Prevalence of Open Angle Glaucoma in Accompanying First Degree Relatives of Patients with Glaucoma

Vegini, Franciele; Filho, Natanael Figueiroa; Lenci, Raphael Furlan; Neto, Diogo Garcia; Susanna, Remo

doi:10.1590/s1807-59322008000300007

Cited by 18 publications

(20 citation statements)

References 15 publications

(17 reference statements)

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“…Therefore, we saw a great opportunity amongst those who accompanied their glaucoma patient relatives to the Glaucoma clinic to carry out this study. The identified prevalence of 18.9% of primary open angle glaucoma amongst the first-degree relatives of patients with primary open-angle glaucoma found in this study is similar to that reported by Vegini et al (20) (16.8%). The Vegini's study also screened those who accompanied their glaucoma patients to a referral tertiary health facility.…”

Section: Discussionsupporting

confidence: 91%

“…It is, however, higher than 13.3% that was found in another study in India (5) . In our study, the prevalence of glaucoma was higher amongst offspring (13.7%) compare to siblings (5.2%) as also reported by Vegini et al (20) . However, both the American and Indian studies (5,14) reported higher prevalence amongst siblings than offspring.…”

Section: Discussionsupporting

confidence: 89%

“…The Baltimore Eye Survey (9) found that the relative risk of having glaucoma is increased 3.7-fold for individual who have a sibling with primary open-angle glaucoma compared to an individual who has a parent with primary open angle glaucoma that has a 2.2-fold risk of developing glaucoma. It is obvious from our study like the other studies (5,14,20) that the prevalence of primary open-angle glaucoma is higher amongst first degree relatives than the general populations (2,4,7,8,10) . Therefore, every effort should be directed at getting this high-risk population screened for the disease.…”

Section: Discussionsupporting

confidence: 75%

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Opportunistic Screening for Glaucoma Amongst Glaucoma Patients’ First Degree Relatives who Accompanied them to Glaucoma Clinic

Nathaniel

Awoyesuku²

2017

IAM

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Aim: To identify people with glaucoma and glaucoma suspect amongst first degree relatives accompanying their glaucoma patient relatives to the Glaucoma clinic, University of Port Harcourt Teaching Hospital, Port Harcourt. Materials and methods: It was a prospective population-based study of first-degree relatives of Primary open-angle glaucoma patients who accompanied them to the glaucoma clinic. All participating individuals underwent comprehensive eye examination including vision screening, refraction, slit lamp biomicroscopy, applanation tonometry, gonioscopy and dilated fundus examination. Persons with definite and suspected glaucoma were subjected to threshold standard automated perimetry. Results: A total of 95 individuals who were first-degree relatives of 41 patients with Primary open angle glaucoma were examined. Fifty-seven of them (60%) were males, and 38 (40%) were females, with a mean age of 37.71± 8.15 years. Eighty-three (87.37%) were offspring and 12 (12.63%) siblings. Eighteen (18.9%) were observed to have definite Primary open angle glaucoma; 7 (7.4%) of them had been previously diagnosed. Another 16 (16.8%) of the relatives were found to be Glaucoma suspect. Twelve (66.7%) of those with glaucoma were males while 6 (33.3%) were females;13 (72.2%) were offspring while 5 (27.8%) were siblings.Prevalence of primary open angle glaucoma was 13.7% for offspring and 5.3% for siblings. Conclusion: Prevalence of primary open angle glaucoma amongst first degree relatives of glaucoma patients is higher than the general population. Targeted screening of at-risk group will help in early detection and treatment.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 75%

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Opportunistic Screening for Glaucoma Amongst Glaucoma Patients’ First Degree Relatives who Accompanied them to Glaucoma Clinic

Nathaniel

Awoyesuku²

2017

IAM

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“…Entretanto, apesar de várias entidades promoverem a iniciativa de programas de triagem em massa, um protocolo eficiente e custo-efetivo ainda não está disponível (8) . Uma possível estratégia para aumentar a efetividade de protocolos de triagem seria focar em populações de risco, dentre as quais as de raça negra, com pressão intraocular acima dos níveis estatisticamente aceitos e parentes de glaucomatosos.…”

Section: Discussionunclassified

Morfometria comparativa entre discos ópticos de familiares de glaucomatosos e normais pelo HRTII

Costa¹,

Gonçalves²,

Almeida³

et al. 2012

Rev. bras.oftalmol.

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RESUMOObjetivo: Comparar discos ópticos de pacientes normais com história familiar de glaucoma primário de ângulo aberto (GPAA) com um grupo controle sem histórico familiar de glaucoma através da oftalmoscopia confocal a laser (HRTII). Métodos: Análise retrospectiva da morfometria dos discos ópticos de pacientes com e sem história familiar de GPAA. Cada paciente foi submetido a exame oftalmológico completo, perimetria computadorizada, paquimetria e HRTII. Os pacientes foram classificados em três grupos de acordo com o grau de parentesco: primeiro grau (grupo 1), segundo grau (grupo 2) e grupo controle sem história familiar de glaucoma (grupo 3). Foram analisados: área total do disco óptico (Área Total), área de faixa neural (FxN), área da escavação (Esc.), relação escavação/disco (E/D) e relação E/D linear (L). Para a análise estatística, utilizou-se o programa SPSS 12.0. considerando-se apenas um dos olhos de cada paciente selecionado aleatoriamente. Resultados: Foram incluídos setenta e quatro pacientes com idade média de 42,58 anos. Comparando-se os grupos 1 e 2, encontrou-se diferença estatisticamente significativa na variável Área Total, observando-se discos ópticos maiores no grupo 1. Comparando-se os grupos 1 e 3, as diferenças entre as variáveis Área Total, Esc, E/D e L foram estatisticamente significativas com predominância de valores mais elevados no grupo 1. Comparando-se os dados estereométricos entre os grupos 2 e 3 não foram encontradas diferenças de valores estatisticamente significantes. Conclusão: Pacientes normais parentes de primeiro grau de glaucomatosos apresentam maiores valores das variáveis topográficas do disco óptico quando comparados aos dos pacientes sem histórico familiar de glaucoma.

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“…These patients suffer from high IOP. Besides high IOP, family history is considered a risk factor for POAG, with a relative risk of 9.2 in populations with positive family histories (21). Finding out the relative risk could be very valuable in predicting the status of the disease in a population.…”

Section: Primary Open Angle Glaucomamentioning

confidence: 99%

Gene-Finding Strategy in Glaucoma

Narooie‐Nejad

2018

Gene Cell Tissue

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Glaucoma is a group of complex eye disorders characterized by increased intraocular pressure, optic nerve damage, and ultimately, optic nerve cupping, ending in irreversible blindness. The age of onset and the anatomy of the anterior chamber indicate that glaucoma consists of the categories of primary open-angle glaucoma, primary congenital glaucoma, and primary angle closure glaucoma. To date, many loci have shown to be associated with different types of glaucoma; however, the underlying cause of the disease remains ambiguous. Two main approaches exist to find new loci and genes associated with the disease: linkage analysis, which is applicable for large pedigrees with multiple affected and healthy individuals, and a genome-wide association study for large cohorts of sporadic cases. Careful patient selection is the first step in these kinds of genetic research. All subjects selected should be examined to identify the known gene mutations for the specific type of glaucoma. Subjects with no mutations in known genes are possible subjects of a genome-wide association study or linkage analysis.

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Prevalence of Open Angle Glaucoma in Accompanying First Degree Relatives of Patients with Glaucoma

Cited by 18 publications

References 15 publications

Opportunistic Screening for Glaucoma Amongst Glaucoma Patients’ First Degree Relatives who Accompanied them to Glaucoma Clinic

Opportunistic Screening for Glaucoma Amongst Glaucoma Patients’ First Degree Relatives who Accompanied them to Glaucoma Clinic

Morfometria comparativa entre discos ópticos de familiares de glaucomatosos e normais pelo HRTII

Gene-Finding Strategy in Glaucoma

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