Measurement of S-100b for Risk Classification of Victims Sustaining Minor Head Injury - First Pilot Study in Brazil

Poli-de-Figueiredo, Luiz Francisco; Biberthaler, Peter; Filho, Charles Simão; Hauser, Christopher; Mutschler, Wolf; Jochum, Marianne

doi:10.1590/s1807-59322006000100008

Cited by 44 publications

(41 citation statements)

References 25 publications

(37 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The design and patient characteristics of the 12 studies 98,113,115,130,[143][144][145][146][147][148][149][150] that evaluated the diagnostic accuracy of various biochemical markers for diagnosing ICI (including the need for neurosurgery) in adults and children with MHI are summarised in Table 18. Nine studies provided diagnostic data on protein S100B only, 98,113,115,[143][144][145][146][147][148][149] one on NSE only 115,130 and one on other markers [creatine kinase isozyme (CK-BB), noradrenaline, adrenaline, dopamine, amylase and total catecholamines].…”

Section: Description Of Included Studies (Design and Patient Charactementioning

confidence: 99%

“…Nine studies provided diagnostic data on protein S100B only, 98,113,115,[143][144][145][146][147][148][149] one on NSE only 115,130 and one on other markers [creatine kinase isozyme (CK-BB), noradrenaline, adrenaline, dopamine, amylase and total catecholamines]. 150 One study 115 provided diagnostic data on both protein S100B and NSE levels.…”

Section: Description Of Included Studies (Design and Patient Charactementioning

confidence: 99%

See 1 more Smart Citation

Diagnostic management strategies for adults and children with minor head injury: a systematic review and an economic evaluation

Pandor

Goodacre²,

Harnan³

et al. 2011

Health Technol Assess

108

114

View full text Add to dashboard Cite

How to obtain copies of this and other HTA programme reports An electronic version of this title, in Adobe Acrobat format, is available for downloading free of charge for personal use from the HTA website (www.hta.ac.uk). A fully searchable DVD is also available (see below).Printed copies of HTA journal series issues cost £20 each (post and packing free in the UK) to both public and private sector purchasers from our despatch agents.Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per issue and for the rest of the world £3 per issue. How to order:-fax (with credit card details) -post (with credit card details or cheque) -phone during office hours (credit card only).Additionally the HTA website allows you to either print out your order or download a blank order form. Contact details are as follows:Synergie UK (HTA Department) Digital House, The Loddon Centre Wade Road Basingstoke Hants RG24 8QW Email: orders@hta.ac.uk Tel: 0845 812 4000 -ask for 'HTA Payment Services' (out-of-hours answer-phone service) Fax: 0845 812 4001 -put 'HTA Order' on the fax header Payment methods Paying by chequeIf you pay by cheque, the cheque must be in pounds sterling, made payable to University of Southampton and drawn on a bank with a UK address.Paying by credit card You can order using your credit card by phone, fax or post. SubscriptionsNHS libraries can subscribe free of charge. Public libraries can subscribe at a reduced cost of £100 for each volume (normally comprising 40-50 titles). The commercial subscription rate is £400 per volume (addresses within the UK) and £600 per volume (addresses outside the UK). Please see our website for details. Subscriptions can be purchased only for the current or forthcoming volume.How do I get a copy of HTA on DVD?Please use the form on the HTA website (www.hta.ac.uk/htacd/index.shtml). HTA on DVD is currently free of charge worldwide.The website also provides information about the HTA programme and lists the membership of the various committees. HTADiagnostic management strategies for adults and children with minor head injury: a systematic review and an economic evaluation NIHR Health Technology Assessment programmeThe Health Technology Assessment (HTA) programme, part of the National Institute for Health Research (NIHR), was set up in 1993. It produces high-quality research information on the effectiveness, costs and broader impact of health technologies for those who use, manage and provide care in the NHS. 'Health technologies' are broadly defined as all interventions used to promote health, prevent and treat disease, and improve rehabilitation and long-term care. The research findings from the HTA programme directly influence decision-making bodies such as the National Institute for Health and Clinical Excellence (NICE) and the National Screening Committee (NSC). HTA findings also help to improve the quality of clinical practice in the NHS indirectly in that they form a key component of the 'National Knowledge Service' . The HTA...

show abstract

Section: Description Of Included Studies (Design and Patient Charactementioning

confidence: 99%

Section: Description Of Included Studies (Design and Patient Charactementioning

confidence: 99%

Diagnostic management strategies for adults and children with minor head injury: a systematic review and an economic evaluation

Pandor

Goodacre²,

Harnan³

et al. 2011

Health Technol Assess

108

114

View full text Add to dashboard Cite

show abstract

“…Most of these studies have been conducted in adult and paediatric patients who had suffered head trauma of varying degrees. [4][5][6][7][8][9] Other studies ABSTRACT: Background: It has been shown previously that S-100β levels in serum correspond with the severity of central nervous system (CNS) trauma. It also has been suggested that S-100β in CNS tissue is involved in neuroprotection and neuroregeneration.…”

mentioning

confidence: 99%

Quercetin Administration After Spinal Cord Trauma Changes S-100β Levels

Schültke

Griebel²,

Juurlink³

2010

Can. j. neurol. sci.

View full text Add to dashboard Cite

S-100β, a small monomer of the calcium-binding S-100 protein family with a molecular weight of about 10 kDa, has been found in both astrocytes and oligodendrocytes.1 Being present throughout the cytosol and as components of cytoskeleton and membranes; it has been suggested that S-100β is involved in guiding the progression of cells through the cell cycle.2 With a little over one and a half hours, S-100β has a relatively short half life, which makes it a good candidate for assessment in emergency situations like central nervous system (CNS) trauma. 3 The results of studies conducted by a number of authors have shown that serum levels of S-100β can be used as predictor for the extent of tissue injury in the CNS. Most of these studies have been conducted in adult and paediatric patients who had suffered head trauma of varying degrees. [4][5][6][7][8][9] Other studies ABSTRACT: Background: It has been shown previously that S-100β levels in serum correspond with the severity of central nervous system (CNS) trauma. It also has been suggested that S-100β in CNS tissue is involved in neuroprotection and neuroregeneration. We have previously shown that administration of quercetin results in improved motor function in an animal model of spinal cord trauma. Methods: Mid-thoracic spinal cord compression injury was produced in adult male Wistar rats. Serum and tissue samples were acquired from quercetin-treated animals (25 µmol / kg) and saline controls at 6, 12 and 24 hours after the trauma. S-100β levels were measured using a luminometric assay in the damaged tissue and in the serum of the animals. Results: The increase in serum S-100β levels seen in saline controls after spinal cord trauma was ameliorated in the quercetin-treated animals at all time points, although the difference to saline controls became statistically significant only at 24 hrs after the trauma. Compared to tissue S-100β levels in healthy animals, values were significantly decreased in saline controls at all three time points, while they were decreased at 6 hrs and increased at both 12 and 24 hrs in quercetin-treated animals. At all three time points tissue S-100β levels were significantly higher in quercetin-treated animals than in saline controls. Conclusions: Administration of quercetin results in modification of S-100β levels in the setting of experimental spinal cord trauma. The kinetic patterns of the S-100β fluctuations in serum and tissue suggest that post-traumatic administration of quercetin decreases the extent of CNS injury.RÉSUMÉ: L'administration de quercétine après un traumatisme à la moelle épinière modifie les niveaux de S-100β. Contexte : Des travaux antérieurs ont démontré que les niveaux de S-100β du sérum correspondent à la sévérité du traumatisme au niveau du système nerveux central (SNC) et il est possible que le S-100β joue un rôle dans la neuroprotection et la neurorégénération du SNC. Nous avons démontré antérieurement que l'administration de quercétine améliore la fonction motrice chez un modèle animal de traumatisme de la moe...

show abstract

“…Previous studies identified maximum sensitivity for abnormal head CT at an S100B level of 0.10-0.12 lg/L. 9,10,[25][26][27][28][29] In our cohort, the 98% sensitivity level was not reached until the S100B level was below 0.060 lg/L. At a cutoff of 0.10 lg/L, the FIG.…”

Section: Discussionmentioning

confidence: 68%

Classification Accuracy of Serum Apo A-I and S100B for the Diagnosis of Mild Traumatic Brain Injury and Prediction of Abnormal Initial Head Computed Tomography Scan

Bazarian

Blyth

et al. 2013

Journal of Neurotrauma

View full text Add to dashboard Cite

The objective of the current study was to determine the classification accuracy of serum S100B and apolipoprotein (apoA-I) for mild traumatic brain injury (mTBI) and abnormal initial head computed tomography (CT) scan, and to identify ethnic, racial, age, and sex variation in classification accuracy. We performed a prospective, multi-centered study of 787 patients with mTBI who presented to the emergency department within 6 h of injury and 467 controls who presented to the outpatient laboratory for routine blood work. Serum was analyzed for S100B and apoA-I. The outcomes were disease status (mTBI or control) and initial head CT scan. At cutoff values defined by 90% of controls, the specificity for mTBI using S100B (0.899 [95% confidence interval (CI): 0.78-0.92]) was similar to that using apoA-I (0.902 [0.87-0.93]), and the sensitivity using S100B (0.252 [0.22-0.28]) was similar to that using apoA-I (0.249 [0.22-0.28]). The area under the receiver operating characteristic curve (AUC) for the combination of S100B and apoA-I (0.738, 95% CI: 0.71, 0.77), however, was significantly higher than the AUC for S100B alone (0.709, 95% CI: 0.68, 0.74, p = 0.001) and higher than the AUC for apoA-I alone (0.645, 95% CI: 0.61, 0.68, p < 0.0001). The AUC for prediction of abnormal initial head CT scan using S100B was 0.694 (95%CI: 0.62, 0.77) and not significant for apoA-I. At a S100B cutoff of < 0.060 lg/L, the sensitivity for abnormal head CT was 98%, and 22.9% of CT scans could have been avoided. There was significant age and race-related variation in the accuracy of S100B for the diagnosis of mTBI. The combined use of serum S100B and apoA-I maximizes classification accuracy for mTBI, but only S100B is needed to classify abnormal head CT scan. Because of significant subgroup variation in classification accuracy, age and race need to be considered when using S100B to classify subjects for mTBI.

show abstract

Measurement of S-100b for Risk Classification of Victims Sustaining Minor Head Injury - First Pilot Study in Brazil

Cited by 44 publications

References 25 publications

Diagnostic management strategies for adults and children with minor head injury: a systematic review and an economic evaluation

Diagnostic management strategies for adults and children with minor head injury: a systematic review and an economic evaluation

Quercetin Administration After Spinal Cord Trauma Changes S-100β Levels

Classification Accuracy of Serum Apo A-I and S100B for the Diagnosis of Mild Traumatic Brain Injury and Prediction of Abnormal Initial Head Computed Tomography Scan

Contact Info

Product

Resources

About