Os radicais livres de oxigênio e as doenças pulmonares

Júnior, Dahir Ramos de Andrade; Souza, Rodrigo Becco de; Santos, Sânia Alves dos; Andrade, Dahir Ramos de

doi:10.1590/s1806-37132005000100011

Cited by 42 publications

(15 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Moreover, in the lung tissue a peculiarity occurs: oxygen reaches the alveoli by two routes, perfusion and ventilation. This alveolar oxygen helps maintain aerobic metabolism and delays the occurrence of hypoxia 12 . This mechanism would tend to protect lung tissue from oxidative stress and delay the onset of damage, resulting in less need to produce antioxidant proteins compared to other tissue such as the intestine.…”

Section: ■ Discussionmentioning

confidence: 99%

Effect of hyperbaric oxygenation on the expression of glutathione peroxidase 4 and lactoperoxidase genes in the lung of isogenic mice after ischemia/reperfusion injury in the small bowel

Ikejiri

Neto²,

Bertoletto³

et al. 2018

Acta Cir. Bras.

View full text Add to dashboard Cite

show abstract

Section: ■ Discussionmentioning

confidence: 99%

Effect of hyperbaric oxygenation on the expression of glutathione peroxidase 4 and lactoperoxidase genes in the lung of isogenic mice after ischemia/reperfusion injury in the small bowel

Ikejiri

Neto²,

Bertoletto³

et al. 2018

Acta Cir. Bras.

View full text Add to dashboard Cite

show abstract

“…The fact that catalase did not suffer any change between the groups studied may have occurred probably because this enzyme is only activated or released when there is an excess in the concentration of H 2 O 2 , as in small quantities to glutathione peroxidase, which plays the role of transforming the peroxide hydrogen in water. This means that, in most cases, the presence of catalase is important to protect the organism, in cases of acute oxidative stress (Urbina et al 2004;Andrade Júnior et al 2005).…”

Section: Discussionmentioning

confidence: 99%

Levels of oxidative stress markers: correlation with hepatic function and worm burden patients with schistosomiasis

Cunha

Silva

Bessa

et al. 2012

Acta Parasitologica

View full text Add to dashboard Cite

Schistosomiasis is caused by Schistosoma mansoni and is a public health problem in Brazil. The typical granulomatous lesion is associated with the increase in the oxidative damage by generation of free radicals. The aim of this work was to correlate some oxidative stress markers with the worm burden on carriers of schistosomiasis (n = 30) in the acute phase in comparison to healthy subjects (n = 30). The pro-oxidant parameter used was the colorimetric quantification of reactive substances to thiobarbituric acid, while the antioxidant markers used were blood content of reduced glutathione and determination of the activity of catalase. The worm burden was assessed by Kato-Katz method. The results pointed out that initially there was no difference in the catalase activity. However, there was a positive correlation between the increase in parasitic load and intensity of lipid peroxidation, and decrease in the content of reduced glutathione. Additionally, only the aspartate aminotransferase levels presented to be high, while there was a decrease in bilirubin level. Therefore, a possible association between the establishment of the oxidative stress in tissue and the parasitic load of Schistosoma mansoni is suggested.

show abstract

“…Andrade Júnior (2005) and Del Rio et al (2005) inferred that MDA is highly cytotoxic and genotoxic, and should be considered more than just a biomarker of oxidative damage, owing to its interaction with DNA and other proteins. High levels of MDA are routinely used as a way to detect oxidative stress in several human diseases, such as systemic lupus erythematosus, diabetes, pulmonary diseases, Alzheimer's disease, and cancer, which allow us to have funding for the research in animals (FERREIRA; MATSUBARA, 1997;ANDRADE JÚNIOR, 2005;PÉREZ et al, 2012). The most widely used technique for measuring MDA is the thiobarbituric acid reactive substances (TBARS) assay.…”

Section: Biomarkers Of Oxidative Stressmentioning

confidence: 99%

Oxidative stress in dogs

Russo

Bracarense

2016

SCA

View full text Add to dashboard Cite

Reactive oxygen species (ROS), also known as free radicals, are generated during cellular respiration. Under normal conditions, the body has the ability to neutralize the effects of free radicals by using its antioxidant defenses. In the case of an imbalance between oxidants and antioxidants, free radical production exceeds the capacity of organic combustion, resulting in oxidative stress. Of all the cellular components compromised by the harmful effects of ROS, the cell membrane is the most severely affected owing to lipid peroxidation, which invariably leads to changes in the membrane structure and permeability. With lipid peroxidation of the cell membrane, some by-products can be detected and measured in tissues, blood, and other bodily fluids. The measurement of biomarkers of oxidative stress is commonly used to quantify lipid peroxidation of the cell membrane in humans, a species in which ROS can be considered as a cause or consequence of oxidative stress-related diseases. In dogs, few studies have demonstrated this correlation. The present review aims to identify current literature knowledge relating to oxidative stress diseases and their detection in dogs. Key words: Oxidative stress. Lipid peroxidation. Free radicals. Dogs. ResumoNos processos decorrentes da respiração celular, são gerados produtos denominados espécimes reativos de oxigênio (EROS), conhecidos também como radicais livres. Em condições normais, o organismo possui capacidade de neutralizar os efeitos dos radicais livres utilizando suas defesas antioxidantes. Em situações de desequilíbrio entre agentes oxidantes e antioxidantes, a produção de radicais livres excede a capacidade orgânica de neutralização, resultando na condição conhecida como estresse oxidativo. Dentre todos os componentes celulares atingidos pelos efeitos nocivos dos EROS, as membranas celulares são as estruturas mais severamente acometidas, devido à peroxidação lipídica, que leva, invariavelmente, a alterações estruturais e também na sua permeabilidade. Na peroxidação lipídica da membrana celular, alguns subprodutos podem ser detectados e mensurados nos tecidos, sangue e outros fluidos corpóreos. A mensuração de biomarcadores de estresse oxidativo é habitualmente utilizada para quantificar a lipoperoxidação da membrana celular em humanos, espécie onde as EROS podem ser consideradas como causa ou consequência de doenças relacionadas ao estresse oxidativo. Nos cães, alguns poucos estudos demonstram essa correlação. A presente revisão tem como principal objetivo verificar na literatura, onde se encontra atualmente o conhecimento relacionando o estresse oxidativo às doenças em cães bem como as possíveis formas de detecção de biomarcadores na espécie canina. Palavras-chave: Estresse oxidativo. Lipoperoxidação. Radicais livres. Cães.

show abstract

Os radicais livres de oxigênio e as doenças pulmonares

Cited by 42 publications

References 46 publications

Effect of hyperbaric oxygenation on the expression of glutathione peroxidase 4 and lactoperoxidase genes in the lung of isogenic mice after ischemia/reperfusion injury in the small bowel

Effect of hyperbaric oxygenation on the expression of glutathione peroxidase 4 and lactoperoxidase genes in the lung of isogenic mice after ischemia/reperfusion injury in the small bowel

Levels of oxidative stress markers: correlation with hepatic function and worm burden patients with schistosomiasis

Oxidative stress in dogs

Contact Info

Product

Resources

About