case report

Kajitani, Thayana Ribeiro; Silva, Renata Viana da; Bonfá, Eloísa; Pereira, Rosa Maria Rodrigues

doi:10.1590/s1807-59322011000700028

Cited by 12 publications

(18 citation statements)

References 16 publications

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“…[85][86][87][88][89][90][91][92][93][94][95][96] Neuromuscular exam has revealed additional signs including increased muscle tone 87,94 and decreased distal tendon reflexes. 88,92 Common to all these case reports is a significant elevation of circulating muscle enzyme levels, particularly creatine phosphokinase (CPK), which has been reported at levels 1.5 to 10 times greater than the upper limit of normal.…”

Section: Hypoparathyroidism-associated Myopathymentioning

confidence: 99%

Clinical Manifestations of Hypoparathyroidism

Mannstadt

Mitchell

2015

The Parathyroids

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Section: Hypoparathyroidism-associated Myopathymentioning

confidence: 99%

Clinical Manifestations of Hypoparathyroidism

Mannstadt

Mitchell

2015

The Parathyroids

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“…The patient fulfilled the modified New York criteria for ankylosing spondylitis. 12 Bone fusions in the cervical spine, calcification of ligaments and syndesmophytes in the lumbar spine were observed through spine radiography ( Figure 5) and Grade II (right)/Grade III (left) sacroiliitis was observed through sacroiliac joint 13 radiography. Laboratory investigations revealed negative results for autoantibodies and HLA-B27; low serum Calcium, high phosphate and very low serum PTH.…”

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confidence: 97%

“…Treatment with 2 g/day calcium carbonate and 1 µg calcitriol led to evident clinical and laboratory improvement. 13 Goswami R et al assessed clinical characteristics and radiographs of pelvis and spine in 40 consecutive patients with sporadic idiopathic hypoparathyroidism (SIH). Radiographs were assessed by radiologist (RS) and rheumatologist (RG) for the features of spondyloarthropathy including sacroiliitis, syndesmophytes and hip joint calcification, and so on.…”

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confidence: 99%

“…Ossification at the hip joint with preserved joint space is not characteristic of AS but has been reported in HP. 13 The clinical profile, biochemical parameters, and radiological features that aid in differential diagnosis also have a great bearing on patient management. In addition to back pain and stiffness, neuromuscular symptoms like muscle cramps, tetany, and carpopedal spasm are characteristic of idiopathichypoparathyroidism and spondylo-arthropathy but are absent in ankylosing spondylitis and DISH.…”

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confidence: 99%

“…7 Hypoparathyoidism is characterized by low serum Ca, high phosphate and low PTH; whereas these markers have no association with ankylosing spondylitis and DISH. 8,13 The lack of HLA-B27 expression may reduce the likelihood of the AS diagnosis as over 90% of AS patients are positive for this allele. 7 Thus, spondyloarthropathy is a distinct clinical entity in patients with hypoparathyroidism.…”

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Skeletal manifestations of hypoparathyroidism & spondylo-arthropathic features in hypoparathyroidism

et al. 2013

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Hypoparathyroidism is a condition where level of parathyroid in blood isParathyroid glands, as the name suggests, are two pair of small glands situated on the posterior aspect of the thyroid gland. Parathyroid glands secret parathyroid hormone, the hormone responsible for the regulation of serum calcium level within a narrow range. It is the ionized calcium that is the key to maintain the negative feedback. The hormone keeps the serum calcium within the normal range through several mechanisms: by renal calcium reabsorption, and by bringing about active form of 1,25 dihydroxycholecalciferol which in turn causes calcium absorption from gut and also causes renal calcium reabsorption. Thus normal levels of parathormone somewhat regulates normal bone turnover through osteoclastic activity.

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Clinical Manifestations and Diagnosis of Axial Spondyloarthritis

Walsh

Magrey

2020

J Clin Rheumatol

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Background Axial spondyloarthritis (axSpA) is a chronic, rheumatic disease characterized by inflammation of the sacroiliac joint, spine, and entheses. Axial spondyloarthritis affects up to 1.4% of adults in the United States and is associated with decreased quality of life, increased mortality, and substantial health care–related costs, imposing a high burden on patients, their caregivers, and society. Summary of Work Diagnosing axSpA can be difficult. In this review, we seek to help rheumatologists in recognizing and diagnosing axSpA. Major Conclusions A discussion of challenges associated with diagnosis is presented, including use and interpretation of imaging, reasons for diagnostic delays, differences in disease presentation by sex, and differential diagnoses of axSpA. Future Research Directions The early diagnosis of axSpA and advances in available therapeutic options have improved patient care and disease management, but delays in diagnosis and treatment remain common. Additional research and education are critical for recognizing diverse axSpA presentations and optimizing management early in the course of disease.

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Hypoparathyroidism mimicking ankylosing spondylitis and myopathy: a case report

Cited by 12 publications

References 16 publications

Clinical Manifestations of Hypoparathyroidism

Clinical Manifestations of Hypoparathyroidism

Skeletal manifestations of hypoparathyroidism & spondylo-arthropathic features in hypoparathyroidism

Clinical Manifestations and Diagnosis of Axial Spondyloarthritis

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