Evaluation of Blood Transfusion Effects on Mixed Venous Oxygen Saturation and Lactate Levels in Patients With Sirs/Sepsis

Mazza, Bruno Franco; Machado, Flávia Ribeiro; Mazza, Débora Dutra da Silveira; Hassmann, Valeria

doi:10.1590/s1807-59322005000400009

Cited by 36 publications

(21 citation statements)

References 26 publications

(21 reference statements)

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“…44,45 In the present study, the sensitivity of lactate in response to the impact of rapid blood transfusion in the LP group was superior to that of base deficit. Patients who received 0.9% normal saline showed reduced lactate levels compared with the LP group.…”

Section: Hs Chung Sj Cho Cs Park Rapid Blood Transfusion-induced Iocontrasting

confidence: 43%

Effects of Liver Function on Ionized Hypocalcaemia following Rapid Blood Transfusion

Chung

Cho

2012

J Int Med Res

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Section: Hs Chung Sj Cho Cs Park Rapid Blood Transfusion-induced Iocontrasting

confidence: 43%

Effects of Liver Function on Ionized Hypocalcaemia following Rapid Blood Transfusion

Chung

Cho

2012

J Int Med Res

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“…Another study evaluated the effects of RBC transfusion in patients with SIRS or sepsis who presented with Hb of Ͻ9 g/dL at ICU admission (134). Hb levels, mixed venous oxygen saturation, and lactate levels were collected before RBC transfusion and up to 1 hr after transfusion.…”

Section: B Recommendations Regarding Rbc Transfusion In Sepsismentioning

confidence: 99%

Clinical practice guideline: Red blood cell transfusion in adult trauma and critical care*

Napolitano

Kurek

Luchette

et al. 2009

Critical Care Medicine

442

222

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“…7 This finding contrasted with other clinical studies in which hemodynamic optimization was not clearly effective. 8,9 In early goal-directed therapy, the precocious match between oxygen consumption and delivery is achieved with central venous oxygen saturation (ScvO 2 ) ≥ 70%. This approach has been respon-sible for significant reductions in in-hospital mortality.…”

Section: Introductionmentioning

confidence: 99%

Evolutive Standard Base Excess and Serum Lactate Level in Severe Sepsis and Septic Shock Patients Resuscitated With Early Goal-Directed Therapy: Still Outcome Markers?

Park

Azevedo

Maciel

et al. 2006

Clinics

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Park M, Azevedo LCP, Maciel AT, Pizzo VR, Noritomi DT, Cruz Neto LM da. Evolutive Standard base excess and serum lactate level in Severe sepsis and septic shock patients resuscitated with early goal-directed therapy: still outcome markers? Clinics. 2006;61(1):47-52. PURPOSE:To compare the evolution of standard base excess and serum lactate level between surviving and non surviving patients with severe sepsis and septic shock resuscitated with early goal-directed therapy. METHODS: This is a retrospective study in an intensive care unit of a university tertiary hospital where 65 consecutive severe sepsis and septic shock patients were observed without any intervention in the treatment by the authors of this report. RESULTS: In our study, the mortality of severe sepsis and septic shock patients was 38%. The central venous oxygen saturation of both groups was above 70% after the resuscitative period, excluding the second day of the non survivors group (69.8%). After the second day, the central venous oxygen saturation was significantly higher in the survivors group (P < .001). Standard base excess was initially low in both groups, but from the second day on, the correction of standard base excess was significantly more successful and linear in the survivor group (P < .001). Lactate levels were similar during the evolution of both groups. CONCLUSIONS: Although evolutive standard base excess and serum lactate level are still outcome markers in severe sepsis and septic shock patients resuscitated with early goal-directed therapy, other studies must be performed to clarify if hemodynamic interventions based on standard base excess and serum lactate level could be reliable to improve clinical outcomes in severe sepsis and septic shock patients

show abstract

Evaluation of Blood Transfusion Effects on Mixed Venous Oxygen Saturation and Lactate Levels in Patients With Sirs/Sepsis

Cited by 36 publications

References 26 publications

Effects of Liver Function on Ionized Hypocalcaemia following Rapid Blood Transfusion

Effects of Liver Function on Ionized Hypocalcaemia following Rapid Blood Transfusion

Clinical practice guideline: Red blood cell transfusion in adult trauma and critical care*

Evolutive Standard Base Excess and Serum Lactate Level in Severe Sepsis and Septic Shock Patients Resuscitated With Early Goal-Directed Therapy: Still Outcome Markers?

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