Serum levels of hypothalamic-pituitary-testicular axis hormones in men with or without prostate cancer or atypical small acinar proliferation

Schmitt, Caio da Silva; Rhoden, Ernani Luı́s; Almeida, Gilberto Laurino

doi:10.1590/s1807-59322011000200001

Cited by 5 publications

(2 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Four studies in this systematic review used self-identification (color choice made by the respondent) as the methodology to classify the participants in different racial/ethnic groups (5,14,15,20). All other studies apparently used hetero-identification (color attribution assigned by the interviewer to the respondent).…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

The prevalence of prostate cancer in Brazil is higher in Black men than in White men: systematic review and meta-analysis

Romero

Almeida

et al. 2012

Int. braz j urol.

View full text Add to dashboard Cite

INTRODUcTIONProstate cancer is the most common form of noncutaneous cancer in men and the second leading cause of male cancer mortality. The incidence of prostate cancer varies according to racial/ethnic differences in several countries (1). The estimated incidence of prosBackground: Black men have a higher incidence of prostate cancer compared with White men in several countries. In Brazil, most studies reported a similar prevalence of prostate cancer between Blacks and Whites as a result of the high race mixture of the population. Objective: To perform a systematic review with meta-analysis of the prevalence of prostate cancer in Black versus White, Brown versus White, and Black versus Brown Brazilian men. Design, Setting, and Participants: This systematic review included cohort, cross sectional and case-control studies comparing the prevalence of prostate cancer between races in Brazil. It was performed using an electronic search of references in bibliographic databases, and dissertations and theses databases from several Brazilian hospitals, universities, and schools of medicine. Meta-analysis was conducted using the RevMan software from the Cochrane Collaboration. To control for potential confounding variables, sensitivity analyses excluding case-control and cross sectional studies were performed. Measurements: The outcomes of interest included the number of participants, prevalence of prostate cancer, and odds ratio of cancer between Black and White men, Brown and White men, and Black and Brown men. Results and Limitations: : Twelve studies approaching the prevalence of prostate cancer in Black or Brown vs. White men in Brazil were identifi ed, totalizing 41388 participants. The prevalence of prostate cancer was 9.6% in Black vs. 5.6% in White men (OR 1.58), 10.1% in Black vs. 6.7% in Brown men (OR 1.43), and 6.7% in Brown vs. 6.6% in White men (OR 1.14). Limitations of this review refl ect the complexity and ambiguity in the defi nition of who is Black and who is not in such an heterogeneous population like the Brazilian people. Conclusions: This systematic review with meta-analysis demonstrates a higher prevalence of prostate cancer in Black men compared to White or Brown Brazilian men. The prevalence of prostate cancer is similar in Brown versus White men.

show abstract

Section: Resultsmentioning

confidence: 99%

“…(15,(20)(21)(22) One study included as Black individuals with all kinds of skin pigmentation if they had African ancestry. (5).…”

Section: Resultsmentioning

confidence: 99%

The prevalence of prostate cancer in Brazil is higher in Black men than in White men: systematic review and meta-analysis

Romero

Almeida

et al. 2012

Int. braz j urol.

View full text Add to dashboard Cite

show abstract

The hypothalamic–pituitary–gonadal axis and prostate cancer: implications for androgen deprivation therapy

et al. 2013

View full text Add to dashboard Cite

Luteinizing hormone (LH) and follicle-stimulating hormone (FSH) may play important roles in prostate cancer (PCa) progression. Specifically, LH expression in PCa tissues has been associated with metastatic disease with a poor prognosis, while FSH has been shown to stimulate prostate cell growth in hormone-refractory PCa cell lines. Gonadotropin-realizing hormone (GnRH) analogues are common agents used for achieving androgen deprivation in the treatment for PCa. GnRH analogues include LH-releasing hormone (LHRH) agonists and GnRH antagonists, both of which exhibit distinct mechanisms of action that may be crucial in terms of their overall clinical efficacy. LHRH agonists are typically used as the primary therapy for most patients and function via a negative-feedback mechanism. This mechanism involves an initial surge in testosterone levels, which may worsen clinical symptoms of PCa. GnRH antagonists provide rapid and consistent hormonal suppression without the initial surge in testosterone levels associated with LHRH agonists, thus representing an important therapeutic alternative for patients with PCa. The concentrations of testosterone and dihydrotestosterone are significantly reduced after treatment with both LHRH agonists and GnRH antagonists. This reduction in testosterone concentrations to castrate levels results in significant, rapid, and consistent reductions in prostatic-specific antigen, a key biomarker for PCa. Evidence suggests that careful maintenance of testosterone levels during androgen deprivation therapy provides a clinical benefit to patients with PCa, emphasizing the need for constant monitoring of testosterone concentrations throughout the course of therapy.

show abstract

The consequence and mechanism of dietary flavonoids on androgen profiles and disorders amelioration

Deng

et al. 2022

Critical Reviews in Food Science and Nutrition

View full text Add to dashboard Cite

Serum levels of hypothalamic-pituitary-testicular axis hormones in men with or without prostate cancer or atypical small acinar proliferation

Cited by 5 publications

References 26 publications

The prevalence of prostate cancer in Brazil is higher in Black men than in White men: systematic review and meta-analysis

The prevalence of prostate cancer in Brazil is higher in Black men than in White men: systematic review and meta-analysis

The hypothalamic–pituitary–gonadal axis and prostate cancer: implications for androgen deprivation therapy

The consequence and mechanism of dietary flavonoids on androgen profiles and disorders amelioration

Contact Info

Product

Resources

About