Delayed postoperative radiation therapy in local control of squamous cell carcinoma of the tongue and floor of the mouth

Amar, Ali; Chedid, Helma Maria; Curioni, Otávio Alberto; Dedivitis, Rogério Aparecido; Rapoport, Abrão; Cernea, Cláudio Roberto; Brandão, Lenine Garcia

doi:10.1590/s1679-45082014ao3006

Cited by 8 publications

(4 citation statements)

References 8 publications

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“…The literature is controversial about the optimal treatment interval times. Although some studies have advocated an interval of less than 6 weeks for better locoregional control, others have reported no significant differences . No differences could be observed in the rate of locoregional recurrence when comparing treatment interval times in our study.…”

Section: Discussioncontrasting

confidence: 69%

Improved outcomes with oral tongue squamous cell carcinoma in Finland

et al. 2017

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Section: Discussioncontrasting

confidence: 69%

Improved outcomes with oral tongue squamous cell carcinoma in Finland

et al. 2017

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“…11 Treatment usually consists of surgery and radiation therapy, but significant rates of local relapse are not infrequent. 12 Several studies addressed investigations of malignant transformations of PMOL. 1 , 13 …”

Section: Introductionmentioning

confidence: 99%

“…11 O tratamento geralmente consiste em cirurgia e radioterapia, mas ainda são observadas importantes taxas de recidivas locais. 12 Ao longo do tempo, vários estudos se desenvolvem para tratar da ocorrência de transformação maligna nas LOPM. 1 , 13 …”

Section: Introductionunclassified

Potentially malignant oral lesions: clinicopathological correlations

Maia

Pinto

Pereira

et al. 2016

Einstein (São Paulo)

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Objective To determine the incidence of potentially malignant oral lesions, and evaluate and correlate their clinical and pathological aspects.Methods The sample consisted of cases clinically diagnosed as oral leukoplakia, oral erythroplakia, erythroleukoplakia, actinic cheilitis, and oral lichen planus treated at a diagnostic center, between May 2012 and July 2013. Statistical tests were conducted adopting a significance level of 5% (p≤0.05).Results Out of 340 patients, 106 (31.2%) had potentially malignant oral lesions; and 61 of these (17.9%) were submitted to biopsy. Actinic cheilitis was the most frequent lesion (37.5%) and the lower lip was the most affected site (49.6%). Among 106 patients in the sample, 48 (45.3%) reported nicotine consumption, 35 (33%) reported alcohol intake and 34 (32.1%) sun exposure while working. When clinical and histopathological diagnoses were compared, oral erythroplakia and atypical ulcer were the lesions that exhibited greater compatibility (100% each).Conclusion In most cases, clinical and histopathological diagnoses were compatible. An association between the occurrence of erythroplakia, leukoplakia and erythroleukoplakia with smoking was observed. Similarly, an association between actinic cheilitis and sun exposure was noted. Erythroleukoplakia presented the highest malignancy grade in this study. Finally, dental surgeons should draw special attention to diagnosis of potentially malignant oral lesions, choose the best management, and control the lesions to avoid their malignant transformation.

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“…It is well established that time elapsed between surgery and RT inversely affects the prognosis [42]. There are, however, papers questioning this concept, but today it is considered the best to start RT 6 weeks following the surgery [43]. This leaves enough time for dental treatment to be completed before the RT.…”

Section: Dentist's Role In Head and Neck Cancer Teammentioning

confidence: 99%

Oral Side Effects of Head and Neck Irradiation

Brailo¹,

Boras²,

Juras³

et al. 2017

Diagnosis and Management of Head and Neck Cancer

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Head and neck irradiation is the standard treatment of advanced oral/oropharyngeal cancer. The treatment has severe side effects such as mucositis, xerostomia, irradiation caries, trismus, and osteoradionecrosis. Side effects can lead to treatment discontinuation, infection, increased drug consumption, and increased duration of hospital admission and can have negative impact on the quality of life and overall survival. Furthermore, some of them (mucositis and xerostomia) affect almost every (>90%) patient. Since nearly two-thirds of oral/oropharyngeal cancers are diagnosed in advanced stage, one might conclude that the great majority of patients will be affected. However, these side effects can be prevented or at least reduced by proper oral/dental care. Therefore, every patient planned for head and neck irradiation should undergo dental evaluation before beginning of the treatment.

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Delayed postoperative radiation therapy in local control of squamous cell carcinoma of the tongue and floor of the mouth

Cited by 8 publications

References 8 publications

Improved outcomes with oral tongue squamous cell carcinoma in Finland

Improved outcomes with oral tongue squamous cell carcinoma in Finland

Potentially malignant oral lesions: clinicopathological correlations

Oral Side Effects of Head and Neck Irradiation

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