Adiponectin and interleukin-6 levels in insulin-treated diabetic rats with experimental periodontitis

Xynogala, Ioanna; Pepelassi, Eudoxie; Perrea, Despina; Agrogiannis, George; Pantopoulou, Alkistis; Patsouris, Efstratios; Vrotsos, Ioannis

doi:10.1590/s1806-83242012000100012

Cited by 5 publications

(7 citation statements)

References 33 publications

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“…187 The mechanisms by which periodontitis affects diabetes are not entirely clear but include increased circulating levels of different cytokines, such as interleukin-1-beta, tumor necrosis factor-alpha, and adiponectin, as well as increased adipose tissue inflammation. 184,185,188 Taken together, animal studies also point to the bidirectional role of diabetes and periodontitis and shed some light on the mechanism by which these conditions lead to a pro-inflammatory response.…”

Section: Lessons From Animal Models: Interactions Between Diabetes and Periodontitismentioning

confidence: 96%

“…Periodontitis even alters glucose metabolism in rodents with prediabetes 187 . The mechanisms by which periodontitis affects diabetes are not entirely clear but include increased circulating levels of different cytokines, such as interleukin‐1‐beta, tumor necrosis factor‐alpha, and adiponectin, as well as increased adipose tissue inflammation 184,185,188 …”

Section: Diabetesmentioning

confidence: 99%

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Association between metabolic syndrome and periodontitis: The role of lipids, inflammatory cytokines, altered host response, and the microbiome

Pirih

Monajemzadeh

Singh

et al. 2021

Periodontology 2000

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Periodontitis is a "chronic inflammatory disease associated with dysbiotic plaque biofilms and characterized by a progressive destruction of the tooth supporting apparatus". 1 Periodontitis affects 42.2% of the US population aged older than 30 years and 59.8% of those aged older than 65 years. 2 According to the World Health Organization, periodontitis is the major cause of tooth loss in adults. 3 Periodontitis pathogenesis is multifactorial with environmental, microbial, and host involvement affecting disease outcomes. Many systemic conditions have been associated with periodontitis, including diabetes mellitus, cardiovascular disease, and metabolic syndrome. [4][5][6][7][8][9][10][11] Metabolic syndrome is a cluster of conditions that occur concomitantly and together they increase the risk of cardiovascular disease and double the risk of type 2 diabetes. [12][13][14][15] Metabolic syndrome affects approximately 34% of the US population 16 and 10% of US adolescents. 17 The prevalence of metabolic syndrome also increases with age and varies with ethnicity and gender. 18 Several definitions of metabolic syndrome exist and differ slightly depending on the issuing agency. The most commonly utilized definition is provided by the National Cholesterol Education Program Adult Treatment Panel III. This definition requires that the individual has at least three of the following risk factors: (a) increased abdominal circumference, (b) low plasma levels of high-density lipoprotein cholesterol, (c) increased values for plasma triglycerides, (d) elevated blood pressure, and (e) elevated glucose levels. 19 Prediabetes is also accepted as part of metabolic syndrome because it is associated with insulin resistance and is highly predictive of new-onset type 2 diabetes. 20The predominant underlying risk factors for metabolic syndrome appear to be abdominal obesity and insulin resistance. Other associated conditions are physical inactivity, aging, and hormonal imbalance. 21 Among the risk factors, visceral adiposity appears to be aThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Section: Lessons From Animal Models: Interactions Between Diabetes and Periodontitismentioning

confidence: 96%

Section: Diabetesmentioning

confidence: 99%

Association between metabolic syndrome and periodontitis: The role of lipids, inflammatory cytokines, altered host response, and the microbiome

Pirih

Monajemzadeh

Singh

et al. 2021

Periodontology 2000

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“…Adiponectin can reduce insulin resistance and enhance the action of insulin in the liver, resulting in a reduction of blood glucose levels . In a recent study, a statistically significant increase in levels of adiponectin was observed in diabetic rats with experimental periodontitis …”

Section: Diabetes As a Risk And Modifying Factor For Periodontitismentioning

confidence: 98%

“…41,42 In a recent study, a statistically significant increase in levels of adiponectin was observed in diabetic rats with experimental periodontitis. 43 Leptin is produced by the ob (obese) gene in adipose tissue cells, especially in white adipose tissue, its action is on the hypothalamus resulting in decreased food intake and increased energy consumption. 44,45 Leptin increases insulin sensitivity by influencing insulin secretion, glucose utilisation, glycogen synthesis and fatty acid metabolism.…”

Section: How Diabetes Affects Periodontal Health Adipokines and Inflamentioning

confidence: 99%

Periodontitis and type II diabetes: a two-way relationship

Chee

Park

Bartold

2013

International Journal of Evidence-Based Healthcare

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For many years an association between diabetes and periodontitis has been suspected. In more recent times this relationship has been suggested to be bidirectional with each condition being able to influence the other. In this review the two-way relationship between diabetes and periodontitis is considered. For this narrative review a very broad search strategy of the literature was developed using both EMBASE and MEDLINE (via PubMed) databases. The reference lists from the selected papers were also scanned, and this provided an additional source of papers for inclusion and further assessment. The data available suggest that diabetes is a risk as well as a modifying factor for periodontitis. Individuals with diabetes are more likely to have periodontitis and with increased severity when diabetes is uncontrolled/poorly controlled. Possible mechanisms of how diabetes affects periodontitis include adipokine-mediated inflammation, neutrophil dysfunction, uncoupling of bone and advanced glycation end-products-receptor for advanced glycation end-products interaction. Evidence is accruing to support how periodontitis can affect diabetes and complications associated with diabetes. There is some evidence demonstrating that periodontal therapy can result in a moderate improvement in glycaemic control. Available evidence indicates that diabetes and peridontitis are intricately interrelated and that each condition has the capacity to influence clinical features of each other.

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“…In addition, overexpression of AGEs/RAGE exacerbates the inflammatory response, thereby aggravating the destruction of periodontal tissue in patients with diabetes [ 20 ]. Periodontitis can aggravate the systemic inflammatory response through persistent bacteremia and elevate the levels of proinflammatory cytokines such as IL-6 and TNF- α [ 21 ], reduce the sensitivity of target cells to insulin, promote insulin resistance [ 22 ], and interfere with the normal metabolism of the body, thereby aggravating the metabolic disorder of diabetes. In brief, periodontitis combined with diabetes aggravates the pathology of these two diseases, so it is necessary to explore a drug that can treat these two diseases simultaneously.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic Potential of Liraglutide for Diabetes–Periodontitis Comorbidity: Killing Two Birds with One Stone

Yang

Pang

Pei

et al. 2022

Journal of Diabetes Research

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Background. The relationship between diabetes and periodontitis is bidirectional, and there is now consensus that periodontitis and diabetes are comorbid. There is a quest for a drug that can be used to treat both conditions simultaneously. This study evaluated the anti-inflammatory and osteoprotective effects of liraglutide (LIRA) on periodontitis in diabetic rats. Methods. Male Wistar rats ( n = 46 ) were randomly divided into four groups: control group ( n = 8 ), LIRA group ( n = 8 ), diabetes-associated periodontitis+0.9% saline group (diabetic periodontitis (DP)+NaCl group, n = 15 ), and diabetes-associated periodontitis+LIRA group (DP+LIRA group, n = 15 ). LIRA treatment lasted for 4 weeks (300 μg/kg/d) after establishment of a rat model of DP. The expression of IL-6, TNF-α, and IL-1β was detected by enzyme-linked immunosorbent assay. The morphological changes of periodontal tissues were observed by hematoxylin–eosin staining. The absorption of alveolar bone and its ultrastructural changes were observed by histomorphometry and microcomputed tomography. The expression of receptor activator of NF-κB ligand (RANKL) and osteoprotegerin (OPG) in alveolar bone was detected by immunohistochemistry. The levels of Runx2 mRNA and ALP mRNA in the gingival epithelium were examined by quantitative real-time polymerase chain reaction. Results. LIRA decreased alveolar bone resorption, improved the microstructure of alveolar bone, and reduced periodontal inflammation and damage ( P < 0.05 ). LIRA also reduced blood glucose level and inhibited the secretion of serum IL-6, TNF-α, and IL-1β ( P < 0.05 ). In addition, after treatment with LIRA, the ratio of RANKL/OPG was reduced, and the expression levels of ALP mRNA and Runx2 mRNA were upregulated ( P < 0.05 ). Conclusions. LIRA not only controls blood glucose level but also reduces inflammation and bone loss and enhances osteogenic differentiation in diabetes-associated periodontitis. Those indicate that LIRA may be used as a potential medicine for the adjunctive therapy of diabetes-periodontitis comorbidity.

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Adiponectin and interleukin-6 levels in insulin-treated diabetic rats with experimental periodontitis

Cited by 5 publications

References 33 publications

Association between metabolic syndrome and periodontitis: The role of lipids, inflammatory cytokines, altered host response, and the microbiome

Association between metabolic syndrome and periodontitis: The role of lipids, inflammatory cytokines, altered host response, and the microbiome

Periodontitis and type II diabetes: a two-way relationship

Therapeutic Potential of Liraglutide for Diabetes–Periodontitis Comorbidity: Killing Two Birds with One Stone

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