Salivary IgA and periodontal treatment needs in diabetic patients

Branco-de-Almeida, Luciana Salles; Alves, Cláudia Maria Coêlho; Lopes, Fernanda Ferreira; Pereira, Adriana de Fátima Vasconcelos; Guerra, Rosane Nassar Meireles; Pereira, Antônio

doi:10.1590/s1806-83242011000600013

Cited by 20 publications

(20 citation statements)

References 27 publications

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“…Type 2 diabetes mellitus patients presented significant differences in the PSR indexes, especially in levels 3 and 4, when compared to nondiabetic individuals, who presented higher prevalence of levels 0, 1, and 2 of the PSR. Such relationship was also verified by (BRANCO-DE-ALMEIDA et al, 2011). Although scores 1 and 2 were slightly higher for non-diabetic patients (control group), there was also a higher prevalence of partially edentulous individuals in the group of type 2 diabetes patients, and this factor may have affected the results negatively.…”

Section: Discussionsupporting

confidence: 54%

Prevalence and severity of periodontal disease in type 2 diabetes mellitus patients: a cross-sectional study

Trentin¹,

Carli²,

Ferreira³

et al. 2018

Biosci. J.

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This is a cross-sectional clinical study performed with type 2 diabetes mellitus patients and nondiabetic patients, in the city of Passo Fundo, RS, Brazil, which aimed to verify whether periodontal disease is more prevalent in type 2 diabetes mellitus (DM2) patients. The study sample included 275 patients, wherein 117 were type 2 diabetes patients and 158 were non-diabetic patients, who were assessed between the years of 2007 and 2010. The inclusion criteria of the study were patients older than 35 years with DM2 diagnosed for more than one year through glycemia and glycosylated hemoglobin tests. The same criteria was used for the control group, except for the presence of diabetes. The participants were evaluated by students calibrated for the Periodontal Screening and Recording (PSR) index and through a questionnaire assessing age, gender, oral hygiene conditions, and medications of the patients. Generalized gingivitis was more prevalent in diabetic patients (p<0.001). The level of oral hygiene of the diabetic patients was considered fair and poor (p<0.001) when compared to the non-diabetic patients. More sextants with periodontal health were observed in non-diabetic patients (p<00.1) when compared to type 2 diabetes mellitus patients; tooth loss was also greater in DM2 patients. The study allowed concluding that DM2 patients presented higher prevalence of periodontal disease than the control group. The factors that might have influenced these results were systemic condition (DM2), level of oral hygiene, and age, which justifies the high rate of periodontal disease and tooth loss in these individuals.

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Section: Discussionsupporting

confidence: 54%

Prevalence and severity of periodontal disease in type 2 diabetes mellitus patients: a cross-sectional study

Trentin¹,

Carli²,

Ferreira³

et al. 2018

Biosci. J.

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“…A Brazilian study reported that diabetic patients with lower s-IgA levels had more severe and frequent periodontal disease. 4 However, two Iranian studies yielded different results: Mohiti-Ardekani et al recorded significantly higher s-IgA levels in diabetic patients while Bakianian Vaziri et al found no significant differences between diabetic and non-diabetic groups. 1,5 Other studies have also reported conflicting results with regards to s-IgA levels and their relationship to various diseases.…”

Section: Advances In Patient Care -Determination Of the Salivary Compmentioning

confidence: 97%

“…As s-IgA plays an important role in protecting against these pathogens, the antibody might also protect against periodontal diseases. 4 Changes in salivary IgA concentrations in diabetic patients could have an effect on their oral health. Several studies have sought to determine salivary flow rates and components that can affect the progression, symptoms and varieties of oral changes in diabetic patients.…”

Section: Advances In Patient Care -Determination Of the Salivary Compmentioning

confidence: 99%

Evaluation of Salivary Secretory Immunoglobulin A Levels in Diabetic Patients and Association with Oral and Dental Manifestations

Kakoei

Hosseini

Haghdoost

et al. 2015

SQUMJ

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abstract:Objectives: Oral and dental manifestations in diabetic patients can arise due to numerous factors, including elevated salivary secretory immunoglobulin A (s-IgA) levels. This study aimed to evaluate s-IgA concentrations in patients with type 2 diabetes mellitus (T2DM) and to investigate the association between s-IgA levels and oral and dental manifestations of T2DM. Methods: This cross-sectional descriptive study was carried out between October 2011 and September 2012 in Kerman, Iran, and included 260 subjects (128 patients with T2DM and 132 healthy controls). Unstimulated salivary samples were collected from all subjects and s-IgA levels were determined using the immunoturbidimetric method. The oral cavities and teeth of T2DM patients were evaluated for oral and dental manifestations. Results: Both diabetic and control subjects with higher concentrations of s-IgA had significantly higher numbers of decayed, missing or filled teeth (DMFT) and periodontal index (PDI) scores (P <0.050). s-IgA levels were significantly higher in subjects with oral candidiasis (P <0.050). Among diabetic patients, significantly higher s-IgA levels were concomitant with xerostomia and denture stomatitis (P ≤0.050). There were no significant differences between s-IgA concentrations and other oral or dental manifestations in either group. Conclusion: Individuals with a greater number of DMFT, a higher PDI score and oral candidiasis had significantly higher s-IgA levels. s-IgA levels were not significantly higher among diabetic patients in comparison to the control group. However, significantly higher s-IgA levels occurred with xerostomia and denture stomatitis in diabetic patients. In addition, s-IgA was significantly higher in patients with uncontrolled diabetes compared to those with controlled diabetes.

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“…It was showed by a proteomic evaluation that cell motility proteins-involved were up or down expressed in saliva from patients with DM versus controls (18). Higher levels of potassium and human α2-macroglobulin and lower expression of s-IgA and EGF secretion rates were also observed in diabetics when compared to healthy subjects by ELISA (19,20). It also has been demonstrated that animals diabetes-induced have important changes in the production of a several different extracellular matrix components and growth factors as TGFβ isoforms for example (8,21).…”

Section: Tgfβ1 In Diabetic and Hypertensive Patientsmentioning

confidence: 99%

Effects of Diabetes and Hypertension on Oral Mucosa and TGFβ1 Salivary Levels

et al. 2018

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in this cross-sectional study, whole stimulated saliva and oral mucosa exfoliative cytology specimens were collected from 39 patients that were healthy (control, n=10) or presented history of arterial hypertension (HAS, n=9), diabetes mellitus (DM, n=10) or both (DM+HAS, n=10). Salivary flow rate (SFR), TGFβ1 level in saliva, AgNORs and the epithelial maturation were evaluated. Non-parametric Kruskal-Wallis test, followed by Dunn's multiple comparison post-test and the Spearman test correlation analysis were used. SFR showed a significant decreased in DM and DM+HAS (0.47±0.11 and 0.64±0.43 mL/min) when compared to control (1.4±0.38 mL/min). DM+HAS presented the highest value of TGFβ1 concentration (24.72±5.89 pg/mL). It was observed a positive correlation between TGFβ1 and glycaemia (R=0.6371; p<0.001) and a negative correlation between TGFβ1 and saliva (R=-0.6162; p<0.001) and glycaemia and SFR (R=-0.5654; P=0.001). AgNORs number and status of maturation of mucosa cells were similar for all conditions. DM and DM+HAS presented the lowest SFR, which correlated with increased TGFβ1 levels. Despite the higher TGFβ1 secretion it was not observed changes in the morphology or proliferation of epithelial cells when diabetes or hypertension was present.

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Salivary IgA and periodontal treatment needs in diabetic patients

Cited by 20 publications

References 27 publications

Prevalence and severity of periodontal disease in type 2 diabetes mellitus patients: a cross-sectional study

Prevalence and severity of periodontal disease in type 2 diabetes mellitus patients: a cross-sectional study

Evaluation of Salivary Secretory Immunoglobulin A Levels in Diabetic Patients and Association with Oral and Dental Manifestations

Effects of Diabetes and Hypertension on Oral Mucosa and TGFβ1 Salivary Levels

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