Low-dose CT screening for lung cancer in Brazil: a study protocol

Santos, Ricardo Sales dos; Franceschini, Juliana; Kay, Fernando Uliana; Chate, Rodrigo Caruso; Júnior, Altair da Silva Costa; Oliveira, Fernando Nunes; Trajano, André Luiz C.; Pereira, José Rodrígues; Succi, José Ernesto; Saad, Roberto

doi:10.1590/s1806-37132014000200016

Cited by 6 publications

(5 citation statements)

References 7 publications

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“…Initial results from BRELT1 17 indicated 39.4% of 790 participants had positive CT scans, significantly different from results of the NLST, and a non–small-cell lung cancer prevalence of 1.3%, similar to that of NLST and other studies. These results support the role of lung cancer screening in countries with a high incidence of granulomatous inflammation.…”

Section: Establishment Of Lung Cancer Screening By Ldct Scan Of the Csupporting

confidence: 51%

“…There are > 20 countries in LATAM, but we are using the example of Brazil because of the large number of people that live there and because it is the first country in LATAM to be more in favor of LDCT. After the publication of the results from the NLST, 16 the First Brazilian Lung Cancer Screening Trial (BRELT1) 17 was established—the first program for lung cancer screening in Brazil. The program became active in 2013, with the goal of recruiting 1,000 individuals at high risk for lung cancer for LDCT screening and a comprehensive smoking cessation program.…”

Section: Establishment Of Lung Cancer Screening By Ldct Scan Of the Cmentioning

confidence: 99%

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Challenges in Lung Cancer Screening in Latin America

Raez

Nogueira

Santos

et al. 2018

JGO

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Lung cancer is the deadliest cancer worldwide and is of particular concern for Latin America. Its rising incidence in this area of the world poses myriad challenges for the region’s economies, which are already struggling with limited resources to meet the health care needs of low- and middle-income populations. In this environment, we are concerned that regional governments are relatively unaware of the pressing need to implement effective strategies for the near future. Low-dose chest computed tomography (LDCT) for screening, and routine use of minimally invasive techniques for diagnosis and staging remain uncommon. According to results of the National Lung Screening Trial, LDCT lung cancer screening provided a 20% relative reduction in mortality rates among at-risk individuals. Nevertheless, this issue is still a matter of debate, particularly in developing countries, and it is not fully embraced in developing countries. The aim of this article is to provide an overview of what the standard of care is for lung cancer computed tomography screening around the world and to aid understanding of the challenges and potential solutions that can help with the implementation of LDCT in Latin America.

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Section: Establishment Of Lung Cancer Screening By Ldct Scan Of the Csupporting

confidence: 51%

Section: Establishment Of Lung Cancer Screening By Ldct Scan Of the Cmentioning

confidence: 99%

Challenges in Lung Cancer Screening in Latin America

Raez

Nogueira

Santos

et al. 2018

JGO

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“…[10] There had been no lung cancer screening studies in Latin America until the Brazilian Early Lung Cancer Detection Trial (BRELT -ProPulmão) was initiated in Brazil. [11] The subsequent BRELT1 and BRELT2 studies contributed data and insights on lung cancer prevalence and screening efficacy. [12,13] The current BRELT3 study aims to investigate the challenges associated with implementing lung cancer screening programs in remote regions distant from major urban centers, where access to healthcare and resources is often scarce.…”

Section: Introductionmentioning

confidence: 99%

Mobile Lung Cancer Screening in Limited Resource Regions: The ProPulmão Project (BRELT3) Study Protocol

dos Santos,

Figueiredo,

Franceschini

et al. 2024

Preprint

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Background Lung cancer is a highly aggressive disease that affected almost 2.2 million people worldwide and caused 1.8 million deaths in 2020. Smoking as well as being exposed to cancer-causing substances in the workplace are significant contributors to the chance of developing cancer. Developing countries encounter distinctive obstacles in the implementation of lung cancer screening because of extensive geographical and socioeconomic disparities. Objectives: our primary objective is to describe tomographic findings in a high-risk lung cancer population in limited resource Brazilian areas. The secondary objectives are to quantify the frequency of pulmonary nodules (especially those falling into Lung-RADS categories 3 and 4) as well as the occurrence of lung cancer; to describe and analyze the challenges related to lung cancer screening programs in the context of Brazilian public health system; to explain the pulmonary function pattern and clinical characteristics of individuals diagnosed with moderate or severe emphysema by low-dose computed tomography (LDCT); and to evaluate the commitment of Community Health Assistants in actively recruiting the high-risk population. Methods: This is a prospective cohort study. The study includes individuals in an age range of 50 to 80 years who are either current or former smokers and have a smoking history of at least 20 pack-years. They undergo LDCT with a planned follow up of 12 months. All adverse events are monitored and assisted. The classification of screening results is performed according to the Lung-RADS standards. Individuals classified in categories 3 and 4 receive additional diagnostic assessments and may have further testing. Expected results: we expect this study shows the feasibility and effectiveness of lung cancer screening in people in situation of social vulnerability within limited resource settings, providing vital knowledge to reduce mortality and improve health outcomes. The project will generate relevant knowledge to inform policies on lung cancer screening within the Brazilian public health system, emphasizing the necessity of timely identification and action in limited resource settings. Outcome: The study's dissemination plan includes a website, social media, and participation in scientific conferences. Approval from the ethics committee has been obtained, and rigorous mechanisms are in place to guarantee the privacy of the data.

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“…The LC screening studies have proposed the nodule management protocol based on parameters specified by the thoracic oncology groups or strategies recommended by the Fleischner society. 7,[9][10][11][12] In Brazil, the LC screening is not well defined by the public health practice, however the First Brazilian Lung Cancer Screening Trial (BRELT1) reported 312 participants (of 790 cases) were positive LDCT scans, with nodules larger than 4 mm. 11 The large number of positive scans in brazilian patients could reflect on the high incidence of tuberculosis.…”

Section: Introductionmentioning

confidence: 99%

Lung-RADS usado no rastreamento do câncer de pulmão: a doença granulomatosa faz diferença?

Noschang¹,

Chaves²,

Haddad³

et al. 2021

RECIS

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Objetivo: o objetivo é analisar os resultados do rastreamento do câncer de pulmão por tomografia computadorizada de baixa dose (LDCT) por meio do Sistema de Relatórios e Dados de Triagem de TC de Pulmão (Lung-RADS) em um centro de câncer brasileiro. Materiais e métodos: revisamos retrospectivamente os prontuários de pacientes submetidos ao programa de rastreamento de câncer de pulmão de LDCT basal no A.C. Camargo Cancer Center. Os critérios de inclusão e exclusão foram iguais aos do National Lung Cancer Screening Trial (NLST). Os critérios para achados de imagem foram aqueles classificados de acordo com as categorias de avaliação do Lung Imaging Reporting and Data System (Lung-RADS). Resultados: Dos 287 indivíduos avaliados neste estudo, 72,1% apresentaram TC de triagem negativa (categorias 1 ou 2 do Lung-RADS), o restante teve TC de triagem positiva, considerando 5,6% na categoria 4A de Lung-RADS, 2,1% na categoria 4B e 1,0% na categoria 4X. Os principais achados foram avaliados em 218 (75,9%) indivíduos, com nódulos sólidos (64,8%), parcialmente sólidos (2,7%) e não sólidos (8,3%). A maioria dos pacientes (59,1%) apresentaram nódulos sólidos menores que 6 mm. Os resultados histológicos confirmaram câncer de pulmão em 2 casos (prevalência de 0,7% de todos os pacientes triados). Conclusões: A prevalência de câncer de pulmão em nossa amostra foi compatível com a literatura. No entanto, tivemos uma prevalência maior das categorias 3 e 4A do Lung-RADS do que o esperado. Isso pode estar associado à maior incidência de doenças granulomatosas, principalmente tuberculose, na população brasileira.

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Low-dose CT screening for lung cancer in Brazil: a study protocol

Cited by 6 publications

References 7 publications

Challenges in Lung Cancer Screening in Latin America

Challenges in Lung Cancer Screening in Latin America

Mobile Lung Cancer Screening in Limited Resource Regions: The ProPulmão Project (BRELT3) Study Protocol

Lung-RADS usado no rastreamento do câncer de pulmão: a doença granulomatosa faz diferença?

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