Types of outcomes in clinical research

Ferreira, Juliana Carvalho; Patino, Cecilia María

doi:10.1590/s1806-37562017000000021

Cited by 30 publications

(29 citation statements)

References 2 publications

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“…Analyzing the COVID-19 related clinical trials provides the following insights: Outcomes are events (e.g., patient death or discharge from the hospital) that are actively being monitored in a clinical trial [ 13 ]. As depicted in Fig 4 , the majority of outcomes either deal with acute lung disease, time to clinical improvement, antibodies, or, unfortunately, mortality.…”

Section: Resultsmentioning

confidence: 99%

Analysis of COVID-19 clinical trials: A data-driven, ontology-based, and natural language processing approach

Alag¹

2020

PLoS ONE

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With the novel COVID-19 pandemic disrupting and threatening the lives of millions, researchers and clinicians have been recently conducting clinical trials at an unprecedented rate to learn more about the virus and potential drugs/treatments/vaccines to treat its infection. As a result of the influx of clinical trials, researchers, clinicians, and the lay public, now more than ever, face a significant challenge in keeping up-to-date with the rapid rate of discoveries and advances. To remedy this problem, this research mined the ClinicalTrials.gov corpus to extract COVID-19 related clinical trials, produce unique reports to summarize findings and make the meta-data available via Application Programming Interfaces (APIs). Unique reports were created for each drug/intervention, Medical Subject Heading (MeSH) term, and Human Phenotype Ontology (HPO) term. These reports, which have been run over multiple time points, along with APIs to access meta-data, are freely available at http:// covidresearchtrials.com. The pipeline, reports, association of COVID-19 clinical trials with MeSH and HPO terms, insights, public repository, APIs, and correlations produced are all novel in this work. The freely available, novel resources present up-to-date relevant biological information and insights in a robust, accessible manner, illustrating their invaluable potential to aid researchers overcome COVID-19 and save hundreds of thousands of lives.

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Section: Resultsmentioning

confidence: 99%

Analysis of COVID-19 clinical trials: A data-driven, ontology-based, and natural language processing approach

Alag¹

2020

PLoS ONE

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“…It is similar to an equivalence trial but it differs based on the hypothesis and the statistical test used to determine power. Outcome ‐ Is the variable that is measured in a trial to evaluate the effectiveness of an intervention or exposure. Primary outcomes are the most critical into answering the research question, whilst secondary outcomes assist in the interpretation and understanding of the primary outcomes (Ferreira & Patino 2017). Outcome measure – The objective/quantitative measurement of the outcome variable.…”

Section: Glossary Listmentioning

confidence: 99%

Glossary for randomized clinical trials

et al. 2020

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Randomized clinical trials are positioned at the highest level of primary clinical evidence, as they are designed to be unbiased with a reduced risk of systematic error. The Consolidated Standards of Reporting Trials (CONSORT) statement was first developed in 1996 to improve the reporting quality of randomized clinical trials with updates being published subsequently. Recently, the Preferred Reporting Items for RAndomized Trials in Endodontics (PRIRATE) 2020 guidelines were developed exclusively for the field of Endodontics to address the suboptimal quality of randomized clinical trials submitted to Endodontic journals, which result in many being rejected. A principal flaw in submissions is the fact that many authors are unclear on the keys terms that should be used when developing manuscripts for publication. Clearly, authors should be aware of the most common terms used when conducting and reporting randomized clinical trials. Hence, the aim of the current paper is to present a comprehensive glossary of the terminology used in randomized clinical trials in order to assist authors when designing, executing and writing‐up randomized clinical trials.

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“…4 Clinical outcome can be conceptualized as a variable used to record the outcome of the treatment, such as cure (discharge) or clinical deterioration, which can lead to death. 5 In this perspective, the question is: What have been the clinical outcomes of patients admitted to a Coronary Unit located in the southern region of Mato Grosso? And what sociodemographic factors may be related to clinical outcomes?…”

Section: Introductionmentioning

confidence: 99%

Clinical outcome of patients hospitalized in a coronary intensive care unit

Silva

Maier

Soares

et al. 2020

R.pesq.:cuid.fundam.Online

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Objetivo: Verificar quais os desfechos clínicos dos usuários internados em uma Unidade de Terapia Intensiva Coronariana de um hospital no sul de Mato Grosso. Método: Estudo do tipo coorte retrospectivo, documental, com abordagem quantitativa, com 593 usuários durante o ano de 2017. Resultados: Verificou-se significância em relação ao desfecho clínico óbito no bloco de distúrbios mecânicos, em relação ao número menor de admissões e proporcionalmente um aumento do desfecho óbito com 36,3% o que reflete a associação estatística entre as variáveis (p-valor=0,0184); Também é imperativo destacar a relação entre o número de altas e de óbitos a partir do décimo sexto dia de internação, ocorrendo associação entre as varáveis (p-valor= 0,00001). Conclusão: Espera-se que a partir dos dados sociodemográficos e clínicos dos usuários atendidos, a instituição consiga implementar da assistência ofertada, com foco no atendimento especializado, de modo a repercutir na redução do desfecho óbito na Unidade Coronariana.

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Types of outcomes in clinical research

Cited by 30 publications

References 2 publications

Analysis of COVID-19 clinical trials: A data-driven, ontology-based, and natural language processing approach

Analysis of COVID-19 clinical trials: A data-driven, ontology-based, and natural language processing approach

Glossary for randomized clinical trials

Clinical outcome of patients hospitalized in a coronary intensive care unit

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