Anti-Arthritic Potential of the Plant Justicia Gendarussa Burm F

Abstract

OBJECTIVE:To evaluate the anti-arthritic potential of the plant Justicia gendarussa using two different rat models. MATERIALS AND METHOD:The anti-arthritic potential of the alcoholic extract of the plant Justicia gendarussa was evaluated using the Freund's adjuvant-induced and collagen-induced arthritic rat models. The rats were treated with the ethanolic extract of Justicia gendarussa and with standard aspirin. RESULTS: The ethanolic extract of Justicia gendarussa showed significant anti-arthritic activity that was statistically similar to that of aspirin. Our results suggest that the alcoholic extract of Justicia gendarussa exhibits significant anti-arthritic potential.

Metabolite Profiling of Justicia gendarussa Burm. f. Leaves Using UPLC-UHR-QTOF-MS

“…f.) can be found wild or cultivated in Indonesia, India, China, Malaysia, Sri Lanka, the Philippines, and Bangladesh. The leaves of this plant have been reported for anti-angiogenic [1], antioxidant [2], antibactericidal [3], antifungal [4], anti-arthritic [5], anti-inflammatory and antinociceptive [6], antisickling [7], anthelmintic [8], cytotoxicity [9], larvicidal, and adulticidal activities [10]. In addition, its aerial parts showed in vitro HIV type 1 reverse transcriptase inhibitor [11], antiinflammatory and analgesic [12], sedative, and hypnotic activities [13].…”

Therapeutic effect of umbelliferon-α-D-glucopyranosyl-(2I→1II)-α-D-glucopyranoside on adjuvant-induced arthritic rats

“…The major reason for the anemia is firstly gastrointestinal blood loss due to the arthritic medication and another bone marrow changes with inflammatory arthritis, which inhibit the incorporation of the iron with the RBC and showed the marked decreased level of the RBC count (Paval et al 2009). Another manifestation in the arthritic condition; marked increased in the level of the WBC was observed due to increase in the level of the IL-1B (Interleukin-1 beta) colony stimulating factor.…”

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“…The arthritis morphological feature of like redness, swelling and erythema 19 , was monitored by set visual criteria as follows: normal paw = 0, mild swelling and erythema of digits = 1, swelling and erythema of the digits = 2, severe swelling and erythema = 3, gross deformity and inability to use the limb = 4 on respective days.…”