Plasma rich in growth factors and bone formation: a radiological and histomorphometric study in New Zealand rabbits

Molina‐Miñano, Francisco; López‐Jornet, Pía; Camacho-Alonso, Fabio; Vicente-Ortega, Vicente

doi:10.1590/s1806-83242009000300009

Cited by 17 publications

(13 citation statements)

References 18 publications

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“…The results were satisfactory, proving on the short and middle term the effectiveness of such preparations as a supplementary source of stimulation to the physiological deficit, able to promote angiogenesis as well as bone and mucosal wound healing [12][13][14].…”

Section: Introductionmentioning

confidence: 90%

A Report on a 7-year Follow up of the Surgical Management with PRGF®- ENDORET® of Oncologic Patients Affected by Intravenous Bisphosphonate Related Osteonecrosis of the Jaw

Mozzati¹,

Gallesio²,

Pol³

et al. 2013

Surgery Curr Res

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Mozzati et al., Surgery 2013, S12 http://dx.doi.org/10.4172/2161-1076.S12-011 Research ArticleOpen Access AbstractBRONJ is an important complication in bisphosphonate therapy that dramatically influences the patient's quality of life and requires immediate intervention. The situation is worsened by the fact that its management is still an open issue, with no definitive standard of care. The aim of this paper is to present the short, middle and long term (7 years) results of surgical treatment of 32 BRONJ cases involving the use of PRGFNo intraoperative complications were observed; the short period freedom from light complications was 84.4%, with complete remittal in a few weeks; after 7 years the freedom from complications and need of re intervention is 100%. The freedom from onset of a new BRONJ on untreated sites was 100% up to 4 years after which decreased to 82%. The surgical procedure with the applications of platelet-enriched preparations can thus be considered favorably tested, having led to rapid osseous remodeling and to a satisfactory closure of the mucosa thus shielding the area from infection and reducing symptomatology.

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Section: Introductionmentioning

confidence: 90%

A Report on a 7-year Follow up of the Surgical Management with PRGF®- ENDORET® of Oncologic Patients Affected by Intravenous Bisphosphonate Related Osteonecrosis of the Jaw

Mozzati¹,

Gallesio²,

Pol³

et al. 2013

Surgery Curr Res

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“…5, Only 9 (31%) reported randomization. 12,16,19,22,23,27,28,32,36 Ten (34%) stated no conflict of interest. No study described a sample size calculation.…”

Section: Study Qualitymentioning

confidence: 99%

Platelet-Rich Plasma in the Animal Long-Bone Model: An Analysis of Basic Science Evidence

Gianakos¹,

Zambrana²,

Savage-Elliott³

et al. 2015

Orthopedics

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Platelet-rich plasma (PRP) has been suggested as an adjunct to aid in long-bone healing. The purpose of this study was to systematically review the basic science in vivo evidence for the use of PRP in the treatment of bone pathology. The PubMed/MEDLINE and EMBASE databases were screened using the following search criteria: "(Platelet-rich plasma OR PRP OR autologous conditioned plasma OR ACP) AND (bone OR osteocytes OR osteogenesis OR nonunion OR delayed union)." Studies were included if they fulfilled the following criteria: (1) studied the effect of PRP or a similar concentrated platelet product, defined as a blood product with platelet concentration elevated to higher than baseline; (2) established a control with which to compare PRP; (3) were published in a peer-reviewed journal; and (4) looked specifically at animal long-bone models. All review articles and clinical studies, including randomized controlled trials and case series, were excluded from the review. Studies examining the effects of PRP on bones of animals with confounding pathology were excluded. In studies that contained additional treatment variables, only the portion of the experiment that compared PRP directly with the control were evaluated. Data were then extracted with a standardized table. The search yielded 29 articles for inclusion. Seventy-two percent of the studies reported platelet concentrations. Eighty-nine percent of studies reported significant improvement in earlier bone healing on histologic/histomorphometric assessment. One hundred percent showed significant increase in bone formation on radiographs in the PRP group. Eighty percent of studies reported a significant increase in bone area on microcomputed tomography. One hundred percent of studies showed a higher torsional stiffness for the PRP-treated defects. In the in vivo studies evaluated, PRP confers several beneficial effects on animal long-bone models. Proof of concept for PRP as a biologic adjunct in long-bone models has been determined.

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“…Faced with these surprising results, and with reference to the widespread use of PRP outside the hospital 75 PCCS Biopsy ND Thorwarth 54 PCCS Biopsy ND Wiltfang 73 Curasan Biopsy and Rx ND Klongno 85 Curasan Biopsy ND Thorwarth 54 Curasan Biopsy ND Schlegel 83 Curasan Biopsy ND Gerard 86 SmartPreP CT and Rx PO Lee 77 SmartPreP Rx ND Molina-Miñano 87 PRGF Biopsy ND Bovine graft versus bovine graft + PRP Wiltfang 73 PCCS Biopsy and Rx ND Jensen 75 PCCS Biopsy ND Thorwarth 54 PCCS Biopsy ND Wiltfang 73 Curasan Biopsy and Rx ND Thorwarth 54 Curasan Biopsy ND Schlegel 83 Curasan Biopsy ND Torres 70 PRGF Biopsy PO Guerra 88 PRGF Biopsy ND Paknejad 89 PRGF Biopsy ND Bone substitutes versus bone substitutes + PRP.…”

Section: Discussionmentioning

confidence: 99%

“…Wiltfang 73 PCCS β-TCP Biopsy and Rx ND Jensen 75 PCCS β-TCP Biopsy ND Plachokova 90 PCCS β-TCP+ HAP Biopsy ND Wiltfang 73 Curasan β-TCP Biopsy and Rx ND Klongnoi 85 Curasan FHA Biopsy and Rx ND Klongnoi 91 Curasan Biogran® Biopsy and Rx ND Harnack 33 Curasan β-TCP Clinical evaluation ND PRP versus natural healing Weibrich 41 PCCS (liquid) Biopsy ND Roussy 45 PCCS μCT ND Monov 82 Curasan Rx ND Gürbüzer 84 Curasan Bone scintigraphy ND Molina-Miñano 87 PCCS Biopsy ND Torres 70 PCCS Biopsy ND Farina 92 PCCS Biopsy ND CT = computed tomography; FHA = fluorhydroxyapatite; HAP = hydroxyapatite; ND = no difference; PO = positive outcome when using PRP; Rx = radiographic analysis; β-TCP = beta tricalcium phosphate. environment, it is necessary to ask why these preparations do not obtain more favorable results when they appear to function well in vitro.…”

Section: Bone Substitutementioning

confidence: 99%

Platelet‐Rich Plasma: A Study of the Variables that May Influence Its Effect on Bone Regeneration

Jovani-Sancho

Sheth

Mateo

et al. 2015

Clin Implant Dent Rel Res

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Plasma rich in growth factors and bone formation: a radiological and histomorphometric study in New Zealand rabbits

Cited by 17 publications

References 18 publications

A Report on a 7-year Follow up of the Surgical Management with PRGF®- ENDORET® of Oncologic Patients Affected by Intravenous Bisphosphonate Related Osteonecrosis of the Jaw

A Report on a 7-year Follow up of the Surgical Management with PRGF®- ENDORET® of Oncologic Patients Affected by Intravenous Bisphosphonate Related Osteonecrosis of the Jaw

Platelet-Rich Plasma in the Animal Long-Bone Model: An Analysis of Basic Science Evidence

Platelet‐Rich Plasma: A Study of the Variables that May Influence Its Effect on Bone Regeneration

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