Introduction: The whole world is on the brink of collapse due to the outbreak of COVID-19 with no solution to treat these cases with any specific drug. Extensive search for the Vaccine or effective treatment is going on while alarming infection and death toll is rising every day.
Aim: The study will compare the effect of Ivermectin with Doxycycline and Hydoxychloroquine with Azythromicin on a selective group of COVID -19 positive patients.
Method: This is a comparative study that included 400 patients of COVID 19 positive patient who were divided in to two groups. Group- A Received Ivermectin with Doxycycline and the other group- B received hydroxichloroquine(HCQ) with azithromycin.
Result: Viral clearance is 132 ( 66%) on day 5 and 167( 83.5% ) on day 6. Among them 33(16.5%) remain PCR positive after 6th day of Ivermectin ingestion in Group A. Whereas there is154 ( 77.0%) viral clearance at 11th day and 163(81.5%) viral clearance at 12th day of Hydroxychloroquine ingestion in Group B. Among them 37 (18.5%) remain PCR positive after 12 day in group B. The P value is 0.000427 which is significant considering 5th day viral clearance of Ivermectin ingestion and 11th day of Hydroxychloroquine ingestion. But considering 6th day and 12th day the P-value is 0.59 which is not significant.
Conclusion: It appears Ivermectin and Doxycycline is safeand effective combination drug therapy in COVID- 19infected patients but need further extensive study to find out the scope of application on other groups of patients.
J Bangladesh Coll Phys Surg 2020; 38(0): 5-9
Hypoparathyroidism is a condition where level of parathyroid in blood isParathyroid glands, as the name suggests, are two pair of small glands situated on the posterior aspect of the thyroid gland. Parathyroid glands secret parathyroid hormone, the hormone responsible for the regulation of serum calcium level within a narrow range. It is the ionized calcium that is the key to maintain the negative feedback. The hormone keeps the serum calcium within the normal range through several mechanisms: by renal calcium reabsorption, and by bringing about active form of 1,25 dihydroxycholecalciferol which in turn causes calcium absorption from gut and also causes renal calcium reabsorption. Thus normal levels of parathormone somewhat regulates normal bone turnover through osteoclastic activity.
Though it is long known that irregular intake of antihypertensive may cause harm, but still there is much lack of awareness among the patients in this matter. This case controlled study was done in Dhaka Medical College Hospital, Dhaka, to determine the relationship between discontinuation of antihypertensive drugs and the risk of stroke among hypertensive patients. Number of cases was 72. Control group was selected via random sampling of stroke free treated hypertensive group, similar in age to stroke cases. Sampling technique was random systematic sampling. The relationship was determined employing statistical methods including Chi-square (?2) test using computer programs, and significant association between discontinuation of antihypertensive and development of stroke in hypertensive adult patients was found ?2(1,N= 103) = 32.637, p<0.001. Odds ratio is 15.83. DOI: http://dx.doi.org/10.3329/jdmc.v22i2.21530 J Dhaka Medical College, Vol. 22, No.2, October, 2013, Page 173-178
Introduction: The burden of kidney disease patients requiring renal replacement therapy is increasing day by day. Hemodialysis (HD) constitutes the most common form of renal replacement therapy (RRT) worldwide. Determining the adequacy of hemodialysis, Urea kinetic modeling (UKM) is an important tool for this. The aim of this study was to determine hemodialysis adequacy by UKM.
Material & Methods: A total 137 patients were sampled in dialysis center of Combined Military Hospital (CMH) Dhaka. This was a cross sectional study. Data were collected from predialysis, postdialysis and next predialysis blood sample. Mean of adequacy parameters like single pool Kt/V (spKt/V), urea reduction ratio (URR), time average concentration of urea (TACurea) and normalized protein catabolic rate (NPCR) were calculated and compared between twice and thrice per week hemodialysis groups. Also compared adequacy variables between groups who achieved cutoff values and who did not achieve it.
Results: One hundred (72.99%) patients were on 8 hours/week and 37 (27%) were on 12 hours/week hemodialysis session. Only 21(21%) and 16(43%) could achieve spKt/V cut off value among 8 hour and 12 hours group respectively. Eighty (58.39%) patients had URR < 65% in this study. Blood flow e+250 ml/ min group had significantly better dialysis adequacy than blood flow <250ml/min group, URR (81.31± 10.21 vs. 54.51 ± 11.52 and p-value <0.001), spKt/V (1.99 ± 0.41 vs. 1.41 ± 0.31 pvalue< 0.001) Thrice weekly hemodialysis group achieved better adequacy than twice weekly group.
Conclusion: Frequency and blood flow of dialysis are strongly associated with adequacy of hemodialysis as evidenced by spKt/V and URR value. So to achieve hemodialysis adequacy, increasing the frequency of dialysis from two to three sessions per week is recommended.
J Bangladesh Coll Phys Surg 2019; 37(4): 169-174
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