Piper Sarmentosum Increases Nitric Oxide Production in Oxidative Stress: A Study on Human Umbilical Vein Endothelial Cells

Ugusman, Azizah; Zakaria, Zaiton; Chua, Kien Hui; Nordin, Nor Anita Megat Mohd

doi:10.1590/s1807-59322010000700010

Cited by 33 publications

(36 citation statements)

References 25 publications

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“…In fact, while a significant increase in NO -iNOS-produced-participates in provoking inflammatory process [137], a low NO bioavailabilityeNOS produced-is central to the development and maintenance of hypertension and related endothelial dysfunction [138]. Consequently, the inhibition of excessive inducible NO production may be an anti-inflammatory therapeutic target, and the protection against a decrease in constitutive NO production in the vasculature may prevent the development of atherosclerosis and endothelial dysfunction [135,139]. PCA appears to significantly reduce iNOS protein expression and NO production both in vitro and in vivo.…”

Section: Pca and Nitric Oxidementioning

confidence: 99%

Protocatechuic Acid and Human Disease Prevention: Biological Activities and Molecular Mechanisms

Santangelo²,

et al. 2012

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Epidemiological evidence has shown that a high dietary intake of vegetables and fruit rich in polyphenols is associated with a reduction of cancer incidence and mortality from coronary heart disease. The healthy effects associated with polyphenol consumption have made the study of the mechanisms of action a matter of great importance. In particular, the hydroxybenzoic acid protocatechuic acid (PCA) has been eliciting a growing interest for several reasons. Firstly, PCA is one of the main metabolites of complex polyphenols such as anthocyanins and procyanidins that are normally found at high concentrations in vegetables and fruit, and are absorbed by animals and humans. Since the daily intake of anthocyanins has been estimated to be much higher than that of other polyphenols, the nutritional value of PCA is increasingly recognized. Secondly, a growing body of evidence supports the concept that PCA can exert a variety of biological effects by acting on different molecular targets. It has been shown that PCA possesses antioxidant, anti-inflammatory as well as antihyperglycemic and neuroprotective activities. Furthermore, PCA seems to have chemopreventive potential because it inhibits the in vitro chemical carcinogenesis and exerts pro-apoptotic and anti-proliferative effects in different tissues. This review is aimed at providing an up-dated and comprehensive report on PCA giving a special emphasis on its biological activities and the molecular mechanisms of action most likely responsible for a beneficial role in human disease prevention.

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Section: Pca and Nitric Oxidementioning

confidence: 99%

Protocatechuic Acid and Human Disease Prevention: Biological Activities and Molecular Mechanisms

Santangelo²,

et al. 2012

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“…Previous research had shown that PS has cardiovascular protective effects. It showed the ability to increase nitric oxide production in human umbilical vein endothelial cells (HUVECs) [9, 10] and antiatherosclerotic property. In 2012, a study showed that PS aqueous extract was able to remodel ultrastructure stability of the cardiovascular tissue in the Streptozotocin-induced diabetic rats [11].…”

Section: Introductionmentioning

confidence: 99%

Does Oral Ingestion ofPiper sarmentosumCause Toxicity in Experimental Animals?

Zainudin

Zakaria

Nordin

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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The prevalence of diabetes mellitus has reached epidemic proportion in Malaysia and worldwide. Scientific studies have shown that herbal plant Piper sarmentosum exhibits an antidiabetic property. Despite the extensive usage and studies of this herb as alternative medicine, there is paucity of the literature on the safety information of this plant. Thus, the present study aimed to observe the subacute toxic effects of Piper sarmentosum aqueous extract (PSAE) on the haematological profile, liver, and kidney in rats. The extract was administered by oral gavage to 6 male and female Sprague Dawley rats in daily dose of 50 mg/kg, 300 mg/kg, and 2000 mg/kg for 28 consecutive days. The control group received normal saline. General behavior of the rats, adverse effects, and mortality were observed for 28 days. The haematological and biochemical parameters were determined at baseline and after the treatment. PSAE did not show abnormality on the body weight and gross observation of internal organs. The haematological, biochemical and histopathological profiles showed minimal changes and variation within normal clinical range except for significant increase in serum potassium level that suggests the need of regular monitoring. Nevertheless, these findings suggested that PSAE up to 2000 mg/kg/day did not show subacute toxicity in Sprague Dawley rats.

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“…Ten percent aqueous extract of the plant in a dose of 150 µg/mL has shown marked induction of NO in HUVECs (Ugusman et al, 2010).…”

Section: Antioxidant Activitiesmentioning

confidence: 96%

A review of the literature and latest advances in research ofPiper sarmentosum

Hussain

Hashmi

Latif

et al. 2012

Pharmaceutical Biology

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Piper Sarmentosum Increases Nitric Oxide Production in Oxidative Stress: A Study on Human Umbilical Vein Endothelial Cells

Cited by 33 publications

References 25 publications

Protocatechuic Acid and Human Disease Prevention: Biological Activities and Molecular Mechanisms

Protocatechuic Acid and Human Disease Prevention: Biological Activities and Molecular Mechanisms

Does Oral Ingestion ofPiper sarmentosumCause Toxicity in Experimental Animals?

A review of the literature and latest advances in research ofPiper sarmentosum

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