The consequence and mechanism of dietary flavonoids on androgen profiles and disorders amelioration

Hu, Xiang; Li, Xusheng; Deng, Pan; Zhang, Yulin; Liu, Ruijing; Cai, Dongbao; Xu, Qingjie; Jiang, Xinwei; Sun, Jianxia; Bai, Weibin

doi:10.1080/10408398.2022.2090893

Cited by 6 publications

(3 citation statements)

References 210 publications

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“…Our findings were consistent with a prior study that discovered gallic acid decreased the expression of 5α-reductase type 1 and 2 [52]. The ability of quercetin to treat androgen disorders is well known [53]. It possesses antiandrogenic activity by diminishing AR expression and its activity [54].…”

Section: Discussionsupporting

confidence: 93%

Guava (Psidium guajava L.) Leaf Extract as Bioactive Substances for Anti-Androgen and Antioxidant Activities

Ruksiriwanich

Khantham

Muangsanguan

et al. 2022

Plants

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Leaves of guava (Psidium guajava L.) have been used in Thai folk medicine without any supporting evidence as a traditional herbal remedy for hair loss. Androgenetic alopecia (AGA) is chronic hair loss caused by effects of androgens in those with a genetic predisposition, resulting in hair follicle miniaturization. Our objectives were to provide the mechanistic assessment of guava leaf extract on gene expressions related to the androgen pathway in well-known in vitro models, hair follicle dermal papilla cells (HFDPC), and human prostate cancer cells (DU-145), and to determine its bioactive constituents and antioxidant activities. LC-MS analysis demonstrated that the main components of the ethanolic extract of guava leaves are phenolic substances, specifically catechin, gallic acid, and quercetin, which contribute to its scavenging and metal chelating abilities. The guava leaf extract substantially downregulated SRD5A1, SRD5A2, and SRD5A3 genes in the DU-145 model, suggesting that the extract could minimize hair loss by inhibiting the synthesis of a potent androgen (dihydrotestosterone). SRD5A suppression by gallic acid and quercetin was verified. Our study reveals new perspectives on guava leaf extract’s anti-androgen properties. This extract could be developed as alternative products or therapeutic adjuvants for the treatment of AGA and other androgen-related disorders.

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Section: Discussionsupporting

confidence: 93%

Guava (Psidium guajava L.) Leaf Extract as Bioactive Substances for Anti-Androgen and Antioxidant Activities

Ruksiriwanich

Khantham

Muangsanguan

et al. 2022

Plants

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“…Estrogen and prolactin could contribute to the development and progression of NSCLC. [16,37] Studies have shown that flavonoid compounds, which share structural similarities with human estrogens, could bind to the estrogen receptors to alter the endocrine responses, [38][39][40] and might exert antagonizing effects on the endocrine resistance in NSCLC. As a typical inflammation-associated cancer, NSCLC could use the Systemic Immune Inflammatory Index as a promising prognostic biomarker.…”

Section: Discussionmentioning

confidence: 99%

The mechanism of Bai He Gu Jin Tang against non-small cell lung cancer revealed by network pharmacology and molecular docking

et al. 2022

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Background: Non-small cell lung cancer (NSCLC) is a leading cause of cancer-related burden and deaths, thus effective treatment strategies with lower side effects for NSCLC are urgently needed. To systematically analyze the mechanism of Bai He Gu Jin Tang (BHGJT) against NSCLC by network pharmacology and molecular docking. Methods: The active compounds of BHGJT were obtained by searching the Bioinformatics Analysis Tool for Molecular Mechanism of Traditional Chinese Medicine and Encyclopaedia of Traditional Chinese Medicine. Search tool for interactions of chemicals was used for acquiring the targets of BHGJT. The component-target network was mapped by Cytoscape. NSCLC-related genes were obtained by searching Genecards, DrugBank and Therapeutic Target Database. The protein-protein interaction network of intersection targets was established based on Search Tool for Recurring Instances of Neighboring Genes (STRING), and further, the therapeutic core targets were selected by topological parameters. The hub targets were transmitted to Database for Annotation, Visualization and Integrated Discovery for gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis. Finally, AutoDock Vina and MglTools were employed for molecular docking validation. Results: Two hundred fifty-six compounds and 237 putative targets of BHGJT-related active compounds as well as 1721potential targets of NSCLC were retrieved. Network analysis showed that 8 active compounds of BHGJT including kaempferol, quercetin, luteolin, isorhamnetin, beta-sitosterol, stigmasterol, mairin and liquiritigenin as well as 15 hub targets such as AKR1B10 and AKR1C2 contribute to the treatment of BHGJT against NSCLC. GO functional enrichment analysis shows that BHGJT could regulate many biological processes, such as apoptotic process. Three modules of the endocrine related pathways including the inflammation, hypoxia related pathways as well as the other cancer related pathways based on Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis might explain the biological mechanisms of BHGJT in treating BHGJT. The results of molecular docking verified that AKR1B10 and AKR1C2 had the strongest binding activity with the 8 key compounds of NSCLC. Conclusion: Our study reveals the mechanism of BHGJT in treating NSCLC involving multiple components, multiple targets and multiple pathways. The present study laid an initial foundation for the subsequent research and clinical application of BHGJT and its active compounds against NSCLC.

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“…In brief, dietary polyphenols have gained increased public interest in recent years due to their anti-inflammatory properties via multiple mechanisms through inhibition of mitogen-activated protein kinases (MAPK) signaling pathways and NFkβ and AP-1 transcription factors, blocking the production of inflammatory cytokines and chemokines, and suppressing the activity of COX-2 and iNOS [ 77 ]. Additionally, a more recent report in 2022 by Hu et al reviewed the properties of polyphenol/flavonoids that can interfere with androgen synthesis and metabolism to regulate androgen hormone actions, thus providing a nutritional intervention to improve androgen disorders such as BPH [ 78 ]. In connection with this perspective, soy isoflavones have been studied and reviewed for their protective effects on BPH and prostate cancer [ 60 , 61 , 69 , 72 , 79 ] which include all the positive multiple mechanisms of actions outlined by Eleazu et al above [ 77 ].…”

Section: Factors Influencing Bphmentioning

confidence: 99%

Overview of BPH: Symptom Relief with Dietary Polyphenols, Vitamins and Phytochemicals by Nutraceutical Supplements with Implications to the Prostate Microbiome

Stewart

Lephart

2023

IJMS

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Benign prostatic hyperplasia (BPH) is an age-related disorder, which is one of the most prevalent and costly benign neoplasms in men with over 94 million cases worldwide. Starting before or around 50 years of age, there is a linear increase in prostate volume and BPH symptoms, which are influenced by changes in hormonal, inflammatory, growth factors, cell receptor signaling, diet, physical activity, and the microbiome of the prostate that leads to cellular proliferation. While current pharmaceutical or surgical treatments are currently available, each treatment has serious side effects. This dilemma has motived men to seek treatment without negative side effects from medicinal plants such as botanicals, phytochemicals, and vitamins that have established safety records. This narrative overview focuses on several botanicals, phytochemicals and vitamins that are widely used in the treatment of BPH and emphasizes how, in some cases, combinations of these natural ingredients may provide better BPH symptom relief compared to utilization of a single medicinal plant product (monotherapy). Finally, this overview highlights in vitro, in vivo animal studies and mainly clinical data of journal reports published in the past 5 years from January 2018 to January 2023 on BPH and nutraceuticals. Notably, there is an evolving perspective or rethinking of the role that medicinal phytochemicals and natural vitamins usage play; that is, they may hold promise or are likely to alleviate BPH symptoms.

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The consequence and mechanism of dietary flavonoids on androgen profiles and disorders amelioration

Cited by 6 publications

References 210 publications

Guava (Psidium guajava L.) Leaf Extract as Bioactive Substances for Anti-Androgen and Antioxidant Activities

Guava (Psidium guajava L.) Leaf Extract as Bioactive Substances for Anti-Androgen and Antioxidant Activities

The mechanism of Bai He Gu Jin Tang against non-small cell lung cancer revealed by network pharmacology and molecular docking

Overview of BPH: Symptom Relief with Dietary Polyphenols, Vitamins and Phytochemicals by Nutraceutical Supplements with Implications to the Prostate Microbiome

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