Reversible Serum Carcinoembriogenic Antigen (CEA) Elevation Due to Orlistat Use: A Case Report

Fernandes, Gustavo dos Santos; Katz, Atur; Calabrich, Aknar; Hoff, Paulo M.

doi:10.1590/s1807-59322010000600013

Cited by 2 publications

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References 6 publications

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“…To our knowledge and literature search, this is the first case report linking lithium with an elevated CEA level. Ferandes G et al, reported a case of CEA elevation with orlistat, which resolved after discontinuation of orlistat [ 7 ]. The underlying pathophysiology by which orlistat led to CEA elevation was unclear.…”

Section: Discussionmentioning

confidence: 99%

Elevated Level of Serum Carcinoembryonic Antigen (CEA) and Search for a Malignancy: A Case Report

Asad-Ur-Rahman

Saif

2016

Cureus

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Carcinoembryonic antigen (CEA) has been shown to be associated with tumor burden in patients with colorectal cancer. However, it is also elevated to a significant degree in a number of other malignant and non-malignant conditions. We report a case of reversible CEA elevation in a patient using lithium for bipolar disorder.A 58-year-old female with a longstanding smoking history and a past medical history of chronic obstructive pulmonary disease (COPD), bipolar illness, hypothyroidism, and obesity was found to have an elevated CEA level of 11.2 ng/ml (normal level <5 ng/ml) in the workup for postmenopausal bleeding. Her history was not positive for malignancy of colorectum, ovaries, thyroid, or breast. She underwent a large number of imaging and endoscopic studies to evaluate for colorectal, breast, ovarian, and lung cancer; however, it did not reveal any evidence of malignancy. Upon review of her medications, she reported that she had recently started lithium for her bipolar illness. We followed up her CEA level while her dose of lithium was reduced from 450 to 300 mg per day. Her CEA level decreased from 25 mg/dl to 6.1 mg/dl and remained stable over the course of the next eight months.Our case is the first case report that identifies lithium as a potential cause of reversible CEA elevation. The underlying mechanism is yet to be elucidated, but it underscores the importance of investigating the medications as part of the workup.

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Section: Discussionmentioning

confidence: 99%