Ischemia/reperfusion-induced lung injury prevention: many options, no choices

Caruso, Pedro; Gomes, Susimeire

doi:10.1590/s1806-37562016000100002

Cited by 2 publications

(1 citation statement)

References 6 publications

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“…IRI occurs upon resupply of blood after ischemia and is usually associated with apoptosis. [56,57] Generally, IRI includes, but is not limited to, myocardium, kidney, brain, lung, gut, muscle, liver, and spleen. [58][59][60][61][62][63] In addition, it has been found in clinical studies that IRI often does not exist alone and affects the whole body.…”

Section: Mechanism Of Irimentioning

confidence: 99%

Nanoplatform‐Based Reactive Oxygen Species Scavengers for Therapy of Ischemia‐Reperfusion Injury

Wan

et al. 2022

Advanced Therapeutics

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Ischemia‐reperfusion is a characteristic disorder of many diseases, such as myocardial infarction, stroke, and peripheral vascular diseases. Ischemia‐reperfusion injury (IRI) is one of the most frequent causes of debilitating diseases and death. Relieving organ damage caused by IRI is valuable in safeguarding human life and health. In recent years, nanoplatform‐based reactive oxygen species (ROS) scavengers have attracted widespread attention for alleviation of IRI. To highlight these achievements and to provide a quick perspective for researchers to understand the current research status, recent progress in nanoplatform‐based ROS scavengers for IRI therapy is summarized in this review. This review first summarizes information on the main sites and mechanisms of IRI. Thereafter, this review briefly summarizes and discusses the principles of design, fabrication, and administration of nanoplatform‐based ROS scavengers. Furthermore, the application of nanoplatform‐based ROS scavengers in the treatment of IRI in a variety of organs is also reviewed. Finally, limitations and possible breakthrough in developing ROS scavengers in the field of IRI are discussed. It is hoped that this review will be helpful and enlightening to researcher in medicine, pharmacy, biology, chemistry, and materials science.

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Section: Mechanism Of Irimentioning

confidence: 99%

Nanoplatform‐Based Reactive Oxygen Species Scavengers for Therapy of Ischemia‐Reperfusion Injury

Wan

et al. 2022

Advanced Therapeutics

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Assessment of the Effects of Quercetin on Lung Injury After Hind Limb Ischemia Reperfusion in Rats

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Arslan³

et al. 2022

Harran Üniversitesi Tıp Fakültesi Dergisi

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Background: Quercetin has antioxidant and anti-inflammatory effects. Although there are previous animal experi-ments investigating Quercetin’s effect on ischemia reperfusion (IR) injury in the literature, studies involving effect of lower extremity IR on remote organ are rare.Materials and Methods: 18 male Wistar Albino rats were randomly divided into 3 groups, 6 in each group as; Cont-rol (C), Ischemia-reperfusion (IR), IR-Quercetin, (IR-Q). Their weights were between 200-250 g. 30 minutes before the procedure20 mg/kgQuercetin was administered via intraperitoneal route. In the IR groups, infrarenal abdomi-nal aorta was clamped by an atraumatic microvascular clamp. After 120 minutes of ischemia and reperfusion was achieved for another 120 minutes. When reperfusion period ended, tissue samples were taken from the lungs. Malondialdehyde (MDA) level, superoxide dismutase (SOD) and catalase (CAT) enzyme activity and histopathological parameters were compared.Results: We found the MDA level in the IR group higher than the control group (p<0.0001). Lower MDA level was found in the IR-Q group compared tothe IR group (p=0.012). SOD and CAT enzyme activity in the IR group was notably lower in the control group (p<0.0001, p<0.001, respectively). Higher SOD and CAT enzyme activities were found in the IR-Q group compared to the IR group (p=0.012, p<0.001, respectively). Neutrophil infiltra-tion/aggregation, alveolar wall thickness and total lung injury score were notably higher in IR group than in C group (p=0.001, p=0.002, p<0.0001, respectively). In addition, a statistically significant decrease was observed in the Quercetin treated group in neutrophil infiltration/aggregation, alveolar wall thickness and total lung injury score compared to the IR group (p=0.023, p=0.022, p=0.002, respectively).Conclusions: We determined that intraperitoneally administered Quercetin at a dose of 20 mg/kg30 minutes before ischemia in rats reduces lipid peroxidation, oxidative stress and reduces the damage caused by IR in lung histo-pathology.Study findings suggest that Quercetin has a lung protective effect when administered before IR.

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Ischemia/reperfusion-induced lung injury prevention: many options, no choices

Cited by 2 publications

References 6 publications

Nanoplatform‐Based Reactive Oxygen Species Scavengers for Therapy of Ischemia‐Reperfusion Injury

Nanoplatform‐Based Reactive Oxygen Species Scavengers for Therapy of Ischemia‐Reperfusion Injury

Assessment of the Effects of Quercetin on Lung Injury After Hind Limb Ischemia Reperfusion in Rats

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