Conservative Treatment of Pancreatic Necrosis With Suggestive Signs of Infection

Amico, Ênio Campos; Canedo, Leonardo Fernandes; Machado, Cibele Chuery; Faria, Suzanna Gondim; Vivas, Danilo Vendrame

doi:10.1590/s1807-59322005000500012

Cited by 5 publications

(2 citation statements)

References 19 publications

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“…The standard treatment of AP is still based on supportive care 26 . The search for new drugs that could alter the natural history of the disease is a continuing challenge for many researchers.…”

Section: Discussionmentioning

confidence: 99%

Inhibition of Cyclooxygenase-2 in Experimental Severe Acute Pancreatitis

Almeida

Jukemura

Coelho

et al. 2006

Clinics

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BACKGROUND:The standard treatment for acute pancreatitis (AP) is still based on supportive care. The search for a new drug that could change the natural history of the disease is a continuing challenge for many researchers. The aim of this study is to evaluate the effect of a cyclooxygenase-2 (COX-2) inhibitor on experimental AP in rats. METHODS:The animals were divided into 2 groups: Group 1 (n = 30)-animals with taurocholate-induced AP treated with parecoxib (40 mg/kg). Group 2 (n = 30)-animals with taurocholate-induced AP that received saline. The COX-2 inhibitor (parecoxib) was injected immediately after AP induction, through the penis dorsal vein. The parameters evaluated were histology, serum levels of amylase, IL-6 and IL-10, and mortality rate. RESULTS: The serum levels of IL-6 and IL-10 in the parecoxibtreated group were lower than the control group. The amylase serum levels and the mortality rate remained unchanged in the treated animals. Histologic morphology also was unaltered, except for fat necrosis, which was higher in parecoxib-treated rats. CONCLUSION: Inhibition of Cox-2 decreases the systemic release of inflammatory cytokines, but has a poor effect on the direct pancreas injury caused by taurocholate.

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Section: Discussionmentioning

confidence: 99%

Inhibition of Cyclooxygenase-2 in Experimental Severe Acute Pancreatitis

Almeida

Jukemura

Coelho

et al. 2006

Clinics

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show abstract

“…Exclusive antibiotic therapy, as recently discussed by Amico et al, 6 has been advocated by some, but it is unlikely to become a first-line option unless new drugs or prescription protocols that are particularly effective for such complex and dangerous intraperitoneal and retroperitoneal infected lesions are developed. Patients in good clinical condition tend to have the best results, according to preliminary findings as well as to our own experience; 1 however, these are also the subjects with favorable outcomes in face of any therapeutic modality.…”

Section: Editorialmentioning

confidence: 99%