Squamous Cell Carcinoma and Neuroendocrine Carcinoma Colliding in the Esophagus

Dias, André Roncon; Sallum, Rubens Antônio Aissar; Zalc, Nathalia; Ctenas, Bruno; Ribeiro, Ulysses; Cecconello, Ivan

doi:10.1590/s1807-59322010000100018

Cited by 5 publications

(3 citation statements)

References 11 publications

(8 reference statements)

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“…The World Health Organization classifies all the neuroendocrine neoplasms in three categories, according to their morphology, independently of the primary site; for example, well-differentiated neuroendocrine tumors with low malignant potential, well-differentiated neuroendocrine carcinoma (which are more aggressive with metastatic potential) and poorly-differentiated neuroendocrine carcinomas (which are high grade malignancies with poor prognosis). 7 …”

Section: Discussionmentioning

confidence: 99%

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Small-cell neuroendocrine carcinoma of the esophagus: an autopsy case report

Sepulvida¹,

Amaral²,

Campos³

et al. 2014

ACR

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Small-cell neuroendocrine carcinoma is a well-known aggressive neoplasia, which is usually associated with a poor prognosis. The lung is the most common primary site, but other organs may be involved, especially those of the digestive tract. The authors report the case of a 71-year-old Caucasian, male patient who was admitted because of congestive heart failure and loss of vision accompanied by right proptosis. Skull and sinuses computed tomography showed a tumoral mass involving the posterior region of the right eye, local bones, and paranasal sinuses. Because of severe hemodynamic instability, the patient died and no diagnostic investigation could be performed. Autopsy findings revealed small-cell neuroendocrine carcinoma of the esophagus and metastases to the posterior region of the right ocular globe, which affected the sinuses, the muscles of the ocular region, the orbit bones, the skull, the meninges and the brain, plus the liver, adrenal glands, and the pericardium. This case called the author’s attention to the extent of the metastatic disease in a patient who was firstly interpreted as presenting solely with congestive heart failure. The autopsy findings substantially aid the understanding of the immediate cause of death.

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Section: Discussionmentioning

confidence: 99%

“…Besides environmental factors, genetic alterations have a marked role in the pathophysiology of this tumor,7 independently of the primary site. Among the environmental factors, smoking and alcohol consumption are the main components 2 , 6 , 8.…”

Section: Introductionmentioning

confidence: 99%

Small-cell neuroendocrine carcinoma of the esophagus: an autopsy case report

Sepulvida¹,

Amaral²,

Campos³

et al. 2014

ACR

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“…The first case by Dias et al showed squamous cell and neuroendocrine carcinoma collision. [4] The second case by Wilson et al showed the collision of large-cell neuroendocrine carcinoma with papillary carcinoma arising in Barrett's esophagus. [5] Till now, only seven cases of composite tumor of the esophagus are reported, and out of seven cases, five are in the squamous cell and neuroendocrine carcinoma combination.…”

Section: Concurrent Squamous-cell Carcinoma Esophagus and Atypical Carcinoid Tumor: A Rare Case Report And Review Of Literaturementioning

confidence: 99%