The halo sign

Marchiori, Edson; Hochhegger, Bruno; Zanetti, Gláucia

doi:10.1590/s1806-37562016000000354

Cited by 5 publications

(1 citation statement)

References 1 publication

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“…This radiologic finding is nonspecific but highly suggestive of angioinvasive fungal infections, most commonly IPA [33]. A broad range of conditions can also be associated with the halo sign, including malignant diseases (hemorrhagic metastases of angiosarcoma or choriocarcinomas, lymphomas, acute leukemia, Kaposi's sarcoma), bacterial infections (tuberculosis and actinomycosis), viral infections (cytomegalovirus, herpes simplex virus, or varicella-zoster virus), Wegener granulomatosis, and transbronchial biopsy [33,34].…”

Section: Challenging Diagnosis Of Ipamentioning

confidence: 99%

Secondary cutaneous aspergillosis in a child with Behçet’s disease: a case-based update

et al. 2023

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Background Invasive aspergillosis (IA) is one of the rarest opportunistic fungal infections and has increased in frequency worldwide in recent years. It is a life-threatening infection associated with high mortality rates. Invasive pulmonary aspergillosis (IPA) is the most severe form of the disease. Extrapulmonary forms can develop as a primary infection or occur as part of a disseminated infection from the lung in severely immunocompromised patients. The major limitation in the management of these infections is the challenge of early diagnosis. Case presentation Here we report a case of secondary cutaneous aspergillosis that developed from extensive pulmonary aspergillosis in a 3-year-old female who underwent immunosuppressive therapy for a diagnosed Behçet disease (BD). Aspergillus hyphae were identified on skin biopsies. Cultures grew Aspergillus fumigatus. The diagnosis of cutaneous aspergillosis enabled us to diagnose IPA, although there was no mycopathological proof of lung infection. The patient was successfully treated with voriconazole (8 mg/kg/day) and surgical debridement of the skin lesion. Conclusions Although cutaneous involvement in aspergillosis is extremely uncommon, it may be the presenting feature in some cases, allowing for an accurate and timely diagnosis of deeply infected sites. Accordingly, when evaluating skin lesions in immunocompromised individuals, especially debilitated children with underlying diseases requiring long-term immunosuppressive agents, cutaneous aspergillosis should be vigilantly considered.

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Section: Challenging Diagnosis Of Ipamentioning

confidence: 99%