Oral candidiasis in HIV+ patients under treatment with protease inhibitors

Witzel, Andréa Lusvarghi; Silveira, Fernando Ricardo Xavier da; Pires, Maria de Fátima Costa; Lotufo, Mônica Andrade

doi:10.1590/s1806-83242008000400015

Cited by 4 publications

(4 citation statements)

References 25 publications

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“…Candidiasis occurs in organ transplanted patients that are in immunosuppression treatment and carriers of acquired immunodeficiency virus 2,3,5,8,26,30 . If disseminated, these infections are related to high morbidity and mortality levels 1,20 .…”

Section: Introductionmentioning

confidence: 99%

Presence of Candida spp. in the oral cavity of heart transplantation patients

Ribeiro¹,

Bacal²,

Koga-Ito

et al. 2011

J. Appl. Oral Sci.

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Candida spp. can lead to infections or even fungal sepsis particularly among immunocompromized individuals.ObjectiveThe aim of the present study was to analyze the presence of Candida spp. among patients subjected to orthotopic heart transplantation.Material and MethodsOral rinses from 50 patients subjected to orthotopic heart transplantation, aged 13 to 70 years, 40 males and 10 females, were examined. Sexage-oral conditions matched-control included 50 individuals who were not subjected to any kind of transplantation and were not immunocompromized for any other reason. Counts of yeasts were expressed as median values of logarithm of cfu/mL and were statistically compared by Mann-Whitney’s test. The heart transplant and control groups were compared for the presence of Candida spp. by chi-square test (p<0.05).ResultsThe results showed statistically significant difference (p=0.001) in the prevalence of Candida spp. between the transplantation and control groups. Counts of yeasts (cfu/mL) in the transplanted group were significantly higher than in the control group (p=0.005). Candida albicans was the most prevalent species isolated from both groups.ConclusionIt was concluded that Candida yeast counts were higher in the heart transplant recipients than in the controls. There was higher variation of Candida species among the heart transplant patients and the most frequently isolated samples were: Candida albicans, Candida glabrata and Candida tropicalis. Isolates of Candida dubliniensis was not found in either of the groups.

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Section: Introductionmentioning

confidence: 99%

Presence of Candida spp. in the oral cavity of heart transplantation patients

Ribeiro¹,

Bacal²,

Koga-Ito

et al. 2011

J. Appl. Oral Sci.

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“…Apesar de a maioria da literatura apresentar o gênero masculino como o predominante 9,[17][18][19] , neste trabalho observou-se uma predominância do gênero feminino. Esse achado é semelhante aos dados de Cavasin-Filho, Giovani 20 e Noce et al 21 .…”

Section: Discussionunclassified

Aspectos demográficos e manifestações clínicas bucais de pacientes soropositivos para o HIV/Aids

Motta

Nóbrega

Santos

et al. 2014

Rev. odontol. UNESP

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INTRODUÇÃO: As lesões bucais e peribucais são comuns nos pacientes infectados pelo vírus HIV e podem representar os primeiros sinais da doença, antes mesmo das manifestações sistêmicas. OBJETIVO: Este estudo objetivou estimar a prevalência de manifestações bucais em indivíduos soropositivos para o HIV, considerando aspectos sociodemográficos, imunológicos e terapêuticos. MATERIAL E MÉTODO: Foi realizado um estudo de natureza clínico-epidemiológica transversal, entre outubro de 2007 e abril de 2008, com amostra composta por 40 pacientes. Utilizou-se a técnica de observação direta intensiva por meio de exame clínico apropriado. Os dados foram registrados em fichas pré-elaboradas e analisados por estatística descritiva e inferencial. RESULTADO: Verificou-se a prevalência do gênero feminino (52,5%), na faixa etária de 40 a 49 anos (45%). O tratamento com antirretrovirais foi constatado em 85,0% dos casos, sendo todos com terapia de alta potência (HAART). Observou-se que 52,5% dos pacientes apresentaram a contagem de linfócitos TCD4+ acima de 500cél/mm³ e 50,0% apresentaram carga viral indetectável. A prevalência das manifestações bucais foi 42,5%, sendo a mais expressiva a candidose pseudomembranosa (19,23%), seguida da periodontite úlcero-necrosante (15,38%), da leucoplasia pilosa (11,54%) e da queilite angular (11,54%). Não foi verificada associação entre manifestações bucais e carga viral (p=0,1268), nem com o número de células T CD4 (p=0,3458). CONCLUSÃO: A prevalência de algumas manifestações bucais associadas à infecção pelo HIV ainda é alta, sendo a candidose pseudomembranosa a infecção mais prevalente, principalmente entre pessoas com baixo nível de escolaridade e maior tempo de infecção pelo vírus HIV, independentemente da terapia utilizada e do estado imunológico do paciente.

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“… found that CD4 count of patients with pseudomembranous OPC was significantly lower compared to those with erythematous OPC. Witzel also found that CD4 count was associated with clinical forms of OPC . Table showed nine studies considered CD4 < 200 cells/μL as a risk factor for OPC occurrence, of which four studies indicated that CD4 < 200 cells/μL was also associated with pseudomembranous OPC .…”

Section: Candida Colonization and Peripheral Cd4+ T Cell Countmentioning

confidence: 97%

“…Witzel et al. found that protease inhibitors did not affect the prevalence of oral candidiasis (p = 0.158) or C. albicans isolation rate (p = 0.133). Barcheasi considered that antiretroviral regimen did not influence the carriage state .…”

Section: Other Factors Related With Candida Prevalence In Hiv+ Patientsmentioning

confidence: 99%

Oropharyngeal Candida colonization in human immunodeficiency virus infected patients

Lei

Tan

et al. 2012

APMIS

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Oropharyngeal candidiasis (OPC) is a very common oral symptom for HIV infected patients. OPC is often caused by overgrowth of commensal Candida strains which asymptomatically colonize oral cavity of HIV+ patients. HIV infection can not only weaken the systemic and local mucosal immunity but also interact with Candida species colonizing in oral cavity. These changes in host immunity and Candida species may facilitate Candida colonization in oral cavity of HIV infected patients. This review will discuss oral Candida colonization (including asymptomatic Candida carriage and OPC) prevalence, colonization spectrum, colonization intensity, relationship between oropharyngeal Candida colonization and peripheral blood CD4+ T cell counts, association of plasma levels of HIV RNA and Candida colonization, and other factors related with Candida colonization in HIV+ patients.

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Oral candidiasis in HIV+ patients under treatment with protease inhibitors

Cited by 4 publications

References 25 publications

Presence of Candida spp. in the oral cavity of heart transplantation patients

Presence of Candida spp. in the oral cavity of heart transplantation patients

Aspectos demográficos e manifestações clínicas bucais de pacientes soropositivos para o HIV/Aids

Oropharyngeal Candida colonization in human immunodeficiency virus infected patients

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