Antinociceptive and anti-inflammatory effect of Agaricus blazei Murill in rats submitted to the modified formalin test

Abstract

Sociedade Brasileira para o Estudo da Dor c Rev Dor. São Paulo, 2011 jan-mar;12(1):35-8 SUMMARY BACKGROUND AND OBJECTIVES:The consumption of mushrooms in popular and traditional medicine is associated to immune modulating activity. It is known that decreasing the inflammatory process will decrease nociception. This study aimed at checking the antinociceptive and anti-inflammatory activity of Agaricus blazei Murill, mushroom of the sun, in Wistar rats using the modified formalin test. METHOD: Animals (n = 18) were distributed in the following groups: Control Group (CG): non-treated animals receiving just 2% Tween solvent (n = 6); Treated Group (TG): animals daily treated orally with 2.65 mg of A. blazei powder in 2% Tween solvent for 15 days (n = 12). After treatment, they were submitted to the modified formalin test. RESULTS: After formalin injection, the three phases of the formalin test were observed in CG and TG animals. The treatment with A. blazei has not interfered with formalin test phases I or II, but has decreased the number of paw elevations in phase III. CONCLUSION: The treatment with Agaricus blazei during 15 days had action in nociceptive response and acute inflammation because rats treated with Agaricus had a lower number of paw movements during phase III,

Anti-inflammatory potential of Agaricus in carrageenan-induced model of local inflammation in rats

“…The first hypothesis could be supported by data reported by 19 who reported that treatment of rats with A. blazei during 15 days had an inhibitory action on nociceptive response and acute inflammation induced by formalin injection. The inhibitory protective effect was indicated by that rats treated with Agaricus had a lower number of paw movements during the late phase which is related to the induced mediators of the acute inflammatory process including NO and prostaglandins.…”

Activity of mushrooms against diabetic and inflammation: A review

“…Agaricus blazei whole mushroom chloroform extract and Agaricus bisporus whole mushroom methanol extract reported to have antiinflammatory property [76,77]. Agaricus blazei powder in the form of capsules showed anti-inflammatory effect on Paw edema in rats [78]. Anti-inflammatory activity of ethanol and methanol extracts of Elaphomyces granulatus and Caripia montagnei were documented [79,80].…”