Passive stiffness of rat skeletal muscle undernourished during fetal development

Toscano, Ana Elisa; Ferraz, Karla Mônica; Castro, Raul Manhães de; Canon, Francis

doi:10.1590/s1807-59322010001200022

Cited by 22 publications

(20 citation statements)

References 34 publications

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“…Figures 5e and f show this helical thin-film transistor array before and after 50% stretching. To mimic the ‘J-shaped’ stress–strain behavior of the muscle 118, 119 , Haines et al 120 proposed a type of artificial muscle by using the nylon 6,6 coil fibers show in Figures 5g-j.…”

Section: Helical Designmentioning

confidence: 99%

Design and application of ‘J-shaped’ stress–strain behavior in stretchable electronics: a review

et al. 2017

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A variety of natural biological tissues (e.g., skin, ligaments, spider silk, blood vessel) exhibit ‘J-shaped’ stress-strain behavior, thereby combining soft, compliant mechanics and large levels of stretchability, with a natural ‘strain-limiting’ mechanism to prevent damage from excessive strain. Synthetic materials with similar stress-strain behaviors have potential utility in many promising applications, such as tissue engineering (to reproduce the nonlinear mechanical properties of real biological tissues) and biomedical devices (to enable natural, comfortable integration of stretchable electronics with biological tissues/organs). Recent advances in this field encompass developments of novel material/structure concepts, fabrication approaches, and unique device applications. This review highlights five representative strategies, including designs that involve open network, wavy and wrinkled morphoologies, helical layouts, kirigami and origami constructs, and textile formats. Discussions focus on the underlying ideas, the fabrication/assembly routes, and the microstructure-property relationships that are essential for optimization of the desired ‘J-shaped’ stress-strain responses. Demonstration applications provide examples of the use of these designs in deformable electronics and biomedical devices that offer soft, compliant mechanics but with inherent robustness against damage from excessive deformation. We conclude with some perspectives on challenges and opportunities for future research.

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Section: Helical Designmentioning

confidence: 99%

Design and application of ‘J-shaped’ stress–strain behavior in stretchable electronics: a review

et al. 2017

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“…However, in these large regions of κ, the model surface will be far from biological membranes. The nominal stress vs. strain ( ) of (a) blood vessel [5], (b) rat muscle [6], (c) collagen fibers [7] and (d) collagen hydrogels [8]. The solid triangle denotes the simulation data τ sim of Eq.…”

Section: Eq (15)mentioning

confidence: 99%

“…In this subsection, we show that the simulation data can be compared to experimental stress-strain data of biological materials such as blood vessel, rat muscle, collagen fibers, and collagen hydrogels [5][6][7][8] (see Figs. 10(a)-(d)).…”

Section: Eq (15)mentioning

confidence: 99%

J-shaped stress-strain diagram of collagen fibers: Frame tension of triangulated surfaces with fixed boundaries

Takano

Koibuchi

2017

Phys. Rev. E

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We present Monte Carlo data of the stress-strain diagrams obtained using two different triangulated surface models. The first is the canonical surface model of Helfrich and Polyakov (HP), and the second is a Finsler geometry (FG) model. The shape of the experimentally observed stressstrain diagram is called J-shaped. Indeed, the diagram has a plateau for the small strain region and becomes linear in the relatively large strain region. Because of this highly non-linear behavior, the J-shaped diagram is far beyond the scope of the ordinary theory of elasticity. Therefore, the mechanism behind the J-shaped diagram still remains to be clarified, although it is commonly believed that the collagen degrees of freedom play an essential role. We find that the FG modeling technique provides a coarse-grained picture for the interaction between the collagen and the bulk material. The role of the directional degrees of freedom of collagen molecules or fibers can be understood in the context of FG modeling. We also discuss the reason for why the J-shaped diagram cannot (can) be explained by the HP (FG) model. *

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“…However, a reduction in the maximal twitch and tetanic force has been demonstrated in EDL muscles of 25- to 90-day-old rats that were gestationally undernourished with low-protein diets [43]. The same model has also been used to demonstrate that passive tension is increased in EDL and soleus muscles, indicating that prenatal undernourishment also affects the passive elastic components [44]. We considered that the effect of gestational undernourishment measured at birth would have a direct effect on SM function because there is no further feeding or environmental conditioning.…”

Section: Discussionmentioning

confidence: 99%

Gestational Undernourishment Modifies the Composition of Skeletal Muscle Transverse Tubule Membranes and the Mechanical Properties of Muscles in Newborn Rats

Ramírez-Oseguera¹,

Jiménez-Garduño²,

Álvarez³

et al. 2013

Cell Physiol Biochem

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Backgroud/Aims: Skeletal muscle (SM) constitutes more than 40% of the body weight in adulthood. Transports dietary glucose mainly through the insulin-dependent glucose transporter (Glut-4) located in the Transverse tubule membrane system (TT). The TT development ends shortly after birth. The TT membrane hosts the proteins involved in excitation-contraction coupling and glucose uptake. Glycaemic regulation through movement is a key function of fully developed skeletal muscle. In this study, we aimed to characterize the effect of gestational undernourishment (GUN) in rats GLUT-4 expression and on the protein/lipid content of the TT membranes. We also examined the effect of GUN on the mechanical properties of muscles as an indication of the metabolic condition of the SM at birth. Methods: Isolated TT membrane from SM of GUN rats were used to study lipid/protein content and protein stability by differential scanning calorimetry. The effect of GUN on the SM mechanical properties was determined in isolated Extensor Digitorum Longus (EDL) muscle. Results: We demonstrate that compared to control, GUN in the new-born produces; i) decreases body weight; ii) diminution in SM mass; iii) decreases the formation of TT membranes; iv) expresses TT membrane proteins with higher thermal stability. The TT membrane expression of GLUT-4 in GUN offspring was twice that of controls. The isolated EDL of GUN offspring was 20% stronger as measured by contractile force and more resistant to fatigue relative to controls. Conclusion; These results provide the first evidence of adaptive changes of the SM in new-borns exposed to severe gestational food restriction. The effects of GUN on muscle at birth are the first step toward detrimental SM metabolic function, contributing to the physiopathology of metabolic diseases in adulthood.

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Passive stiffness of rat skeletal muscle undernourished during fetal development

Cited by 22 publications

References 34 publications

Design and application of ‘J-shaped’ stress–strain behavior in stretchable electronics: a review

Design and application of ‘J-shaped’ stress–strain behavior in stretchable electronics: a review

J-shaped stress-strain diagram of collagen fibers: Frame tension of triangulated surfaces with fixed boundaries

Gestational Undernourishment Modifies the Composition of Skeletal Muscle Transverse Tubule Membranes and the Mechanical Properties of Muscles in Newborn Rats

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