Thermographic evaluation of hind paw skin temperature and functional recovery of locomotion after sciatic nerve crush in rats

Sacharuk, Viviane Zechlinski; Lovatel, Gisele Agustini; Ilha, Jocemar; Marcuzzo, Simone; Pinho, Alexandre Severo do; Xavier, Léder Leal; Zaro, Milton Antônio; Achaval, Matilde

doi:10.1590/s1807-59322011000700023

Cited by 14 publications

(9 citation statements)

References 60 publications

(82 reference statements)

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“…[ 70 , 116 , 117 ] Nevertheless, similarly to our findings, this association has not been demonstrated in cases of longstanding lesions. [ 118 ] For example, Sacharuk et al . have demonstrated a normalization of skin temperature in the hindlimb 21 days after a crush injury to the sciatic nerve.…”

Section: Discussionmentioning

confidence: 99%

Reconstruction of a 10-mm-long median nerve gap in an ischemic environment using autologous conduits with different patterns of blood supply: A comparative study in the rat

et al. 2018

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The aim of this study was to evaluate in the Wistar rat the efficacy of various autologous nerve conduits with various forms of blood supply in reconstructing a 10-mm-long gap in the median nerve (MN) under conditions of local ischemia. A 10-mm-long median nerve defect was created in the right arm. A loose silicone tube was placed around the nerve gap zone, in order to simulate a local ischemic environment. Rats were divided in the following experimental groups (each with 20 rats): the nerve Graft (NG) group, in which the excised MN segment was reattached; the conventional nerve flap (CNF) and the arterialized neurovenous flap (ANVF) groups in which the gap was bridged with homonymous median nerve flaps; the prefabricated nerve flap (PNF) group in which the gap was reconstructed with a fabricated flap created by leaving an arteriovenous fistula in contact with the sciatic nerve for 5 weeks; and the two control groups, Sham and Excision groups. In the latter group, the proximal stump of the MN nerve was ligated and no repair was performed. The rats were followed for 100 days. During this time, they did physiotherapy. Functional, electroneuromyographic and histological studies were performed. The CNF and ANVF groups presented better results than the NG group in the following assessments: grasping test, nociception, motor stimulation threshold, muscle weight, and histomorphometric evaluation. Radial deviation of the operated forepaw was more common in rats that presented worse results in the other outcome variables. Overall, CNFs and ANVFs produced a faster and more complete recovery than NGs in the reconstruction of a 10-mm-long median nerve gap in an ischemic environment in the Wistar rat. Although, results obtained with CNFs were in most cases were better than ANVFs, these differences were not statistically significant for most of the outcome variables.

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Section: Discussionmentioning

confidence: 99%

Reconstruction of a 10-mm-long median nerve gap in an ischemic environment using autologous conduits with different patterns of blood supply: A comparative study in the rat

et al. 2018

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“…Another benefit provided by plantar thermography for chronic patients, such as those with DM, is the possibility of following the evolutionary aspects of the disease because thermography allows for functional imaging (60). Because of the strict control of risk factors, such as glycemic control, cutaneous vasomotor functionality of the feet can be monitored periodically using this method.…”

Section: Discussionmentioning

confidence: 99%

Plantar thermography is useful in the early diagnosis of diabetic neuropathy

Balbinot¹,

Canani²,

Robinson³

et al. 2012

Clinics

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OBJECTIVES:This study evaluated plantar thermography sensitivity and specificity in diagnosing diabetic polyneuropathy using cardiac tests (heart rate variability) as a reference standard because autonomic small fibers are affected first by this disease.METHODS:Seventy-nine individuals between the ages of 19 and 79 years old (28 males) were evaluated and divided into three groups: control (n = 37), pre-diabetics (n = 13) and type 2 diabetics (n = 29). The plantar images were recorded at baseline and then minutes after a provocative maneuver (Cold Stress Test) using an infrared camera that is appropriate for clinical use. Two thermographic variables were studied: the thermal recovery index and the interdigital anisothermal technique. Heart rate variability was measured in a seven-test battery that included three spectral indexes (in the frequency domain) and four Ewing tests (the Valsalva maneuver, the orthostatic test, a deep breathing test, and the orthostatic hypotension test). Other classically recommended tests were applied, including electromyography (EMG), Michigan inventory, and a clinical interview that included a neurological physical examination.RESULTS:Among the diabetic patients, the interdigital anisothermal technique alone performed better than the thermal recovery index alone, with a better sensitivity (81.3%) and specificity (46.2%). For the pre-diabetic patients, the three tests performed equally well. None of the control subjects displayed abnormal interdigital anisothermal readouts or thermal recovery indices, which precluded the sensitivity estimation in this sample of subjects. However, the specificity (70.6%) was higher in this group.CONCLUSION:In this study, plantar thermography, which predominately considers the small and autonomic fibers that are commonly associated with a sub-clinical condition, proved useful in diagnosing diabetic neuropathy early. The interdigital anisothermal test, when used alone, performed best.

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“…For assessing locomotor activity, rats were trained to move on a white sheet of paper that covered the bottom of an 8.5-cm wide and 100cm long track in a dark box [30]. Later, the hind feet of the animals were dipped in red dye to track the walk.…”

Section: Determination Of Motor Function Recoverymentioning

confidence: 99%

Myricetin promotes peripheral nerve regeneration in rat model of sciatic nerve injury via regulation of BDNFAkt/ GSK-3β/mTOR signalling pathway

Zhang¹,

Ge²,

Ye³

et al. 2019

Trop. J. Pharm Res

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Purpose:To investigate the effects of myricetin on peripheral nerve regeneration in sciatic nerve crush injury model. Methods: Separate groups of rats were administered myricetin at 25, 50 or 100 mg/kg body weight/day for 2 weeks. Functional recovery following sciatic nerve injury was assessed by foot position and walking track analyses, measurement of mechanical hyperalgesia, and withdrawal reflex latency (WRL). Results: Myricetin treatment resulted in significantly enhanced recovery of sensorimotor functions as evidenced by increased scores in functional analysis tests. Myricetin treatment remarkably elevated brain derived neurotrophic factor (BDNF) expression, and also enhanced activation of Akt and mTORc1, reflecting up-regulation of PI3K/Akt/mTORC1 signalling involved in nerve regeneration. Conclusion: Myricetin enhances functional recovery and nerve regeneration in rats. These findings suggest that myricetin is a potent neuroprotective agent with potential for the management of peripheral nerve injury. This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest

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Thermographic evaluation of hind paw skin temperature and functional recovery of locomotion after sciatic nerve crush in rats

Cited by 14 publications

References 60 publications

Reconstruction of a 10-mm-long median nerve gap in an ischemic environment using autologous conduits with different patterns of blood supply: A comparative study in the rat

Reconstruction of a 10-mm-long median nerve gap in an ischemic environment using autologous conduits with different patterns of blood supply: A comparative study in the rat

Plantar thermography is useful in the early diagnosis of diabetic neuropathy

Myricetin promotes peripheral nerve regeneration in rat model of sciatic nerve injury via regulation of BDNFAkt/ GSK-3β/mTOR signalling pathway

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