Interictal abnormal fMRI activation of visual areas during a motor task cued by visual stimuli in migraine

Conforto, Adriana Bastos; Chaim, Khallil Taverna; Peres, Mário Fernando Prieto; Gonçalves, André Leite; Siqueira, Inara Laurindo; Barreiros, Maria Angela M.; Amaro, Edson

doi:10.1590/s1679-45082017ao3719

Cited by 4 publications

(4 citation statements)

References 27 publications

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“…These areas are the major regions of the visual network identified in previous resting-state positron emission tomography (PET) [24] and fMRI [25] studies. ICA values decreased in the right lingual gyrus as well as in the left calcarine sulcus, which are mainly involved in processing and modulation of pain [26, 27]. A resting-state fMRI study [28] showed that similarly decreased regional homogeneity of the lingual gyrus in MwoA with long-term and short-term disease duration, compared with HC, and showed that a long history of MwoA might contribute to accumulating brain dysfunction due to repetitive attacks.…”

Section: Discussionmentioning

confidence: 99%

Impaired intrinsic functional connectivity between the thalamus and visual cortex in migraine without aura

et al. 2019

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Background: Resting-state functional magnetic resonance imaging (fMRI) has confirmed disrupted visual network connectivity in migraine without aura (MwoA). The thalamus plays a pivotal role in a number of pain conditions, including migraine. However, the significance of altered thalamo-visual functional connectivity (FC) in migraine remains unknown. The goal of this study was to explore thalamo-visual FC integrity in patients with MwoA and investigate its clinical significance. Methods: Resting-state fMRI data were acquired from 33 patients with MwoA and 22 well-matched healthy controls. After identifying the visual network by independent component analysis, we compared neural activation in the visual network and thalamo-visual FC and assessed whether these changes were linked to clinical characteristics. We used voxel-based morphometry to determine whether functional differences were dependent on structural differences. Results: The visual network exhibited significant differences in regions (bilateral cunei, right lingual gyrus and left calcarine sulcus) by inter-group comparison. The patients with MwoA showed significantly increased FC between the left thalami and bilateral cunei and between the right thalamus and the contralateral calcarine sulcus and right cuneus. Furthermore, the neural activation of the left calcarine sulcus was positively correlated with visual analogue scale scores (r = 0.319, p = 0.043), and enhanced FC between the left thalamus and right cuneus in migraine patients was negatively correlated with Generalized Anxiety Disorder scores (r = − 0.617, p = 0.005). Conclusion: Our data suggest that migraine distress is exacerbated by aberrant feedback projections to the visual network, playing a crucial role in migraine physiological mechanisms. The current study provides further insights into the complex scenario of migraine mechanisms.

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Section: Discussionmentioning

confidence: 99%

Impaired intrinsic functional connectivity between the thalamus and visual cortex in migraine without aura

et al. 2019

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“…Cortical activation induced by external stimuli has drawn attention in past years [10–12]. The study of connectivity in regard to synchronization and information processing has revealed differences under visual stimulation between migraineurs and controls [13, 14]; this result suggested that these methods would be useful for outlining stimulus processing in migraine and providing further information on how the internal regions change their connections under the influence of external inputs.…”

Section: Introductionmentioning

confidence: 99%

Abnormal functional connectivity under somatosensory stimulation in migraine: a multi-frequency magnetoencephalography study

et al. 2019

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BackgroundAlthough altered neural networks have been demonstrated in recent MEG (magnetoencephalography) research in migraine patients during resting state, it is unknown whether this alteration can be detected in task-related networks. The present study aimed to investigate the abnormalities of the frequency-specific somatosensory-related network in migraine patients by using MEG.MethodsTwenty-two migraineurs in the interictal phase and twenty-two sex- and age-matched healthy volunteers were studied using a whole-head magnetoencephalography (MEG) system. Electrical stimuli were delivered alternately to the median nerve on the right wrists of all subjects. MEG data were analyzed in a frequency range of 1–1000 Hz in multiple bands.ResultsThe brain network patterns revealed that the patients with migraine exhibited remarkably increased functional connectivity in the high-frequency (250–1000 Hz) band between the sensory cortex and the frontal lobe. The results of quantitative analysis of graph theory showed that the patients had (1) an increased degree of connectivity in the theta (4–8 Hz), beta (13–30 Hz) and gamma (30–80 Hz) bands; (2) an increased connectivity strength in the beta (13–30 Hz) and gamma (30–80 Hz) bands; (3) an increased path length in the beta (13–30 Hz), gamma (30–80 Hz) and ripple (80–250 Hz) bands; and (4) an increased clustering coefficient in the theta (4–8 Hz), beta (13–30 Hz) and gamma (30–80 Hz) bands.ConclusionsThe results indicate that migraine is associated with aberrant connections from the somatosensory cortex to the frontal lobe. The frequency-specific increases in connectivity in terms of strength, path length and clustering coefficients support the notion that migraineurs have elevated cortical networks. This alteration in functional connectivity may be involved in somatosensory processing in migraine patients and may contribute to understanding migraine pathophysiology and to providing convincing evidence for a spatially targeted migraine therapy.

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“…Higher order systems are also affected: a study found reduced FC between the executive and dorsal attention networks that correlated with headache attack frequency in migraine without aura patients [83], which falls in line with studies showing cognitive disturbances during the ictal phase [84]. These baseline, resting state changes carry over to task performance as well [85,86] and are consistent with earlier reports of altered cortical excitability in migraineurs both during the aura phase [87] and in the interictal term [88].…”

Section: Functional Alterationssupporting

confidence: 87%

New directions for structural and functional neuroimaging markers in migraine

Veréb¹

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Migraine is a common primary headache disorder, yet the exact cause and processes underlying the disease are not fully clear. Neuroimaging markers have proven useful in tracking the disease course and acquiring information about the pathomechanism. However, questions remain about the background of identified alterations and their connection to other biomarkers. In this work, we aim to place established alterations of white matter microstructure in the context of neurochemical alterations. Furthermore, we set out to identify new potential functional markers for migraine employing temporal features of functional connectivity that potentially complement current approaches. In the first study, we use tract-based spatial statistics to investigate how microstructural alterations of the white matter relate to interictal serum levels of PACAP38, a neuropeptide implicated in migraine pathogenesis, in a cohort of 26 migraine patients. In the second study, we investigate how temporal features of functional connectivity in the salience network differ between healthy controls (n=32), migraine with (n=20) and migraine without aura patients (n=37), using dynamic conditional correlation. We then proceed to describe the effects of connectivity variability on large-scale network interactions using spectral Granger’s causality. Serum levels of PACAP38 correlated with mean, axial and radial diffusivity in Study 1 (p<0.018, p<0.043, p<0.042, respectively). These findings were located mainly in the left optic radiation and the left posterior corpus callosum, reaching into the parietal and temporal white matter tracts. When we included disease duration in the regression model, the spatial pattern of findings relocated to the left thalamus (mean and axial diffusivity: p<0.01). In Study 2, the temporal variance of correlation was higher in the aura group compared to migraine without aura and healthy controls between the right anterior insula and dorsal anterior cingulate cortex (p<0.011 and p<0.026) and also higher in the aura group compared to healthy controls between the left prefrontal cortex and dorsal anterior cingulate cortex (p<0.021). The sum of causality from the salience to the dorsal attention network in the 0.01-0.05 Hz range was lower in migraine with aura compared to migraine without aura and healthy controls (p<0.032 in both cases). In migraine without aura, the variance of right and left prefrontal cortex connectivity and right anterior insula – right prefrontal cortex connectivity diminished with increasing attack frequency (R= -0.516, p<0.003 and R= -0.456, p<0.012). Causal interaction power in the 0.01-0.05 Hz range between the default mode and dorsal attention networks diminished with longer disease duration in the migraine with aura group (R= -0.525, p<0.036). We also found a relationship between right prefrontal cortex – dorsal anterior cingulate cortex connectivity variance and salience-default mode network causality in the migraine with aura group (R= -0.564, p<0.045). We identified a link between microstructural characteristics of the white matter and serum levels of PACAP38 in the interictal term in migraine patients, which connects neuroimaging and neurochemical markers of migraine, further emphasizing the values of both markers. The second study showed that temporal features of connectivity might be an alternative to current functional connectivity markers in migraine and presents evidence that pathophysiological differences between the main subtypes might manifest in altered brain network function that can be used to objectively differentiate between them.

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Interictal abnormal fMRI activation of visual areas during a motor task cued by visual stimuli in migraine

Cited by 4 publications

References 27 publications

Impaired intrinsic functional connectivity between the thalamus and visual cortex in migraine without aura

Impaired intrinsic functional connectivity between the thalamus and visual cortex in migraine without aura

Abnormal functional connectivity under somatosensory stimulation in migraine: a multi-frequency magnetoencephalography study

New directions for structural and functional neuroimaging markers in migraine

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