Complementary and alternative medicinal effects of broccoli sprouts powder on Helicobacter pylori eradication rate in type 2 diabetic patients: A randomized clinical trial

Bahadoran, Zahra; Mirmiran, Parvin; Yeganeh, Marjan Zarif; Hosseinpanah, Farhad; Zojaji, Homayoun; Azizi, Fereidoun

doi:10.1016/j.jff.2014.01.020

Cited by 17 publications

(9 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, the daily intake of sulforaphane-rich broccoli sprouts for 2 months was demonstrated to reduce gastric bacterial colonization and attenuate gastritis in Helicobacter pylori-infected mice and patients [23]. In another clinical trial, the high-sulforaphane broccoli sprouts powder also showed a considerable effect on H. pylori eradication in type 2 diabetic patients with positive H. pylori [112].…”

Section: Antimicrobial Activitymentioning

confidence: 95%

Bioactive Compounds and Bioactivities of Brassica oleracea L. var. Italica Sprouts and Microgreens: An Updated Overview from a Nutraceutical Perspective

Chiu

Hsieh

2020

Plants

View full text Add to dashboard Cite

Sprouts and microgreens, the edible seedlings of vegetables and herbs, have received increasing attention in recent years and are considered as functional foods or superfoods owing to their valuable health-promoting properties. In particular, the seedlings of broccoli (Brassica oleracea L. var. Italica) have been highly prized for their substantial amount of bioactive constituents, including glucosinolates, phenolic compounds, vitamins, and essential minerals. These secondary metabolites are positively associated with potential health benefits. Numerous in vitro and in vivo studies demonstrated that broccoli seedlings possess various biological properties, including antioxidant, anticancer, anticancer, antimicrobial, anti-inflammatory, anti-obesity and antidiabetic activities. The present review summarizes the updated knowledge about bioactive compounds and bioactivities of these broccoli products and discusses the relevant mechanisms of action. This review will serve as a potential reference for food selections of consumers and applications in functional food and nutraceutical industries.

show abstract

Section: Antimicrobial Activitymentioning

confidence: 95%

Bioactive Compounds and Bioactivities of Brassica oleracea L. var. Italica Sprouts and Microgreens: An Updated Overview from a Nutraceutical Perspective

Chiu

Hsieh

2020

Plants

View full text Add to dashboard Cite

show abstract

“…Our initial observations in vitro and in an animal model [11] have been translated to some eradication and more importantly, reduction of the levels of H. pylori colonization and gastric inflammation in some infected individuals [115,116,117];…”

Section: Broccoli-based Clinical Trialsmentioning

confidence: 99%

Broccoli or Sulforaphane: Is It the Source or Dose That Matters?

et al. 2019

View full text Add to dashboard Cite

There is robust epidemiological evidence for the beneficial effects of broccoli consumption on health, many of them clearly mediated by the isothiocyanate sulforaphane. Present in the plant as its precursor, glucoraphanin, sulforaphane is formed through the actions of myrosinase, a β-thioglucosidase present in either the plant tissue or the mammalian microbiome. Since first isolated from broccoli and demonstrated to have cancer chemoprotective properties in rats in the early 1990s, over 3000 publications have described its efficacy in rodent disease models, underlying mechanisms of action or, to date, over 50 clinical trials examining pharmacokinetics, pharmacodynamics and disease mitigation. This review evaluates the current state of knowledge regarding the relationships between formulation (e.g., plants, sprouts, beverages, supplements), bioavailability and efficacy, and the doses of glucoraphanin and/or sulforaphane that have been used in pre-clinical and clinical studies. We pay special attention to the challenges for better integration of animal model and clinical studies, particularly with regard to selection of dose and route of administration. More effort is required to elucidate underlying mechanisms of action and to develop and validate biomarkers of pharmacodynamic action in humans. A sobering lesson is that changes in approach will be required to implement a public health paradigm for dispensing benefit across all spectrums of the global population.

show abstract

“… ●Low GR B (6.9 μmol/g dry wt.) 48 (84 day) Biomarkers of CVD risk; ↓variation in lipid and a.a. metabolites and TCA cycle intermediates suggesting altered control points Armah et al, 2013 BSE (SFR) 450 μmol SF/day delivered in cheese-based soup ●SF, ●SF+RIF, ●RIF (rifampicin) 24 (7 days x 3) Subjects – healthy volunteers characterized for CYP3A4 status: SF treatment did not affect CYP3A4 activity Poulton et al, 2013 BSP (SFR) ●Standard triple therapy ●BSP (135 μmol SF/d) b ●BSP + triple therapy 86 (28 days) Subjects – type 2 diabetes / H. pylori infected patients: Considerable ↓ H. pylori infection, and ↓pro-inflammatory markers, but no complete eradication Bahadoran et al, 2014 BSE (SFR) ●100 μmol SF/d delivered in mango juice 29 (4 days BSE trtmnt) Subjects challenged with an irritation/allergy-provoking diesel exhaust particle (DEP) suspension; white blood cell counts declined by 54% when DEP challenge was preceded by daily BSE admin for 4 days Heber et al., 2014a , Heber et al., 2014b BSE (SFR) ●200 μmol SF/d 20 (≤140 days) Subjects – men with biochemical recurrence of prostate cancer: PSA doubling time was 9.6 mo. on-trtmnt, vs. 6.1 mo.…”

Section: Demonstrating Pharmacodynamic Action Of Sulforaphane In Humamentioning

confidence: 99%

KEAP1 and done? Targeting the NRF2 pathway with sulforaphane

Dinkova‐Kostova

Fahey

Kostov

et al. 2017

Trends in Food Science & Technology

217

143

View full text Add to dashboard Cite

BackgroundSince the re-discovery of sulforaphane in 1992 and the recognition of the bioactivity of this phytochemical, many studies have examined its mode of action in cells, animals and humans. Broccoli, especially as young sprouts, is a rich source of sulforaphane and broccoli-based preparations are now used in clinical studies probing efficacy in health preservation and disease mitigation. Many putative cellular targets are affected by sulforaphane although only one, KEAP1-NRF2 signaling, can be considered a validated target at this time. The transcription factor NRF2 is a master regulator of cell survival responses to endogenous and exogenous stressors.Scope and ApproachThis review summarizes the chemical biology of sulforaphane as an inducer of NRF2 signaling and efficacy as an inhibitor of carcinogenesis. It also provides a summary of the current findings from clinical trials using a suite of broccoli sprout preparations on a series of short-term endpoints reflecting a diversity of molecular actions.Key Findings and ConclusionsSulforaphane, as a pure chemical, protects against chemical-induced skin, oral, stomach, colon, lung and bladder carcinogenesis and in genetic models of colon and prostate carcinogenesis. In many of these settings the antitumorigenic efficacy of sulforaphane is dampened in Nrf2-disrupted animals. Broccoli preparations rich in glucoraphanin or sulforaphane exert demonstrable pharmacodynamic action in over a score of clinical trials. Measures of NRF2 pathway response and function are serving as guideposts for the optimization of dose, schedule and formulation as clinical trials with broccoli-based preparations become more commonplace and more rigorous in design and implementation.

show abstract

Complementary and alternative medicinal effects of broccoli sprouts powder on Helicobacter pylori eradication rate in type 2 diabetic patients: A randomized clinical trial

Cited by 17 publications

References 32 publications

Bioactive Compounds and Bioactivities of Brassica oleracea L. var. Italica Sprouts and Microgreens: An Updated Overview from a Nutraceutical Perspective

Bioactive Compounds and Bioactivities of Brassica oleracea L. var. Italica Sprouts and Microgreens: An Updated Overview from a Nutraceutical Perspective

Broccoli or Sulforaphane: Is It the Source or Dose That Matters?

KEAP1 and done? Targeting the NRF2 pathway with sulforaphane

Contact Info

Product

Resources

About