Lung cancer: changes in histology, gender, and age over the last 30 years in Brazil

Mao

et al. 2020

CMAR

Introduction: Our aim was to determine the relationship between surgical compliance and survival outcomes in patients with stage T1-2 non-small-cell lung cancer (NSCLC). Methods: Patients with T1-2 NSCLC who were diagnosed between 2004 and 2015 were identified from the SEER database. Multivariate logistic regression was used to analyse factors associated with surgical compliance. Kaplan-Meier curves and Cox regression were used to analyse the effects of surgical compliance on overall survival (OS) and cancer-specific survival (CSS). Results: Of the 221,704 eligible T1-2 NSCLC patients, 106,668 patients recommended surgery. Among them, 99,672 (93.4%) patients were surgical compliance group, and 6996 (6.6%) were surgical noncompliance group. Poor surgical compliance was associated with earlier diagnosis time, old age, male, black race, unmarried status, main bronchus site, poor grade/stage, and lower household income. Patients' compliance was an independent prognostic factor for OS and CSS of T1-2 NSCLC patients. Multivariate Cox regression showed that surgical noncompliance individuals showed lower OS (hazard ratio [HR] 2.494; 95% confidence interval [CI] 2.423-2.566, p < 0.001) and lower CSS (HR 2.877; 95% CI 2.782-2.974, p < 0.001) compared with surgical compliance patients. In addition, results in the non-surgical group were observed to be similar to those of the surgical noncompliance group. Conclusion: We found that patients' compliance was an independent prognostic factor for survival in T1-2 NSCLC patients. Poor surgical compliance was associated with earlier diagnosis time, old age, male, black race, unmarried status, main bronchus site, poor grade/ stage, and lower household income.

Section: Introductionmentioning

confidence: 99%

<p>Surgical Compliance and Survival Outcomes for Patients with Stage T1-2 Non-Small-Cell Lung Cancer</p>

Mao

et al. 2020

CMAR

“…A previous report found that percutaneous CT-guide biopsy had a diagnostic yield of 93%, higher than that of bronchoscopy biopsy at 75%. Additionally, the proportion of the more commonly regarded centrally located squamous cell carcinoma has decreased over the past 30 years, from 49.6% to 34.8% [21]. Moreover, traditionally recognized centrally located squamous cell carcinoma has been reported to consist of more than 62% of squamous cell carcinoma [22].…”

Section: Discussionmentioning

confidence: 99%

Utilization and Safety of Percutaneous Lung Biopsy: A 10-Year Nationwide Population-Based Study

Chen

Chang

Chen

et al. 2019

IJERPH

Percutaneous lung biopsy is a technique used for sampling peripherally located lung masses and has been gaining in popularity. However, its exact utilization is unknown, and its safety has not been well studied. The current study aimed to assess the trend of utilization and study the safety of this procedure. Using the National Health Insurance Research Database, we retrospectively determined the total number of procedures that were performed on subjects older than 20 years between 2001 and 2010. We also estimated the rates of major complications, such as pneumothorax, requiring intercostal drainage. A total of 630 percutaneous biopsies were performed in 2001, while 3814 were performed in 2010, representing a 6.1-fold increase. The compound annual growth rate was 22.1%. The number of hospitals that performed the procedure increased from 55 to 99. Pneumothorax requiring drainage occurred in 1.5% of the procedures. The factors associated with a higher complication rate included male gender, chronic obstructive pulmonary disease, rural hospital, and low-volume hospital. Percutaneous lung biopsies are a relatively safe procedure, and their performance has been rapidly increasing. The number of procedures performed by a hospital was associated with the complication rate.

“…The profile found is consistent with what has been identified in recent years in developed countries, as well as in Brazil. Even though it is an underdeveloped country, due to the great efforts in anti-smoking actions, we have seen the altered epidemiology of lung cancer in recent years, with an increase in the incidence of adenocarcinoma and a decrease in squamous cell carcinoma according to Tsukazan et al [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Solid Neoplasms Diagnosed Between the Years of 2011 to 2016 and Oncologically Treated at the University Hospital of Santa Maria

et al. 2019

BackgroundCancer is a public health problem, especially in developing countries. In order to establish effective measures for the cancer control, there is a need for quality information, thus enabling a better understanding of the disease and its determinants, formulation of causal hypotheses, evaluation of the technological advances applied to prevention and treatment as well as the effectiveness of health care. The objective of the study was to investigate the prevalence of solid neoplasms diagnosed between the years 2011 to 2016 and treated at the Oncology Department of the University Hospital of Santa Maria and the existing oncological context.MethodsThis is an observational cross-sectional study. The target population was comprised of adult patients (18 years of age or older) and elderly people (60 years of age or older) diagnosed with solid cancer by anatomico-pathological examination between 2011 and 2016, who started oncological treatment, according to high complexity procedure authorization (APAC)/Oncology.ResultsA total of 2,757 patients were selected, of which 1,493 patients were female (54.2%) and 1,264 male (45.8%). The mean age at the time of initiation of treatment was 59.94 years for both sexes, with the 95% confidence interval (59.44 - 60.44). The majority of patients were aged 61 - 70 years, totaling 747 patients, followed by 718 patients between 51 - 60 years. In all 31 primary sites identified the most prevalent one of neoplasms are breast, prostate, colorectal and lung; and most cases were stage IV (1,039 cases). A percentage of the number of cases of breast and esophageal cancer was higher than expected, and in contrast to a low percentage of hepatocarcinoma, kidney cancer and central nervous system tumors. The patients came from the entire area of the fourth Health Coordinating Area, where 100% of the municipalities referred to the institution, as well as other nine locations belonging to other coordinators.ConclusionMost of the data obtained are consistent with the Brazilian reality, not identifying any peculiar characteristic of this region of the study worthy of note, except for the difference in the prevalence of some types of cancer, a fact that deserves further studies. There were also no discrepancies in a regional analysis. Along with this work, it was possible to demonstrate the cancer situation and the profile of oncology patients attended at a reference center for 41 municipalities, mainly in the central region of Rio Grande do Sul state, which may be useful in the elaboration of public policies to modify the profile identified, and serve as the basis for further studies in this region.