Platelet‐Rich Plasma: A Study of the Variables that May Influence Its Effect on Bone Regeneration

Jovani-Sancho, Ma Del Mar; Sheth, Chirag C.; Mateo, Mariano Marqués; Puche‐Torres, Miguel

doi:10.1111/cid.12361

Cited by 13 publications

(8 citation statements)

References 77 publications

(124 reference statements)

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“…Such data and findings of this study highlight the importance of the origin of the PRP. In addition, the discrepancies between the scientific findings related to the use of PPR may be associated with the different preparation protocols 60 .…”

Section: Discussionmentioning

confidence: 99%

Application of Autologous Platelet-Rich Plasma on Tooth Extraction Site Prevents Occurence of Medication-Related Osteonecrosis of the Jaws in Rats

Toro

Mello‐Neto

Santos

et al. 2019

Sci Rep

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This study evaluated the effects of local application of autologous platelet-rich plasma (PRP) on the tooth extraction site of rats presenting the main risk factors for medication-related osteonecrosis of the jaw (MRONJ). For seven weeks, senile rats were submitted to systemic treatment with vehicle (VEH and VEH-PRP) or 100 μg/Kg of zoledronate (ZOL and ZOL-PRP) every three days. After three weeks, the first lower molar was extracted. VEH-PRP and ZOL-PRP received PRP at the tooth extraction site. Euthanasia was performed at 28 days postoperatively. Clinical, histopathological, histometric and immunohistochemical analyses were carried out in histological sections from the tooth extraction site. ZOL showed lower percentage of newly formed bone tissue (NFBT), higher percentage of non-vital bone tissue (NVBT), as well as higher immunolabeling for TNFα and IL-1β. In addition, ZOL presented lower immunolabeling for PCNA, VEGF, BMP2/4, OCN and TRAP. VEH and ZOL-PRP showed improvement in the tooth extraction site wound healing and comparable percentage of NFBT, VEGF, BMP2/4 and OCN. Local application of autologous PRP proved a viable preventive therapy, which is safe and effective to restore tissue repair capacity of the tooth extraction site and prevent the occurrence of MRONJ following tooth extraction.

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Section: Discussionmentioning

confidence: 99%

Application of Autologous Platelet-Rich Plasma on Tooth Extraction Site Prevents Occurence of Medication-Related Osteonecrosis of the Jaws in Rats

Toro

Mello‐Neto

Santos

et al. 2019

Sci Rep

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show abstract

“…Meanwhile, the basement membrane regenerated in wider area in control groups, than in the experimental groups in day-7 specimens. Re-epithelializations in the same period both in the control and experimental group lead One of the reasons of variety of results in PRP studies is high heterogeneity, and this leads to the different conclusions in many studies [15] [16]. In this study, we showed that the application of PRP stimulates wound healing in tooth extraction bone defects; however, the mode of action of the growth factors remains unclear.…”

Section: Discussionmentioning

confidence: 79%

An Experimental Study on the Effects of Platelet Rich Plasma on the Wound Healing of Tooth Extraction-Related Bone Defects

Niimi¹,

Yoshizawa²,

Koyama³

et al. 2017

OJST

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Abstract Platelet-rich plasma (PRP) has been used as a therapeutic tool to promote wound healing, in orthopedics, dermatology, oral surgery, etc. However, the mechanisms underlying the wound healing effects of PRP remain unclear. The purpose of this study was to evaluate the effectiveness of applying PRP, particularly in the management of tooth extraction sockets. Three upper molars of Fischer rats were extracted, and blood was drawn from the hearts of other rats to prepare PRP.

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“…Although these techniques are generally recognised as beneficial, Jovani-Sancho et al indicate in their review that only some of the PRP separation systems (Smart Prep, PRGF ARRANGEMENT) have been scientifically substantiated at least to some degree and even in such cases, only 33 studies, were able to document success of bone turnover procedures. For other systems, such as Curasan or Platelet Concentrate Collection System (PCCS), there has been no success rate of bone augmentation procedures documented in the available studies [17].…”

Section: Discussionmentioning

confidence: 99%

Orthodontic treatment enhanced using PRP: An alternative to Orthognathic surgery?

Foltán¹,

Petr²,

Streblov³

et al. 2019

JDODT

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Background: The aim was to use an alternative technique to orthognathic surgery with similar functional and aesthetic outcome with the added advantages of being less invasive and comfortable to a patient. Here, we evaluate the efficacy of PRP in the acceleration of Orthodontic treatment using Invisalign to correct a malocclusion of Class III with functional reverse bite in a patient who declined surgery but requested the least visible and time consuming procedure. Methods: PRP was applied three times during the course of the therapy. The orthodontic treatment lasted 10 months. The patient was further provided with restorative care. Protrusion of teeth 11, 21, and 22 by bodily movement, shaping of the upper dental arch and rectification of lower incisors were achieved with no adverse effect to the patient’s dental health. Since we assumed that the pathophysiology of the effect of PRP is the same as for corticotomy, we must assume an effect lasting only three months. The great advantage of our method is the fact that it is a minimally invasive technique and hence we could repeat the procedure thrice. Results: Three applications of PRP significantly shortened the length of orthodontic therapy from 21 months to 10 months. Conclusions: We can conclude that although the technique is perhaps a bit lengthy in terms of time taken to achieve the desired results after surgery but it provides a safe alternative approach for patients who decline surgery or instances where surgery cannot be carried out. Keywords: PRP; corticotomy; orthodontic; aligner; Invisalign;

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Platelet‐Rich Plasma: A Study of the Variables that May Influence Its Effect on Bone Regeneration

Abstract: Based on the poor results observed in current literature, the use of PRP in oral surgery cannot be recommended.

Cited by 13 publications

References 77 publications

Application of Autologous Platelet-Rich Plasma on Tooth Extraction Site Prevents Occurence of Medication-Related Osteonecrosis of the Jaws in Rats

Application of Autologous Platelet-Rich Plasma on Tooth Extraction Site Prevents Occurence of Medication-Related Osteonecrosis of the Jaws in Rats

An Experimental Study on the Effects of Platelet Rich Plasma on the Wound Healing of Tooth Extraction-Related Bone Defects

Orthodontic treatment enhanced using PRP: An alternative to Orthognathic surgery?

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