Nonoperative Management of Infected Pancreatic Necrosis

Pancreatitis Associated with Olsalazine and Sulfasalazine in Children with Ulcerative Colitis

“…The pancreatitis was associated with flares of disease activity manifested by bloody diarrhea in all three patients. The same association has occurred in about one third of the other amino salicylateassociated episodes of pancreatitis reported, with 25% clearly not associated with inflammatory bowel disease flares and the rest ambiguous (16)(17)(18)(19)(20)(21)(22). It is therefore unlikely that the colitis disease flare played a role in the pancreatitis in our patients, except by stimulating the use of medication.…”

“…Since pancreatitis frequently has been associated with the use of pharmacotherapeutic agents such as 6-mercaptopurine (23)(24)(25), azathioprine (26), corticosteroids (27), and sulfasalazine (16,17), this complication has also been blamed on these agents. In particular, acute pancreatitis described in patients treated with sulfasalazine has been attributed to the sulfapyridine portion of the drug.…”

“…Among the adverse effects reported with sulfasalazine is pancreatitis (16,17). To our knowledge, there has been only one case report of pancreatitis in a patient on olsalazine and that was in an adult with Crohn' s disease, which itself has been linked with pancreatitis (18).…”

Idiopathic Pancreatitis Preceding the Diagnosis of Inflammatory Bowel Disease Is More Frequent in Pediatric Patients

“…Moreover, pancreatic histological changes have been documented in 38% to 53% of postmortem pathological examinations (7)(8)(9)(10)(11)(12). Pancreatitis associated with IBD has mostly been thought to be caused by drugs used to treat IBD (4,13,14), biliary lithiasis (15), duodenal involvement of Crohn disease (CD) (16,17), or sclerosing cholangitis (18). There are only a few case reports, mainly in adults (6,19), describing AP as the first presenting clinical feature of IBD.…”