Factors associated with malnutrition in adolescent and adult patients with cystic fibrosis

Barni, Gabriela Cristofoli; Forte, Gabriele Carra; Forgiarini, Luis Felipe; Abrahão, Claudine Lacerda de Oliveira; Dalcin, Paulo de Tarso Roth

doi:10.1590/s1806-37562016000000319

Cited by 11 publications

(10 citation statements)

References 32 publications

(45 reference statements)

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“…Association of FEV 1 % with BMI percentile is well recognized 4 6 , 17 , 18 Our data demonstrated that being below the BMI 25th percentile was associated with 12% lower FEV 1 %. Stallings et al 6 showed that BMI percentiles at 25th was associated with FEV 1 % status below 90% predicted in subjects aged 6 to 12 years old, and below 80% in subjects aged 13 to 20.…”

Section: Discussionsupporting

confidence: 61%

Body Mass Index and Albumin Levels Are Associated With Pulmonary Function Parameters in Pediatric Subjects With Cystic Fibrosis

Simon

Forte

Maróstica

2019

Rev. paul. pediatr.

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Objective: To evaluate the association of body mass index (BMI) and albumin with pulmonary function in cystic fibrosis (CF) pediatric subjects.Methods: This is a cross-sectional study with clinically stable CF’s subjects. Clinical (pulmonary function) and nutritional evaluation (body mass index and albumin) were performed. Univariate analysis was performed using simple linear correlations. Regression analysis was performed using an exit level of p<0.05.Results: Seventy-eight CF’s subjects (mean age 12.8±3.8 years) with mean albumin 4.2±0.4 mg/dL, predicted forced expiratory volume in 1 second (FEV1%) 80.8±22.6 and BMI median percentile 51.2 (1.3-97.7). In the multiple regression models, albumin, age and BMI percentile were associated with pulmonary function. Subjects with lower than 25 BMI percentile had 12.2% lower FEV1%. An albumin increase of 0.1 mg was associated with 2.7% increase in predicted FEV1%, and one year increase in age was associated with reduction in 1.2% of predicted FEV1%.Conclusions: BMI percentile, albumin and age were independently associated with predicted FEV1% in a tertiary referral hospital.

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Section: Discussionsupporting

confidence: 61%

Body Mass Index and Albumin Levels Are Associated With Pulmonary Function Parameters in Pediatric Subjects With Cystic Fibrosis

Simon

Forte

Maróstica

2019

Rev. paul. pediatr.

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“…At presentation, 45.5% of the present study’s CF patients had malnutrition according to the Waterlow malnutrition classification, versus a malnutrition rate of 19.5% according to the WHO malnutrition definition. According to Panagopoulou 20 and Barni, 21 the worldwide frequency of acute malnutrition at baseline is 24.7% and 21.1%, respectively, versus 19.5% in the present study.…”

Section: Discussioncontrasting

confidence: 47%

The effects of nutritional status and intervention on pulmonary functions in pediatric cystic fibrosis patients

Kılınç¹,

Beşer²,

Ugur

et al. 2021

Pediatrics International

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Background: Cystic fibrosis (CF) causes malabsorption of nutrients that exacerbate pulmonary problems. Nutritional interventions can improve pulmonary functions. We aimed to evaluate the effects of nutritional intervention in CF patients with malnutrition, and to determine if there is a correlation between nutritional status and pulmonary functions. Methods: The study included 143 CF patients (67 females) with a mean 2 year follow-up time. Patients' sociodemographic data, presenting symptoms and history were recorded. Height-forage , weight-forage , weight-for-length/ height (WFL/H), and body mass index (BMI) were calculated in all patients. Patients were grouped as well nourished, mild malnutrition, moderate malnutrition, and severe malnutrition. These four groups were compared in terms of pulmonary function test results, lung infections, and the hospitalization rate. Results: Among the patients with a WFL/H or BMI z-scores that decreased, the frequency of lung infection was 74.1% and the hospitalization rate was 40.7%, versus 34% and 12.3%, respectively among the patients with a WFL/H or BMI z-scores that increased. The difference was significant (P = 0.02 and P = 0.01, respectively). The difference in bacterial lung infections differed significantly between the four nutritional status groups (P = 0.002). Patients in the well-nourished group had significantly higher pulmonary function test scores than the other groups. The forced expiratory volume in the first second differed significantly between the patients with and without an increase in the WFL/H or BMI z-scores (P = 0.001). Conclusions: The appropriate nutritional intervention to pediatric CF patients with malnutrition, decrease the frequency of lung infections, and improve respiratory function.

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“…6 En nuestro estudio, solo el 29% de los pacientes mayores de 20 años registrados hasta 2017 alcanzaron dicha meta, porcentaje sensiblemente inferior al publicado en el Registro de la Fundación Americana de Fibrosis Quística de 2016 (51%)6 y por Barni (43,8%). 45 En nuestro centro el IMC promedio fue 21,5 ±2,6 kg/ m 2 , resultado similar al publicado por Barni45 en una serie de 73 pacientes en Brasil que dan una cifra promedio de 21,0 ± 3,0 kg/m 2 y una serie de 58 pacientes en Chile publicado por Fernández, 46 con un valor de IMC promedio de 22 ± 3,4 kg/m 2 .…”

Section: Discussionunclassified

Impacto de la afectación hepatobiliopancreática y el estatus nutricional en la sobrevida de adultos con fibrosis quística

́Ascenzo¹,

Bosia²,

Borzi³

et al. 2020

Acta gastroenterol. latinoam.

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The increase survival of adult patients with Cystic Fibrosis (CF) has generated a greater relevance of extra pulmonary disease. Objective. Determine digestive, nutritional commitment and its impact on the survival of adult patients with CF. Methods. Retrospective, descriptive and comparative study of 100 adult patients with CF, assisted between 2003 and 2017. It was evaluated: clinical parameters, genetic, body mass index (BMI), respiratory function tests, bacteriological sputum, pancreatic insufficiency (PI), CF-related diabetes (CFRD), acute pancreatitis (AP), liver cirrhosis and biliary lithiasis. Results. 100 patients were evaluated [median age: 26 years (range: 16-65)]. Median age at diagnosis: 2 years. Mean BMI 21.5 ± 2.6 SD kg/m2. PI 69/100 (69%), CFRD 29 patients (29%), AP 4 patients (4%). Liver cirrhosis 6 patients (6%) and biliary lithiasis 21 patients (21%).Median Forced Expiratory Volume in first second (FEV1) 50%. Most frequent mutation ΔF508 (54%). Fourteen patients (14%) malnourished. Pseudomonas aeruginosa was the most frequent colonizing microorganism (67%), with a median overall survival of 160 months (95% CI 131-160). We found lower survival in those patients who had PI [(mean 124.2 vs. 136 months (p = 0.4)], malnutrition [median 60 vs. 160 months (p = 0.001)] and cirrhosis [median 36 vs. 160 months (p = 0.003).] Conclusion. Digestive diseases and malnutrition influence negatively in the survival of adult patients with CF.

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Factors associated with malnutrition in adolescent and adult patients with cystic fibrosis

Cited by 11 publications

References 32 publications

Body Mass Index and Albumin Levels Are Associated With Pulmonary Function Parameters in Pediatric Subjects With Cystic Fibrosis

Body Mass Index and Albumin Levels Are Associated With Pulmonary Function Parameters in Pediatric Subjects With Cystic Fibrosis

The effects of nutritional status and intervention on pulmonary functions in pediatric cystic fibrosis patients

Impacto de la afectación hepatobiliopancreática y el estatus nutricional en la sobrevida de adultos con fibrosis quística

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