Desenvolvimento de uma órtese de Dumon modificada para aplicações traqueais: um estudo experimental em cães

Xavier, Rogério Gastal; Sanches, Paulo Roberto Stefani; Neto, Amarílio Vieira de Macedo; Kuhl, Gabriel; Vearick, Samanta Bianchi; Michelon, Marcelo Dall'Onder

doi:10.1590/s1806-37132008000100005

Cited by 13 publications

(6 citation statements)

References 14 publications

(22 reference statements)

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“…Bradypus variegatus apresentou cartilagens com a forma de "C" somente na porção cervical e parte da torácica, no qual, as extremidades desses semi-anéis eram ligadas por um delicado feixe de mús-culo liso (Fig. 1C), assemelhando-se ao modelo canino e dos humanos, como descreveu Xavier et al (2008), bem como Saimiri sciureus (Pinheiro et al 2012), Lemuroidea (Straus 1931) e Siphonops annulatus (Kuehne & Junqueira 2000). Ao contrário de gansos em que a traqueia apresentou anéis completos (Santos et al 2008).…”

Section: Discussionunclassified

Morfologia e morfometria da traqueia da preguiça (Bradypus variegatus): conhecimentos para procedimentos de emergência

et al. 2015

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As the sloth (Bradypus variegatus) is a little studied species, especially from a morphological point of view, this research aimed to define the anatomy of its trachea. The information would facilitate the selection of a proper endotracheal tube, laryngeal mask or tracheostomy tube for anesthesia and emergency procedures, since it appeared to have a special morphology. Eleven young animals of different ages were investigated, four males and seven females, obtained from the Emilio Goeldi Museum and donated to UFRA. The specimens were infused intramuscularly with 10% aqueous formaldehyde for preservation and were later dissected at the cervico-thoracic level, by mesoscopia, exposing the area from the larynx to the right and left primary bronchi at the hilum. The tracheae were divided into five regions (cervical, first flexure, second flexure, third flexure, and carina) for which length and width were measured, as well as the total tracheal length. Sharp windings were seen in the middle caudal portion, including the carina. The average tracheal length was 14.6 cm. Microscopically, the trachea was made up of separate plates of hyaline cartilage forming each ring, lined with ciliated epithelium. Despite the trachea of the common sloth displaying the same lining pattern found in other animals, there are no reports in the literature of other species having a macroscopic morphology as described here, which leads us to suggest, where appropriate access to emergency ventilation, the practice of IOT and not tracheostomy.

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Section: Discussionunclassified

Morfologia e morfometria da traqueia da preguiça (Bradypus variegatus): conhecimentos para procedimentos de emergência

et al. 2015

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“…Besides other techniques, stent-related technologies continue to evolve to overcome the current shortcomings of stents (migration, mucostasis, and granulation tissue formation). Recently developed stents or currently developing stents include drug-eluting stents, stents with a new design, stent with a hydrophilic coating of the inner surface, radiopaque silicone stents, bioabsorbable stents, and 3D-engineered/printed stents (3)(4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

Rapid Establishment of Tracheal Stenosis in Pigs Using Endotracheal Tube Cuff Overpressure and Electrocautery

et al. 2021

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Background: Central airway obstruction can be caused by cancer, tracheal intubation, or tuberculosis, among others. If surgery is contraindicated, bronchoscopic therapy may be performed. Bronchoscopic treatment for airway obstruction is continuously evolving. In particular, attempts to overcome the current shortcomings of airway stents (stent migration, mucostasis, and granulation tissue formation) are currently ongoing. To apply a new airway stent to humans, preclinical studies in an appropriate animal model is needed. Canine and porcine tracheas have been used as animal airway stenosis models. However, existing models take a long time to develop (3-8 weeks) and have a disadvantage that the mechanism of stenosis is different from that in humans.Purpose: To establish a new and fast tracheal stenosis model in pigs using a combination of cuff overpressure intubation and electrocautery.Methods: Fourteen pigs were divided into three groups: tracheal cautery (TC) group (n = 3), cuff overpressure intubation (COI) group (n = 3), and COI-TC combination group (n = 8). Cuff overpressure (200/400/500 mmHg) was applied using a 9-mm internal diameter endotracheal tube. Tracheal cautery (40/60 watts) was performed using a rigid bronchoscopic electrocoagulator. After intervention, the pigs were observed for 3 weeks and bronchoscopy was performed every 7 days. When the cross-sectional area decreased by > 50%, it was judged that tracheal stenosis was established. Results:The time for tracheal stenosis was 14 days in the TC group and 7 days in the COI-TC combination group. In the COI group, no stenosis occurred. In the COI-TC group, electrocautery (40 watts) immediately after intubation for > 1 hour with a cuff pressure of 200 mmHg or more resulted in sufficient tracheal stenosis within 7 days. Moreover, the degree of tracheal stenosis .

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“…These devices are largely applied in blood vases, urethra, trachea, bronchi, besides other systems [4,[11][12][13] . For application in respiratory system, the stent is considered a convenient treatment for patients with benign stenosis, chronicle obstructive pulmonary disease, heart diseases, diabetes, and other systemic disorders, offering immediate respiratory symptoms relief, with an improve in forced expiratory volume and, consequently, improving patient quality of life [13][14][15][16] . The PLGA/IR blend can be classified as a solution blend, since the polymers are dissolved in a common solvent and the solvent is removed [7] .…”

Section: Introductionmentioning

confidence: 99%

Analysis of Poly(Lactic-co-Glycolic Acid)/Poly(Isoprene) Polymeric Blend for Application as Biomaterial

Marques¹,

Santos²,

Schopf³

et al. 2013

Polímeros

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Abstract:The application of renewable raw materials encourages research in the biopolymers area. The Poly(Lacticco-Glycolic Acid)/Poly(Isoprene) (PLGA/IR) blend combines biocompatibility for application in the health field with excellent mechanical properties. The blend was obtained by solubilization of polymers in organic solvents. To investigate the polymer thermochemical properties, FTIR and DSC were applied. To investigate the composition's influence over polymer mechanical properties, tensile and hardness test were applied. To analyze the blends response in the cell environment, a stent was produced by injection molding process, and Cell Viability Test and Previous Implantability were used. The Infrared spectra show that chemical composition is related only with polymers proportion in the blend. The calorimetry shows a partial miscibility in the blend. The tensile test shows that adding Poly(Isoprene) to Poly(Lactic-co-Glycolic Acid) induced a relevant reduction in the Young modulus, tensile stress and tenacity of the material, which was altered from the fragile raw PLGA to a ductile material. The composition did not affect the blend hardness. The cell viability test shows that the blend has potential application as biomaterial, while the first results of implantability indicate that the polymeric stent kept its original position and caused low fibrosis.

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Desenvolvimento de uma órtese de Dumon modificada para aplicações traqueais: um estudo experimental em cães

Abstract: The stent developed proved resistant to mechanical stress, biocompatible in the canine trachea and well-preserved at the study endpoint.

Cited by 13 publications

References 14 publications

Morfologia e morfometria da traqueia da preguiça (Bradypus variegatus): conhecimentos para procedimentos de emergência

Morfologia e morfometria da traqueia da preguiça (Bradypus variegatus): conhecimentos para procedimentos de emergência

Rapid Establishment of Tracheal Stenosis in Pigs Using Endotracheal Tube Cuff Overpressure and Electrocautery

Analysis of Poly(Lactic-co-Glycolic Acid)/Poly(Isoprene) Polymeric Blend for Application as Biomaterial

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