Trabecular bone area and bone healing in spontaneously hypertensive rats: a histometric study

Bastos, Marta Ferreira; Brilhante, Felipe Vilhena; Bezerra, Joyce Pinho; Alberto-Silva, Carlos; Duarte, Poliana Mendes

doi:10.1590/s1806-83242010000200008

Cited by 24 publications

(21 citation statements)

References 21 publications

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“…[3][4][5] Our results are not in accordance with those of Antolic et al, 15 who have reported benefi cial effects of Cr supplementation on the bone mass of Sprague Dawley rats. Some methodological differences can explain the contradictory results.…”

Section: Discussioncontrasting

confidence: 99%

“…1,2 There is evidence of a reduction in bone mineral density (BMD) in that model, resulting from changes in calcium metabolism, which cause an increase in bone resorption. [3][4][5] While the bone mass of healthy Sprague Dawley rats peaks around the age of 30-36 weeks, SHRs stabilize their bone growth at the age of only 18 weeks. In addition, the peak bone mass in SHRs is approximately 40 mg/cm 2 lower than that in healthy rats.…”

Section: Introductionmentioning

confidence: 99%

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Influência da suplementação de creatina sobre a massa óssea de ratos espontaneamente hipertensos

Alves¹,

Murai²,

Ramona³

et al. 2012

Rev. Bras. Reumatol.

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Introduction: Recent evidence has suggested that creatine supplementation (Cr) can increase the bone mineral density (BMD) of the femur in healthy growing rats. Nevertheless, studies assessing the effi cacy of the Cr supplementation in conditions characterized by bone mass loss are scarce. Objective: To investigate the effect of Cr supplementation on BMD and bone mineral content (BMC) in spontaneously hypertensive rats (SHRs), an experimental model of osteoporosis. Materials and methods: Sixteen 8-month-old male SHRs were randomly allocated into two groups matched by body weight: 1) Pl group: SHRs treated with placebo (distilled water; n = 8); and 2) Cr group: SHRs treated with Cr (n = 8). After nine weeks of supplementation, the animals were euthanized and their femur and spine (L1-L4) were analyzed by use of densitometry (Dual Energy X-Ray Absorptiometry). Results: No signifi cant difference was observed between the groups regarding either the spine or the total femur measures as follows: spine -BMD (Pl = 0.249 ± 0.003 g/cm 2 vs. Cr = 0.249 ± 0.004 g/cm 2 ; P = 0.95) and BMC (Pl = 0.509 ± 0.150 g vs. Cr = 0.509 ± 0.017 g; P > 0.99); and total femur -BMD (Pl = 0.210 ± 0.004 g/cm 2 vs. Cr = 0.206 ± 0.004 g/cm

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Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Influência da suplementação de creatina sobre a massa óssea de ratos espontaneamente hipertensos

Alves¹,

Murai²,

Ramona³

et al. 2012

Rev. Bras. Reumatol.

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show abstract

“…In a ligature-induced periodontitis model and increased RANKL/OPG ratio toward a more osteoclastic condition was observed in the SHR rats versus normotensive controls. 20,21 Hypertension may also negatively affect bone mineral density due to abnormal metabolism of 1,25-dihydroxyvitamin D, a key regulator of calcium homeostasis and bone metabolism, intestinal calcium transport, and angiotensin II-mediated osteoclast activation.…”

Section: Discussionmentioning

confidence: 99%

“…18,19,20,21,22 Few studies can be found correlating endodontic disease and hypertension. Allareddy et al, 23 conducted a retrospective study where they found that 24.6% of patients hospitalized for periapical abscesses were hypertensive.…”

mentioning

confidence: 99%

Relationship between hypertension and periapical lesion: an in vitro and in vivo study

Martins

Sasaki²,

Hirai³

et al. 2016

Braz. oral res.

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The aim of this study was to compare potential aspects of periapical lesion formation in hypertensive and normotensive conditions using hypertensive (BPH/2J) and wild-type control (BPN/3J) mice. The mandibular first molars of both strains had their dental pulp exposed. At day 21 the mice were euthanized and right mandibular molars were used to evaluate the size and phenotype of apical periodontitis by microCT. Proteins were extracted from periapical lesion on the left side and the expressions of IL1α, IL1β and TNFα were analyzed by ELISA. Bone marrow stem cells were isolated from adult mice femurs from 2 strains and osteoclast differentiation was evaluated by tartrate-resistant acid phosphatase (TRAP) in vitro. The amount of differentiated osteoclastic cells was nearly double in hypertensive mice when compared to the normotensive strain (p < 0.03). Periapical lesion size did not differ between hypertensive and normotensive strains (p > 0.7). IL1α, IL1β and TNFα cytokines expressions were similar for both systemic conditions (p > 0.05). Despite the fact that no differences could be observed in periapical lesion size and cytokines expressions on the systemic conditions tested, hypertension showed an elevated number of osteoclast differentiation.

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“…Moreover, evidence suggests that the WKY strain is not the most suitable for backcross studies due to incidence of spontaneous hypertension and somewhat higher levels of blood pressure in these rats 1,2,19,24 . According to several studies 3,11,15,17 , SHRs were compared to Wistar rats, which are safely normotensive and have no genetic alteration that could modulate arterial pressure.…”

Section: Discussionmentioning

confidence: 99%

Alveolar bone healing process in spontaneously hypertensive rats (SHR): A radiographic densitometry study

et al. 2012

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Hypertension is one of the most important public health problems worldwide. If undiagnosed or untreated, this pathology represents a systemic risk factor and offers unfavorable conditions for dental treatments, especially those requiring bone healing.Objectives The purpose of this study was to demonstrate, by analysis of bone mineral density (BMD), that the alveolar bone healing process is altered in spontaneously hypertensive rats (SHRs). Material and Methods Wistar rats and SHRs were submitted to extraction of the upper right incisor and were euthanized 7, 14, 21, 28 and 42 days after surgery. Right maxillae were collected, radiographed and analyzed using Digora software. BMD was expressed as minimum (min), middle (med) and maximum (max) in the medium (MT) and apical (AT) thirds of the dental alveolus. ResultsThe results were compared across days and groups. Wistar showed difference in med and max BMD in the MT between 7 and 28 and also between 14 and 28 days. The AT exhibited significant difference in med and min BMD between 7 and 28 days, as well as difference in min BMD between 28 and 42 days. SHRs showed lower med BMD in the MT at 28 days when compared to 21 and 42 days. Differences were observed across groups in med and min BMD at day 28 in the MT and AT; and in max BMD at 14, 21 and 42 days in the MT. Conclusions These results suggest that the alveolar bone healing process is delayed in SHRs comparing with Wistar rats.

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Trabecular bone area and bone healing in spontaneously hypertensive rats: a histometric study

Cited by 24 publications

References 21 publications

Influência da suplementação de creatina sobre a massa óssea de ratos espontaneamente hipertensos

Influência da suplementação de creatina sobre a massa óssea de ratos espontaneamente hipertensos

Relationship between hypertension and periapical lesion: an in vitro and in vivo study

Alveolar bone healing process in spontaneously hypertensive rats (SHR): A radiographic densitometry study

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