Osteíte por BCG

Yamada, André Fukunishi; Pellegrini, Juliana Barbosa; Cunha, Luciana Menezes; Fernandes, Artur da Rocha Corrêa

doi:10.1590/s1806-37132009000300015

Cited by 6 publications

(9 citation statements)

References 13 publications

(28 reference statements)

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“…(3) Letter to the Editor Osteitis in a female infant after vaccination with BCG Moreau in the neonatal period immunocompetent child who presented with radial and ulnar lesions and who was highly suspected of having BCG osteitis, although the bacillus was not identified. (8) The diagnosis of BCG osteitis in our patient is indisputable. Tuberculin skin testing confirmed that PPD positivity does not depend on M. tuberculosis, given that ELISPOT assay results were negative.…”

Section: To the Editormentioning

confidence: 69%

“…However, it should be noted that BCG Moreau is not as widely used as are other strains, particularly BCG Glaxo and BCG Pasteur-Paris. In Brazil, one group of authors (8) recently reported the case of a normal-weight, (5,10) Involvement of other bones, such as the sternum (11) and the sacrum, (12) is extremely rare. The unilaterality of the disease suggests that circulation was increased (by minimal trauma, for instance) prior to the onset of the bacilli.…”

Section: To the Editormentioning

confidence: 99%

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Osteíte por BCG Moreau em uma menina vacinada ao nascer

et al. 2012

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Section: To the Editormentioning

confidence: 69%

Section: To the Editormentioning

confidence: 99%

Osteíte por BCG Moreau em uma menina vacinada ao nascer

et al. 2012

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“…The diagnosis of osteitis after BCG vaccination in our case was established according to the criteria proposed by Foucard and Hjelmstedt in 1971 which include BCG vaccination in the neonatal period, period of less than 4 years between vaccination and symptom onset, no contact between the child and any adults with tuberculosis, a consistent clinical profile, and histopathology suggestive of tuberculosis [ 13 ]. Our case developed a bony lesion in the distal radius which is very rare.…”

Section: Discussionmentioning

confidence: 99%

Osteitis of the radius following Bacillus Calmette–Guérin vaccination at birth: a case report

Kheir

Ibrahim

et al. 2017

J Med Case Reports

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BackgroundThe Bacillus Calmette–Guérin vaccine, which is used for the prevention of tuberculosis, is considered protective against the severe forms of childhood tuberculosis. However, some serious adverse reactions including osteitis of the long bones can occur.Case presentationWe report a case of an 18-month-old Sudanese girl who presented at the age of 3 months with swelling of her left forearm following Bacillus Calmette–Guérin vaccination administered at birth. Radiological and histological investigations confirmed tuberculous osteitis of the distal radius. She responded very well to antituberculous treatment with complete healing at follow-up visits. To the best of our knowledge this is the first case report of osteitis of the radius following Bacillus Calmette–Guérin vaccination described from Sudan.ConclusionsBacillus Calmette–Guérin osteitis, although rare, should be considered a possible complication of the Bacillus Calmette–Guérin vaccination, and early diagnosis and treatment are essential.

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“…[1] Despite being considered as a safe vaccine, it has been associated with complications both at local and systemic levels. [2] These complications include ulceration on the site of application, circular adenopathies, osteitis, and dissemination of the disease, which usually occurs in immunocompromised patients. [3] The appearance of the adverse effects depends on multiple factors such as dose, strain, method of application and the immunological status of the vaccinated individual.…”

Section: Introductionmentioning

confidence: 99%

“…The lack of response to antimicrobial management, atypical biochemistry, as well as the clinical presentation in a patient suggests the presence of this entity. [2] There are criteria proposed by Foucard & Hjelmsted in 1971 to facilitate the diagnosis of the cases of osteitis associated with the BCG vaccine. [6]…”

Section: Introductionmentioning

confidence: 99%

Osteitis secondary to BCG vaccine in immunocompetent patients

Saldaña¹,

Ranero²,

Trujillo

et al. 2019

Medicine

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Rationale:Osteitis corresponds to a rare but potentially serious complication reported in pediatric population after the application of the Bacillus Calmette-Guerin (BCG) vaccine. In the present study, 3 clinical cases associated with this entity are reported.Patient concerns:The 1st case corresponds to a 1-year-old female patient who presented an increase in the volume of the right pelvic limb after BCG application. The second case is a 2-year-old male who began with an increase in volume, overactive gait and pain at the level of the left knee on walking that began after a trauma in the left low limb. The 3rd case corresponds to a 3-year-old patient who started with intense pain and limitation for ambulation.Diagnosis:Both the radiographical and histological studies presented data suggestive of infection by Mycobacterium tuberculosis complex, corroborated through biopsy and genotyping analysis with the isolation of Mycobacterium bovis as the causal agent.Interventions:The basic treatment scheme was based on Ethambutol, Rifampicin, Pyrazinamide, and Isoniazid. When M. bovis was typified, clarithromycin was added in the treatment.Outcomes:Osteitis secondary to BCG vaccine usually has a favorable evolution, especially in immunocompetent patients.Lessons:It was possible to confirm the association of BCG vaccine with the clinical picture of the patients who presented improvement after the start of antimicrobial management. Osteitis secondary to BCG vaccine usually presents a favorable evolution, especially in immunocompetent patients; however, the involvement of joint, growth discs and vertebrae increases the risk of presenting long-term sequels.

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Osteíte por BCG

Cited by 6 publications

References 13 publications

Osteíte por BCG Moreau em uma menina vacinada ao nascer

Osteíte por BCG Moreau em uma menina vacinada ao nascer

Osteitis of the radius following Bacillus Calmette–Guérin vaccination at birth: a case report

Osteitis secondary to BCG vaccine in immunocompetent patients

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