Body Mass Index and Albumin Levels Are Associated With Pulmonary Function Parameters in Pediatric Subjects With Cystic Fibrosis

Simon, Míriam Isabel Souza dos Santos; Forte, Gabriele Carra; Maróstica, Paulo José Cauduro

doi:10.1590/1984-0462/;2019;37;4;00016

Cited by 5 publications

(7 citation statements)

References 19 publications

(24 reference statements)

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“…A study of African Americans with no cardiopulmonary or chest wall disease showed that BMI was negatively correlated with DLCO 21 . Another study on patients with COPD from China showed that BMI was positively correlated with DLCO and DLCO/VA 22 .A series of clinical studies on IPF showed that lower BMI is associated with a poorer outcome of IPF 23 – 25 , but indexes of pulmonary diffusion function were not observed in these studies. We speculate that better nutritional status may promote the recovery of lung injury from severe COVID-19, as BMI can be considered as an indicator of nutrition.…”

Section: Discussionmentioning

confidence: 96%

Eight months follow-up study on pulmonary function, lung radiographic, and related physiological characteristics in COVID-19 survivors

Zhang

Bai

Yue

et al. 2021

Sci Rep

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To describe the long-term health outcomes of patients with COVID-19 and investigate the potential risk factors. Clinical data during hospitalization and at a mean (SD) day of 249 (15) days after discharge from 40 survivors with confirmed COVID-19 (including 25 severe cases) were collected and analyzed retrospectively. At follow-up, severe cases had higher incidences of persistent symptoms, DLCO impairment, and higher abnormal CT score as compared with mild cases. CT score at follow-up was positively correlated with age, LDH level, cumulative days of oxygen treatment, total dosage of glucocorticoids used, and CT peak score during hospitalization. DLCO% at follow-up was negatively correlated with cumulative days of oxygen treatment during hospitalization. DLCO/VA% at follow-up was positively correlated with BMI, and TNF-α level. Among the three groups categorized as survivors with normal DLCO, abnormal DLCO but normal DLCO/VA, and abnormal DLCO and DLCO/VA, survivors with abnormal DLCO and DLCO/VA had the lowest serum IL-2R, IL-8, and TNF-α level, while the survivors with abnormal DLCO but normal DLCO/VA had the highest levels of inflammatory cytokines during hospitalization. Altogether, COVID-19 had a greater long-term impact on the lung physiology of severe cases. The long-term radiological abnormality maybe relate to old age and the severity of COVID-19. Either absent or excess of inflammation during COVID-19 course would lead to the impairment of pulmonary diffusion function.

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Section: Discussionmentioning

confidence: 96%

Eight months follow-up study on pulmonary function, lung radiographic, and related physiological characteristics in COVID-19 survivors

Zhang

Bai

Yue

et al. 2021

Sci Rep

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“…Poor nutritional status and reduced BMI are associated with lower lung function and increased mortality in CF [ 9 , 14 , 16 ], and therefore undoubtedly contribute to the sex disparity in CF survival. Furthermore, CF women have been found to have poorer medication and nutritional adherence, which may also contribute to reduced lung function [ 17 , 18 ] and worse health outcomes [ 19 ].…”

Section: The “Gender Gap” In Cf Survival and Pulmonary Outcomesmentioning

confidence: 99%

Sex disparities in cystic fibrosis: review on the effect of female sex hormones on lung pathophysiology and outcomes

et al. 2020

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Sex differences in morbidity and mortality have been reported in the cystic fibrosis (CF) population worldwide. However, it is unclear why CF women have worse clinical outcomes than men. In this review, we focus on the influence of female sex hormones on CF pulmonary outcomes and summarise data from in vitro and in vivo experiments on how estrogen and progesterone might modify mucociliary clearance, immunity and infection in the CF airways. The potential for novel sex hormone related therapeutic interventions is also discussed.

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“…The associations of albumin and BMI with PF have been addressed in several studies [13]. For example, BMI and albumin have been reported to be independently associated with the predicted FEV1% in children with cystic brosis [13]. In addition, a correlation between FEV1 and BMI has been found by Popova et al in patients treated for pulmonary TB, with a level of 0.14 (P < 0.05) [14].…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, impairment of PF may then occur due to reduced physical activity (muscle atrophy) [11,12]. The associations of albumin and BMI with PF have been addressed in several studies [13]. For example, BMI and albumin have been reported to be independently associated with the predicted FEV1% in children with cystic brosis [13].…”

Section: Discussionmentioning

confidence: 99%

Impaired pulmonary function and associated factors in the elderly with tuberculosis on admission

He¹,

Yang²,

Zhang³

et al. 2022

Preprint

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Background: Pulmonary tuberculosis (TB) can impair pulmonary function (PF), especially in the elderly. However, little is known regarding which risk factors contribute to impaired PF among the elderly with pulmonary TB.Methods: From January 2019 to February 2022, the elderly who were admitted to our hospital for pulmonary TB and underwent PF testing were included in this analysis. The forced expiratory volume in one second (FEV1) and clinical characteristics were collected and analyzed retrospectively. The extent of impaired PF was then categorized based on the FEV1 and classified as grade 1–5. Logistic regression analysis was used to analyze the risk factors for impaired PF.Results: A total of 249 patients who met the enrollment criteria were included in this analysis. According to the results of FEV1%, all patients were classified as grade 1 (n=37), grade 2 (n=46), grade 3 (n=55), grade 4 (n=56), or grade 5 (n=55). Statistical analysis showed that albumin (OR=0.928, P=0.013), body mass index (BMI)<18.5 kg/m2 (OR=4.968, P=0.046), lesion number≥3 (OR=4.229, P<0.001), male (OR=2.252, P=0.009), respiratory disease (OR=1.669, P=0.046), and cardiovascular disease (OR=2.489, P=0.027) were related to airway obstruction.Conclusions: A decline in PF is common in the elderly with pulmonary TB. The male sex, BMI<18.5 kg/m2, lesion number≥3, hypoproteinemia, and respiratory and cardiovascular comorbidities were identified as risk factors for a significant decline in PF. Our findings may be helpful to improve the current management of pulmonary TB in the elderly to save their lung function.

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Body Mass Index and Albumin Levels Are Associated With Pulmonary Function Parameters in Pediatric Subjects With Cystic Fibrosis

Cited by 5 publications

References 19 publications

Eight months follow-up study on pulmonary function, lung radiographic, and related physiological characteristics in COVID-19 survivors

Eight months follow-up study on pulmonary function, lung radiographic, and related physiological characteristics in COVID-19 survivors

Sex disparities in cystic fibrosis: review on the effect of female sex hormones on lung pathophysiology and outcomes

Impaired pulmonary function and associated factors in the elderly with tuberculosis on admission

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