The potentially dual-faceted nature of fetuin-A in Helicobacter pylori infection and insulin resistance

Polyzos, Stergios A.; Zavos, Christos; Deretzi, Georgia

doi:10.1590/s1807-59322011000500031

Cited by 7 publications

(3 citation statements)

References 7 publications

(20 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is not yet clear if these cytokines/chemokines are the positive regulators of fetuin-A synthesis, as for instance HMGB1 which is a late-acting proinflammatory mediator and was shown to induce fetuin-A in systemic inflammatory conditions [ 12 – 15 ]. In addition, Polyzos et al commented on the potentially dual faceted nature of fetuin-A in Helicobacter pylori infection and insulin resistance [ 18 ]. Trepanowski et al reported that circulating fetuin-A levels were elevated in conditions like obesity, T2D, non-alcoholic fatty liver disease, and metabolic syndrome while the changes associated with impaired insulin sensitivity and glucose tolerance [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

Plasma fetuin-A/α2-HS-glycoprotein correlates negatively with inflammatory cytokines, chemokines and activation biomarkers in individuals with type-2 diabetes

et al. 2016

View full text Add to dashboard Cite

BackgroundFetuin-A/AHSH is a novel hepatokine that acts as a vascular calcification inhibitor and as an endogenous TLR-4 ligand. Fetuin-A may act as a positive or negative acute phase protein (APP) in disease conditions. The relationship between circulatory fetuin-A and inflammatory biomarkers in type-2 diabetes (T2D) remains controversial. Therefore, the purpose of this study was to determine the plasma fetuin-A levels in 53 T2D (BMI = 29.7 ± 4.5 kg/m2) and 72 non-diabetic individuals (BMI = 28.2 ± 5.8 kg/m2) using premixed 38-plex MAP human cytokine/chemokine magnetic bead immunoassays and the data (mean ± SEM) were statistically analyzed to determine Pearson’s correlation (r) between fetuin-A and detected analytes; P-values ≤0.05 were considered significant.ResultsThe data show that plasma fetuin-A levels were comparable in both groups (P = 0.27) and in T2D individuals, fetuin-A associated negatively (P ≤ 0.05) with a large number of proinflammatory cytokines/chemokines and activation biomarkers including TNF-α, IFN-α2, IFN-γ, IL-1α, IL-1β, IL-1RA, IL-3, IL-4, IL-7, IL-9, IL-12p40/p70, IL-15, CCL-2, CCL-4, CCL-11, CCL-22, CXCL-8, CX3CL-1, EFF-2, EGF, G-CSF, GM-CSF, GRO, sCD40L, and VEGF. In non-diabetics, fetuin-A also correlated positively with certain TH2 cytokines (IL-5, IL-13) and chemokines (CCL-3, CCL-5, CCL-7). Notably, in vitro fetuin-A production was significantly suppressed in HepG2 cells treated with TNF-α, IL-1β, and IFN-γ which supported the clinical findings of a negative association between fetuin A and inflammatory mediators.ConclusionsThe negative association between circulatory fetuin-A and systemic inflammatory mediators in T2D patients suggests that plasma fetuin-A may have predictive significance as a negative APP in metabolic disease.Electronic supplementary materialThe online version of this article (doi:10.1186/s12865-016-0171-y) contains supplementary material, which is available to authorized users.

show abstract

Section: Discussionmentioning

confidence: 99%

Plasma fetuin-A/α2-HS-glycoprotein correlates negatively with inflammatory cytokines, chemokines and activation biomarkers in individuals with type-2 diabetes

et al. 2016

View full text Add to dashboard Cite

show abstract

“…In addition the acutely protective anti-inflammatory effect of fetuin-A has also been well known [24]. As compared by Polyzos et al [7] these above-mentioned studies on the decrease [18] and elevation [19] of fetuin-A, however, markedly differed from each other in terms of patient recruitment (age, BMI) and the methods used to diagnose H. pylori infection [7]. Furthermore, fetuin-A levels differed from each other by four orders of magnitude in the two studies.…”

Section: Discussionmentioning

confidence: 95%

“…In addition its association with obesity [3,4], insulin resistance [5] and metabolic syndrome [6] is also known. There are studies suggesting that a H. pylori increases the risk of development of non-alcoholic fatty liver [7], whereas others debate it [8].…”

Section: Introductionmentioning

confidence: 99%

Serum fetuin-A level is independent of Helicobacter pylori postinfection status in systemic lupus erythematosus

Márkus

Temesszentandrási

Vörös

et al. 2022

AMicr

View full text Add to dashboard Cite

Helicobacter pylori is a common pathogen causing gastric inflammation and malignancy. Fetuin-A is a multifunctional protein that is involved in the regulation of calcification, insulin resistance and inflammation. Reports on serum levels of fetuin-A in acute H. pylori infection are contradictory. We intended to see whether H. pylori post-infection status has a long-term effect on serum fetuin-A levels in a well-characterized series of systemic lupus erythematosus cases. In this cross-sectional study 117 patients with systemic lupus erythematosus were enrolled. Helicobacter infection status and serum fetuin-A concentration were determined by ELISA and radial immunodiffusion, respectively. H. pylori positive patients had higher serum fetuin-A concentration than negative ones: 517 (456–603) vs. 476 (408–544) mg L−1, median (25–75% percentiles), P = 0.020. No other parameters differed between these groups. During univariate regression analysis fetuin-A levels were associated with Erythrocyte sedimentation rate (ESR), White blood cell count (WBC), C-reactive protein (CRP), serum total protein, albumin, and the SLEDAI index at the time of diagnosis but only serum albumin remained a significant determinant in multivariate regression study.

show abstract

Complementary and alternative medicinal effects of broccoli sprouts powder on Helicobacter pylori eradication rate in type 2 diabetic patients: A randomized clinical trial

Bahadoran

Mirmiran

Yeganeh

et al. 2014

Journal of Functional Foods

View full text Add to dashboard Cite

The potentially dual-faceted nature of fetuin-A in Helicobacter pylori infection and insulin resistance

Cited by 7 publications

References 7 publications

Plasma fetuin-A/α2-HS-glycoprotein correlates negatively with inflammatory cytokines, chemokines and activation biomarkers in individuals with type-2 diabetes

Plasma fetuin-A/α2-HS-glycoprotein correlates negatively with inflammatory cytokines, chemokines and activation biomarkers in individuals with type-2 diabetes

Serum fetuin-A level is independent of Helicobacter pylori postinfection status in systemic lupus erythematosus

Complementary and alternative medicinal effects of broccoli sprouts powder on Helicobacter pylori eradication rate in type 2 diabetic patients: A randomized clinical trial

Contact Info

Product

Resources

About