Fatores de risco para a recidiva da tuberculose

Picon, Pedro Dornelles; Bassanesi, Sérgio Luiz; Caramori, M. Luiza; Ferreira, Roberto Luiz Targa; Jarczewski, Carla Adriane; Vieira, Patricia Rodrigues de Borba

doi:10.1590/s1806-37132007000500013

Cited by 39 publications

(36 citation statements)

References 24 publications

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“…Relapses were higher than the 4.3% found by Picon et al 17 in Rio Grande do Sul and lower than the 7.8% recorded by Yamagishi and Toyota 18 in Japan. Likewise, readmissions were lower than the 9.9% registered by Barbosa and Costa 19 in the city of Natal, but higher than the 3.6% described by Furlan et al 20 in the state of Paraná.…”

Section: Discussioncontrasting

confidence: 55%

“…Relapses were associated in adults older than 40 years, similar to the findings of Oliveira and Moreira Filho 6 , but different from the findings of Picon et al 17 , who did not find association with age. This association of relapse with age can be explained as resulting from decreased immunity, concomitant diseases and malnutrition.…”

Section: Discussioncontrasting

confidence: 46%

“…Alcohol abuse has been associated with readmission to treatment, which in addition to affecting the immune system contributes significantly to treatment abandonment and has been shown to be a predictor of irregular chemotherapy 17 , which explains the higher percentage of alcohol abuse among the readmitted patients 25,26,[31][32][33] . While AIDS, after adjustment, has not shown an association with cases of retreatment due to relapse of this study, it is important to highlight that literature has strongly evidenced this relationship 9,17,34 , which can be explained by immunodeficiency, which facilitates exogenous reinfection and endogenous activation 2,9,35,36 , in addition to treatment plans for both AIDS and TB having adverse side effects, which contributes to abandonment and consequent readmission 37 . Readmission cases were almost six times more likely to result in new treatment abandonment, in agreement with findings by Dooley et al…”

mentioning

confidence: 99%

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Fatores associados ao retratamento da tuberculose nos municípios prioritários do Maranhão, Brasil

Silva

Matsuoka

Aquino

et al. 2017

Ciênc. saúde coletiva

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Section: Discussioncontrasting

confidence: 55%

Section: Discussioncontrasting

confidence: 46%

mentioning

confidence: 99%

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Fatores associados ao retratamento da tuberculose nos municípios prioritários do Maranhão, Brasil

Silva

Matsuoka

Aquino

et al. 2017

Ciênc. saúde coletiva

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“…(7,11) Noncompliance with treatment for pulmonary tuberculosis in smear-positive patients favors the persistence of the transmission chain, as well as the increase in bacterial populations that are resistant to first-line chemotherapy. (12,13) This situation is a cause for concern, because it requires strategic measures to motivate patients to be more compliant with the treatment regimen.…”

mentioning

confidence: 99%

Fatores preditores para o abandono do tratamento da tuberculose pulmonar preconizado pelo Ministério da Saúde do Brasil na cidade de Porto Alegre (RS)

2011

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Objective: To determine the predictors of noncompliance with the pulmonary tuberculosis treatment regimen recommended by the Brazilian National Ministry of Health, in previously treatment-naïve patients with active tuberculosis treated in the city of Porto Alegre, Brazil. Methods: This was a case-control study involving six referral primary health care clinics for tuberculosis in Porto Alegre. We reviewed the medical charts of all previously treatment-naïve patients with active pulmonary tuberculosis who were noncompliant with the treatment between 2004 and 2006. Those were paired with other patients having similar characteristics and having been cured. We conducted univariate and multivariate analyses. Results: Of the 2,098 patients included, 218 (10.4%) became noncompliant with the treatment. In the multivariate analysis, the factors most strongly associated with treatment noncompliance were being an alcoholic (with or without concomitant use of illicit drugs), being HIV-infected, not residing with family members, and having a low level of education. In the univariate analysis, treatment noncompliance was also significantly associated with being younger and with being non-White. Gender was not significantly associated with treatment noncompliance; nor was the occurrence of adverse effects of the drugs included in the regimen. Conclusions: In the population studied, being an alcoholic, being HIV-infected, and not residing with family members were the major predictors of noncompliance with treatment for pulmonary tuberculosis among previously treatment-naïve patients. ResumoObjetivo: Determinar os fatores preditores de abandono do tratamento da tuberculose pulmonar, preconizado pelo Ministério da Saúde do Brasil, em pacientes bacilíferos virgens de tratamento atendidos na cidade de Porto Alegre (RS). Métodos: Estudo de caso-controle envolvendo seis unidades básicas de saúde de referência para o tratamento da tuberculose em Porto Alegre, com a revisão dos prontuários de todos os casos de abandono do tratamento por parte de pacientes com tuberculose pulmonar bacilíferos e virgens de tratamento entre 2004 e 2006. Os pacientes incluídos no estudo foram pareados com pacientes com características semelhantes e cujo desfecho foi de cura. Foram realizadas análises univariada e multivariada. Resultados: Dos 2.098 pacientes incluídos no estudo, 218 (10,4%) abandonaram o tratamento. De acordo com a modelo da análise multivariada utilizado, as associações mais significantes para o abandono do tratamento foram o etilismo (com ou sem a concomitância de uso de drogas ilícitas), a infecção por HIV, o fato de o paciente não residir com familiares e o baixo nível de escolaridade. Na análise univariada, indivíduos mais jovens e de etnia não branca também se revelaram significativos para o abandono do tratamento. Gênero e ocorrência de efeitos adversos da medicação não mostraram associação com o abandono. Conclusões: Na população estudada, alcoolismo, infecção por HIV e o fato de o paciente não residir com familiares foram...

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“…Em um estudo que buscou identificar os fatores de risco para a recidiva da Tb, o uso irregular de medicamentos e a infecção pelo HIV mostraram-se relacionados com taxas maiores deste tipo de caso 14 . O predomínio do caso novo corrobora os achados da literatura.…”

Section: Introdução Métodounclassified

A ocorrência da tuberculose em um distrito administrativo do Município de São Paulo

Hino¹,

Takahashi²,

Bertolozzi³

et al. 2013

Esc. Anna Nery

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Fatores de risco para a recidiva da tuberculose

Cited by 39 publications

References 24 publications

Fatores associados ao retratamento da tuberculose nos municípios prioritários do Maranhão, Brasil

Fatores associados ao retratamento da tuberculose nos municípios prioritários do Maranhão, Brasil

Fatores preditores para o abandono do tratamento da tuberculose pulmonar preconizado pelo Ministério da Saúde do Brasil na cidade de Porto Alegre (RS)

A ocorrência da tuberculose em um distrito administrativo do Município de São Paulo

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