2011
DOI: 10.1590/s1806-37132011000500017
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Doença do refluxo gastroesofágico e hiperresponsividade das vias aéreas: coexistência além da chance?

Abstract: Gastroesophageal reflux disease and asthma are both quite common the world over, and they can coexist. However, the nature of the relationship between these two diseases remains unclear. In this study, we review controversial aspects of the relationships among asthma, airway hyperresponsiveness, and gastroesophageal reflux disease in adults and in children.

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Cited by 9 publications
(6 citation statements)
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References 53 publications
(78 reference statements)
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“…The presence of gastroesophageal reflux is correlated with increased inflammation in the airways of patients with bronchiectasis and is associated with increased asthma severity. However, because of a lack of well-conducted longitudinal studies, the relationship between gastroesophageal reflux disease and bronchial hyperresponsiveness may not be causal and may not be associated with severity (46). In addition, a low birth weight may predispose individuals to the development of asthma (47) or COPD (48).…”
Section: Introductionmentioning
confidence: 99%
“…The presence of gastroesophageal reflux is correlated with increased inflammation in the airways of patients with bronchiectasis and is associated with increased asthma severity. However, because of a lack of well-conducted longitudinal studies, the relationship between gastroesophageal reflux disease and bronchial hyperresponsiveness may not be causal and may not be associated with severity (46). In addition, a low birth weight may predispose individuals to the development of asthma (47) or COPD (48).…”
Section: Introductionmentioning
confidence: 99%
“…Hypotheses regarding how GERD can affect asthma include microaspiration (acid reflux having direct effects on the tracheobronchial mucosa) and vagal stimulation caused by the presence of acid in the esophagus. (14) A common comorbidity in patients with COPD, GERD appears to be associated with an increased risk of exacerbations. Although GERD treatment is not associated with a clear improvement in asthma control, the presence of symptoms in our patient led us to prescribe proton pump inhibitors, with good results.…”
Section: Overlap Between Asthma and Copdmentioning
confidence: 99%
“…It reaches 7-8% of children and is present in about 50% of children in the first four months of life. (1) The reflux is characterized as physiological when presented in the first months of life. The postprandial regurgitation arises between birth and the first six months of life, often with spontaneous resolution until the first year of the child.…”
Section: Introductionmentioning
confidence: 99%