Myricetin promotes peripheral nerve regeneration in rat model of sciatic nerve injury via regulation of BDNFAkt/ GSK-3β/mTOR signalling pathway

Zhang, Dechou; Ge, Jian; Ye, Lisha; Tang, Hongmei; Bai, Xue

doi:10.4314/tjpr.v17i12.6

Cited by 4 publications

(2 citation statements)

References 34 publications

(38 reference statements)

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“…Myricetin (3,3′,4′,5,5′,7‐hexahydroxyflavone) is present in various vegetables, fruits, nuts, and red wine. It has potent antioxidant properties (Zhang, Ge, et al., 2018). It has been revealed that myricetin can effectively enhance functional recovery and nerve regeneration by activating the PI3K/AKT/mTORC1/GSK3β signaling pathways following peripheral nerve injury (Zhang, Ge, et al., 2018).…”

Section: Classification Of Natural Compoundsmentioning

confidence: 99%

“…It has potent antioxidant properties (Zhang, Ge, et al., 2018). It has been revealed that myricetin can effectively enhance functional recovery and nerve regeneration by activating the PI3K/AKT/mTORC1/GSK3β signaling pathways following peripheral nerve injury (Zhang, Ge, et al., 2018). It also reduces the ischemic cerebral injury by the protective effects that may be associated with the p38 MAPK, NF‐κB/p65, and AKT signaling pathways.…”

Section: Classification Of Natural Compoundsmentioning

confidence: 99%

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Dietary biomolecules as promising regenerative agents for peripheral nerve injury: An emerging nutraceutical‐based therapeutic approach

et al. 2021

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Peripheral nerve damage is a debilitating condition that can result in partial or complete functional loss as a result of axonal degeneration, as well as lifelong dependence. Many therapies have been imbued with a plethora of positive features while posing little risks. It is worth noting that these biomolecules work by activating several intrinsic pathways that are known to be important in peripheral nerve regeneration. Although the underlying mechanism is used for accurate and speedy functional recovery, none of them are without side effects. As a result, it is believed that effective therapy is currently lacking. The dietary biomolecules‐based intervention, among other ways, is appealing, safe, and effective. Upregulation of transcription factors, neurotrophic factors, and growth factors such as NGF, GDNF, BDNF, and CTNF may occur as a result of these substances' dietary intake. Upregulation of the signaling pathways ERK, JNK, p38, and PKA has also been seen, which aids in axonal regeneration. Although several mechanistic approaches to understanding their involvement have been suggested, more work is needed to reveal the amazing properties of these biomolecules. We have discussed in this article that how different dietary biomolecules can help with functional recovery and regeneration after an injury. Practical applications Based on the information known to date, we may conclude that treatment techniques for peripheral nerve injury have downsides, such as complications, donor shortages, adverse effects, unaffordability, and a lack of precision in efficacy. These difficulties cast doubt on their efficacy and raise severe concerns about the prescription. In this situation, the need for safe and effective therapeutic techniques is unavoidable, and dietary biomolecules appear to be a safe, cost‐efficient, and effective way to promote nerve regeneration following an injury. The information on these biomolecules has been summarized here. Upregulation of transcription factors, neurotrophic factors, and growth factors, such as NGF, GDNF, BDNF, and CTNF, as well as the ERK, JNK, p38, and PKA, signaling pathways, may stimulate axonal regeneration.

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Section: Classification Of Natural Compoundsmentioning

confidence: 99%

Section: Classification Of Natural Compoundsmentioning

confidence: 99%