Occurrence of Early Adverse Events After Vaccination Against Influenza at a Brazilian Reference Center

Lopes, Marta Heloísa; Mascheretti, Melissa; Franco, Marília Miranda; Vasconcelos, Ricardo; Gutierrez, Eliana Battaggia

doi:10.1590/s1807-59322008000100005

Cited by 10 publications

(7 citation statements)

References 13 publications

(9 reference statements)

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“…As HCWs are aware of vaccine adverse events and fear its consequences, it is comprehensible that these events will be more frequently reported by them than by general population. Another study conducted in the same hospital demonstrated that HCWs reported significantly more adverse events (52.9%) than the elderly (25.3%) [20]. The higher frequency of adverse events reported by HCWs surveyed in the first five days of vaccination, as compared with those surveyed after the fifth day, may suggest that people may be more predisposed to remember any symptom possibly associated with the vaccine if inquired within the first days of vaccination.…”

Section: Discussionmentioning

confidence: 97%

Fighting Misconceptions to Improve Compliance with Influenza Vaccination among Health Care Workers: An Educational Project

et al. 2012

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The compliance with influenza vaccination is poor among health care workers (HCWs) due to misconceptions about safety and effectiveness of influenza vaccine. We proposed an educational prospective study to demonstrate to HCWs that influenza vaccine is safe and that other respiratory viruses (RV) are the cause of respiratory symptoms in the months following influenza vaccination. 398 HCWs were surveyed for adverse events (AE) occurring within 48 h of vaccination. AE were reported by 30% of the HCWs. No severe AE was observed. A subset of 337 HCWs was followed up during four months, twice a week, for the detection of respiratory symptoms. RV was diagnosed by direct immunofluorescent assay (DFA) and real time PCR in symptomatic HCWs. Influenza A was detected in five episodes of respiratory symptoms (5.3%) and other RV in 26 (27.9%) episodes. The incidence density of influenza and other RV was 4.3 and 10.8 episodes per 100 HCW-month, respectively. The educational nature of the present study may persuade HCWs to develop a more positive attitude to influenza vaccination.

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Section: Discussionmentioning

confidence: 97%

Fighting Misconceptions to Improve Compliance with Influenza Vaccination among Health Care Workers: An Educational Project

et al. 2012

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“…The initial proposal for all CRIE was that they were privileged spaces for the development of teaching and research, training and capacity building. Some CRIE have developed studies in specific populations immunizations and adverse events following immunizaiton 3 , 6 , 10 - 12 , 17 , 18 , 20 - 23 . The CRIE that comprise the two most well-structured profiles could further develop teaching and research activities, counting on greater support and encouragement of the SES and the Ministry of Health/PNI.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Reference Centers for Special Immunobiologicals implementation

2016

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OBJECTIVE To describe the Reference Centers for Special Immunobiologicals and evaluate their implementation considering formal regulations.METHODS We conducted a program evaluation, of evaluative research type. From August 2011 to January 2012, a questionnaire was applied to the 42 Reference Centers for Special Immunobiologicals existing in the Country, approaching the structure, human resources, and developed activities dimensions. We conducted a descriptive analysis of data and used a clustering for binary data with the squared Euclidean distance, by the farthest neighbor method, to aggregate services with similar features.RESULTS We observed great diversity among the services in the three dimensions. The clustering resulted in five service profiles, named according to their characteristics. 1) Best structure: 12 Reference Centers for Special Immunobiologicals with the highest proportion of services with the minimum of rooms recommended, purpose-built vaccine refrigerators, preventive maintenance of the cold chain, and oxygen source. 2) Immunobiologicals distributor: six Reference Centers for Special Immunobiologicals that distributed more than applied immunogens; no doctor present for more than half of the working hours and no purpose-built vaccine refrigerators . 3) Incipient implementation: five Reference Centers for Special Immunobiologicals with inadequate structure, such as absence of purpose-built vaccine refrigerators, preventive maintenance of the cold chain and oxygen source; none had computer. 4) Vaccination rooms: 13 Reference Centers for Special Immunobiologicals, everyone did routine immunization, most participated in vaccination campaigns. 5) Teaching and research: six services, all inserted into teaching hospitals, developed researches and received trainees; most had doctors in more than half of the working hours.CONCLUSIONS The evaluation of the Reference Centers for Special Immunobiologicals implementation was based on the profiles found and considered the official regulations: services categorized as “better structure” and “teaching and research” were considered implemented; “immunobiologicals distributor” and “vaccination room” services, partially implemented, and the ones with the “incipient implementation” profile, not implemented. The results of this evaluation can contribute to the reformulation of the services, considering the current context.

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“…Ensaios clínicos, com a participação de crianças, realizados para estimar a eficácia e a segurança das vacinas contra a influenza A (H1N1) 2009 e as notificações recebidas de países que realizaram a vacinação antes do Brasil, indicaram que esses imunobiológicos eram tão seguros quanto os da influenza sazonal 11,12,13,14 . Entretanto, estudos sobre os eventos adversos pós-vacinação contra a influenza ainda são escassos no Brasil, principalmente, os que incluem crianças, uma vez que estas somente receberem a vacina anual do sistema público de saúde se pertencerem aos grupos de risco para complicações da doença 15,16 .…”

Section: Eventos Adversos Pós-vacinação Contra Infl Uenza Pandêmica Aunclassified

Eventos adversos pós-vacinação contra influenza pandêmica A (H1N1) 2009 em crianças

et al. 2012

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The aim of this study was to estimate the frequency of adverse events following vaccination against pandemic influenza A (H1N1) 2009 and associated factors in children from six months to two years of age (n = 156). Multivariate Cox regression was used to assess the independent associations between covariates and complaints of at least one adverse event. Strength of association was measured by hazard ratios and respective 95% confidence intervals. Following the first dose, 40.3% of parents reported one or more adverse events in their children, compared to 35.5% after the second dose. Systemic adverse events, specifically irritation, diarrhea, and fever, were more frequent than local reactions at the vaccination site. Incidence rates for adverse events in general and systemic reactions following the first dose were higher in children with concomitant illness or allergies (HR = 3.43, 95%CI: 1.34-8.77 and HR = 2.76, 95%CI: 1.11-6.89). Most events were mild. Cases of high fever, vomiting, and diarrhea prompted parents to seek care for their children at health services.

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Occurrence of Early Adverse Events After Vaccination Against Influenza at a Brazilian Reference Center

Cited by 10 publications

References 13 publications

Fighting Misconceptions to Improve Compliance with Influenza Vaccination among Health Care Workers: An Educational Project

Fighting Misconceptions to Improve Compliance with Influenza Vaccination among Health Care Workers: An Educational Project

Evaluation of Reference Centers for Special Immunobiologicals implementation

Eventos adversos pós-vacinação contra influenza pandêmica A (H1N1) 2009 em crianças

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