A forgotten but important risk factor for severe hyponatremia: myxedema coma

Kargılı, Ayşe; Turgut, Faruk; Karakurt, Feridun; Kasapoğlu, Benan; Kanbay, Mehmet; Akçay, Ali

doi:10.1590/s1807-59322010000400015

Cited by 8 publications

(4 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It can lead to a variety of clinical situations, including congestive heart failure, electrolyte disturbances and coma. Hyponatremia is the most common electrolyte abnormality encountered in clinical practice [15]. Thyroid hormone is a central regulator of body haemodynamics, thermoregulation and metabolism.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Serum Minerals and Electrolytes In Thyroid Patients

Shrestha¹,

Bharti²,

Rai³

et al. 2015

Int J of Adv in Sci Res

View full text Add to dashboard Cite

Introduction: The effect on thyroid hormones on electrolytes and minerals has not been well established and the underlying mechanisms are not well understood. Only few data on the association between thyroid function and electrolyte disorders exists. Thus our aim was to assess the levels of serum electrolytes and minerals in the patients with thyroid disorders. Materials and methods: 75 patients and 30 controls were included. Thyroid hormones (T3, T4, TSH) were measured by vidas autoanalyser. Serum calcium, phosphorous and magnesium were estimated by kit based method using semiautoanalyser. Serum sodium, potassium and chlorides were estimated using ion selective electrodes. Statistical analysis was done using SPSS 16. Results: Patients with subclinical hypothyroidism and overt hypothyroidism showed significant decrease in serum calcium and sodium levels and significant increase in serum phosphorous, magnesium, potassium and chloride levels (p<0.05). In case of subclinical hyperthyroidism significant difference could not be obtained among controls and patients (p>0.05). However for overt hyperthyroid patients, serum phosphorous was significantly decreased and serum sodium was increased significantly (p<0.05). Rest of the results were non significant. When correlated with TSH, serum calcium and sodium showed negative correlation whereas it was positive for serum phosphorous, magnesium, potassium and chloride in case of hypothyroidism. For hyperthyroid patients, correlation was negative for magnesium and chloride whereas positive for the rest parameters. But none of correlations were statistically significant (p>0.05). Conclusion: Thyroid patients should be regularly checked for serum electrolytes. Early detection and treatment can prevent the further complications and will be helpful during the management of thyroid patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Assessment of Serum Minerals and Electrolytes In Thyroid Patients

Shrestha¹,

Bharti²,

Rai³

et al. 2015

Int J of Adv in Sci Res

View full text Add to dashboard Cite

show abstract

“…Hypothyroidism, a common hormonal disorder has been strongly linked to thyroid hormone secretion and metabolic rate (9). These hormones affect protein, carbohydrates and fat metabolism and decreased hormonal levels could result in clinical conditions such as decreased fertility, coma, congestive heart failure, and electrolyte abnormalities (7). The significantly increase in TSH levels seen in cases as compared to normal subjects in this study, could be attributed to the deregulation of the hypothalamus pituitary axis causing neuroendocrine dysfunction (8).…”

Section: Discussionmentioning

confidence: 54%

An evaluation of blood glucose and lipid profile in female hypothyroidism patients in Kerbala province, Iraq

Al-Fatlawi

2022

Biomedicine

View full text Add to dashboard Cite

Introduction and Aim: Hypothyroidism is a common metabolic disorder caused by inadequate secretion of the thyroid hormone by the thyroid glands. The condition impacts various metabolic processes including glucose synthesis, lipid synthesis, mobilization and metabolic rate. This study aimed to evaluate the physiological factors associated with female hypothyroidism patients of Kerbala province of Iraq. Materials and Methods: Fifty females (35 with hypothyroidism and 15 normal) aged between 20-49 years were included in the study. Blood sample was collected from each individual and subjected to thyroid function test (TFT), lipid profile test (LPT) and fasting blood glucose (FBG). Results: The study showed a significant (P?0.001) increase in thyroid stimulating hormone (TSH) levels as compared to control. While a significant decrease was seen in thyroxin (T4) levels in comparison to controls, no significant difference was seen for triiodothyronine (T3) levels in both groups. Low?density lipoprotein (LDL), Triglycerides (TG), total cholesterol (TC) was significantly increased (P?0.001) while high density lipoprotein (HDL) was observed to significantly decrease as compared to control group. High significant elevation (P?0.001) in fasting blood glucose (FBG) was seen in patients with hypothyroidism as compared to control. Conclusion: The results obtained in this study show that hypothyroidism in females to be significantly associated with increase in dyslipidemia and blood glucose levels.

show abstract

“…This may be due to dysfunction of juxta-glomerular and glomerulosa cells respectively. The exaggerated sodium excretion and reduction in potassium excretion could be possibility for the suppression of renin activity and aldosterone in hypothyroid patients [15].…”

Section: Discussionmentioning

confidence: 99%

Study of Serum Electrolytes Imbalances in Female Thyroid Patients at Aiims, Patna: A Hospital Based Comparative Study.

Kumari

Kant

Mahto

2019

IJMBS

View full text Add to dashboard Cite

Objectives: This present study was to compare the serum electrolytes (Na, K and Cl) imbalances in hypothyroidism, hyperthyroidism with euthyroidism female cases. Methods: A detail history, clinical examinations and relevant investigations were performed to all female thyroid cases. Thyroid hormones were estimated by chemiluminiscence method using Siemens Advia Centaur XP instrument. Electrolyte levels (Na+, k+ & Cl-) were measured by ion selective electrode method using Eschweiler combi. Results: Data was analyzed with the help of SPSS (version 26) software. Paired samples statistics was used. Mean ± standard deviation and t value were calculated. P value was taken less than or equal to 0.05 (p ≤ 0.05) for significant differences. Conclusions: This present study concluded that electrolytes sodium, potassium and chloride levels were significantly reduced in hypothyroidism female cases compared to euthyroids female (controls). This suggests that hypothyroid patients should be regularly checked for serum electrolytes. Early detection and treatment can prevent the further complications related to the disorder and will be helpful during the management of thyroid patients. Key words: Hypothyroidism, hyperthyroidism, euthyroidism, electrolytes.

show abstract

A forgotten but important risk factor for severe hyponatremia: myxedema coma

Cited by 8 publications

References 5 publications

Assessment of Serum Minerals and Electrolytes In Thyroid Patients

Assessment of Serum Minerals and Electrolytes In Thyroid Patients

An evaluation of blood glucose and lipid profile in female hypothyroidism patients in Kerbala province, Iraq

Study of Serum Electrolytes Imbalances in Female Thyroid Patients at Aiims, Patna: A Hospital Based Comparative Study.

Contact Info

Product

Resources

About